Antilipogenic effect of green tea extract in C57BL/6J‐Lepob/ob mice
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Abstract The objective of this study was to determine the effects of green tea extract (GTE) on lipid metabolism in obese animal models. Male C57BL/6J‐ Lepob/ob mice were divided into control and GTE (0.05 g/100 g diet) groups, which were fed a high‐fat (20 g/100 g diet) diet for 12 weeks. Supplementation of GTE significantly reduced ( p < 0.01) perirenal and total white adipose tissue weights compared with the control group. Also, the plasma HDL‐cholesterol level was significantly higher in the GTE group than in the control group, therefore the GTE group showed a higher HDL‐cholesterol/total‐cholesterol ratio (HTR) and lower atherogenic index (AI) level than the control group. A reduction of hepatic triglyceride content and adipose tissue weight in the GTE group was related to the suppression of enzyme activities for fatty acid synthesis (glucose‐6‐phosphate dehydrogenase and malic enzyme) without affecting fatty acid oxidation enzyme ( β ‐oxidation and carnitine palmitoyl transferase) activities in hepatic and adipose tissue. The current results showed that supplementation of green tea extract is beneficial for antiobesity by the suppression of lipogenesis via regulation of related enzyme activities in hepatic and adipose tissue. Copyright © 2008 John Wiley & Sons, Ltd.Keywords:
Green tea extract
Lipogenesis
Malic enzyme
Fatty acid synthesis
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Lipogenesis
Malic enzyme
Phosphoenolpyruvate carboxylase
Fatty acid synthesis
Acetyl-CoA Carboxylase
Coenzyme A
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Hepatic malic enzyme activity and incorporation of glucose-U- 14 C into fatty acids in liver slices was no greater in birds fed fat-free diets than in those fed the same diets supplemented with corn oil. The results suggest that in the chick, in contrast to the rat, dietary fat does not suppress hepatic lipogenesis.
Lipogenesis
Malic enzyme
Corn oil
Fatty acid synthesis
Liver enzyme
Fat accumulation
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Lipogenesis
Malic enzyme
Fatty acid synthesis
Acetyl-CoA Carboxylase
ATP citrate lyase
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Lipogenesis, as measured by the incorporation of glucose-U-14C into fatty acids by adipose tissue slices was determined periodically in 8 pigs from the age of 35 days (9.0 kg) to 180 days (90.0 kg). In the suckling pig, the capacity for fatty acid synthesis was very low, presumably due to the high-fat content of sow milk. Upon ingestion of the high-carbohydrate diet, fatty acid synthesis increased rapidly and reached a peak at 67 days of age. From 67 days of age there was a gradual decrease in the capacity for fatty acid synthesis with advancing age. Changes in the activities of citrate-cleavage enzyme and malic enzyme occurred in parallel with the changes in fatty acid synthesis, supporting the participation of these enzymes in lipogenesis in pig adipose tissue.
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Malic enzyme
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Lipogenesis
Malic enzyme
Fatty acid synthesis
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We have previously shown that in vivo lipogenesis is markedly reduced in liver, carcass, and in 4 different depots of adipose tissue of rats adapted to a high protein, carbohydrate-free (HP) diet. In the present work, we investigate the activity of enzymes involved in lipogenesis in the epididymal adipose tissue (EPI) of rats adapted to an HP diet before and 12 h after a balanced diet was introduced. Rats fed an HP diet for 15 days showed a 60% reduction of EPI fatty acid synthesis in vivo that was accompanied by 45%-55% decreases in the activities of pyruvate dehydrogenase complex, ATP-citrate lyase, acetyl-CoA carboxylase, glucose-6-phosphate dehydrogenase, and malic enzyme. Reversion to a balanced diet for 12 h resulted in a normalization of in vivo EPI lipogenesis, and in a restoration of acetyl-CoA carboxylase activity to levels that did not differ significantly from control values. The activities of ATP-citrate lyase and pyruvate dehydrogenase complex increased to about 75%-86% of control values, but the activities of glucose-6-phosphate dehydrogenase and malic enzyme remained unchanged 12 h after diet reversion. The data indicate that in rats, the adjustment of adipose tissue lipogenic activity is an important component of the metabolic adaptation to different nutritional conditions.
Lipogenesis
ATP citrate lyase
Fatty acid synthesis
Malic enzyme
Acetyl-CoA Carboxylase
Malate dehydrogenase
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Lipogenesis
Malic enzyme
Fatty acid synthesis
ATP citrate lyase
Corn oil
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Lipogenesis
Malic enzyme
Fatty acid synthesis
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Lipogenesis
Malic enzyme
Subcutaneous adipose tissue
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Lipogenesis
Fatty acid synthesis
Malic enzyme
Acetyl-CoA Carboxylase
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