Enhancement of the Expression of Progesterone Receptor on Progesterone‐Treated Lymphocytes After Immunotherapy in Unexplained Recurrent Spontaneous Abortion
Lin ChiuMotoko NishimuraYasuo IshiiMie NiedaMasaki MaeshimaYuji TakedaniYoichi ShibataKenji TadokoroTakeo Juji
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Abstract:
PROBLEM: The immunological mechanism of an effective immunotherapy with paternal lymphocytes for unexplained recurrent spontaneous abortion (RSA) is not yet clear. Previous studies revealed that progesterone plays an important role in maintaining normal pregnancy and lower expression of progesterone receptor (PGR) on lymphocytes was found in RSA. Therefore, it was of interest to investigate whether immunotherapy for RSA would be able to enhance the expression of PGR on lymphocytes of RSA. METHOD: PGR expression on lymphocytes was analyzed with indirect immunofluorescence using flow cytometry. RESULTS: There was no change of PGR expression on PBL of RSA between pre‐ and post‐immunotherapy ( P > 0.05), while in the presence of 10.0 ug/ml progesterone for 24 h, PGR expressed on PBL on post‐immunotherapy was increased significantly as compared with that of pre‐immunotherapy in successful cases ( P < 0.05) and decreased in abortive cases ( P < 0.05). Most PGR was expressed on both CD4 + and CD8 + lymphocyte subsets. In successful cases, CD8 + PGR + subset of post‐immunotherapy was found to be increased significantly ( P < 0.05) in comparison with that of pre‐immunotherapy. CONCLUSION: The data in the present study suggest that immunotherapy for RSA induced a higher expression of PGR on progesterone‐treated lymphocytes, which may be involved in successful pregnancy.Keywords:
Active immunotherapy
Progesterone receptor
An epidemiological study of abortion and abortion-related mortality in New York State (exclusive of New York City) shows a pattern of continued decline in mortality over the last 20 years. There is a discussion of maternal mortality associated with the following abortion-connected circumstances: infected spontaneous abortion, spontaneous abortion incidental to primary cause of death, therapeutic abortion, elective abortion, and illegal abortion. Infection was found to be the most important factor associated with abortion-related mortality. Women over 25 died 5 times more often than the teenage group who underwent abortion. Increased length of gestation increased the risk of death. Death from illegal abortion fell substantially after 1970, the year in which a liberalized abortion law was passed in New York.
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Objective:To investigate the changes of T lymphocytes sub-types in unexplained recurrent spontaneous abortion(URSA) women before and after active immunotherapy.Methods:Flow cytometry was used to measure T lymphocytes sub-types of 32 URSA women before and after active immunotherapy and 30 normal early pregnant women were taken as control.Results:Compared with control group,CD4+ cells and CD4+/CD8+ ratio increased significantly in URSA women,but CD8+ cells decreased significantly,there were no significant changes in CD3+ cells between two groups.After active immunotherapy,CD4+ cells and CD4+/CD8+ ratio dropped,but CD8+ cells increased greatly in URSA women,there were still no significant changes in CD3+ cells.Conclusion:The occurrence of URSA might be associated with proliferation of the CD4+ cells and decrease of the CD8+ cells.Markedly dropped CD4+ cells and increased CD8+ cells in URSA women after active immunotherapy is in favor of conception.
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Objective:To investigate the distribution and common reason of abortion for hospitalized women in Cangzhou city,provide scientific foundation for the government to take effective measures to decrease the number of induced abortion and to reduce the abortion rate.Methods:It was conducted in 5 hospitals with the method of across-sectional study,parturient question in hospital and the status description of induced abortion.Results:The proportion of induced abortion was 48.5%,the times of induced abortion ranged from 1 to 6.The youngest age for the first time of abortion was 15 years old;the abortion of unmarried women for the first time was 47.39%;the proportion of induced abortion increased with the age of parturient;unintended abortion became the primary reason of induced abortion.Conclusion:It is found that the proportion of induced abortion in Cangzhou is higher,and has the tendency of young and unmarried wemen induded,and the reason for that is complicated.Scientific and effective measures should be taken to reduce induce abortion rate.
Induced Abortions
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Early embryonic mortality Morphological analysis of spontaneous abortuses Epidemiology of chromosomal anomalies in spontaneous abortion: prevalence, manifestation and determinants Chromosomal abnormalities in spontaneous abortion: frequency, pathology and genetic counselling Maternal age and spontaneous abortion Immunopathological factors contributing to recurrent and spontaneous abortion in humans Congenital abnormalities of the fundus Diethystilboestrol exposure and reproductive performance Infectious agents as a cause of spontaneous abortion Cervical incompetence as a cause of spontaneous abortion Recurrent spontaneous abortion Psychological aspects of spontaneous abortion Principles of management of spontaneous and recurrent abortion.
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Objective To study the status of spontaneous abortion among reproductive wowen aged 20～44 years in Nanchang areas.Methods A cross-sectional survey was conducted on reproductive history of women and the sample was chosen with multistage cluster random sampling technique.Results A total of 5 468 women aged from 20 to 44 years-old in Nanchang were studied with a total of 10 098 pregnancies.There were 396 spontaneous abortion with an incidence rate of 6.04%.The occurrence of spontaneous abortion inreased with the increase of pregnancy and the age of first pregnancy.Conclusion The occurrence of spontaneous abortion increased with the increase of pregnancies.The focus time of spontaneous abortion is 5～10 years after marriage.Occupation is a risk factor of spontaneous abortion.Compared with the historical data there is an upward trend of spontaneous abortion in Nanchang.
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This study tests the hypothesis that state abortion rates are influenced by state restrictions on abortion. Earlier studies have shown mixed results. I develop a model of abortion rates for the time period from 1988 through 1996 and hypothesize that the adoption of abortion restrictions requiring parental involvement for minors, abortion‐specific informed consent, and waiting periods prior to the procedure lead to lower state abortion rates. I further hypothesize that individual four‐year models of the period before and after the Casey (1992) decision will demonstrate that this effect was strongest in the time period after the Casey decision. Analysis of the data confirms the first hypothesis that restrictions have a significant impact on abortion rates while controlling for other factors that influence the abortion rate. The second hypothesis is not confirmed, as the effect is significant prior to the Casey decision.
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Journal Article INDUCED ABORTION AND SPONTANEOUS ABORTION: NO CONNECTION? Get access JENNIE KLINE, JENNIE KLINE 2 1New York State Psychiatric Institute and Division of Epidemiology, Columbia University School of Public Health 2 Reprint requests to Dr. Kline, School of Public Health, Division of Epidemiology, Columbia University, 600 West 168th St., New York, NY 10032. Search for other works by this author on: Oxford Academic PubMed Google Scholar ZENA STEIN, ZENA STEIN 1New York State Psychiatric Institute and Division of Epidemiology, Columbia University School of Public Health Search for other works by this author on: Oxford Academic PubMed Google Scholar MERVYN SUSSER, MERVYN SUSSER 3Division of Epidemiology, Columbia University School of Public Health and Gertrude H. Sergievsky Center, Columbia University Search for other works by this author on: Oxford Academic PubMed Google Scholar DOROTHY WARBURTON DOROTHY WARBURTON 4Department of Pediatrics and Human Genetics, Columbia University Search for other works by this author on: Oxford Academic PubMed Google Scholar American Journal of Epidemiology, Volume 107, Issue 4, April 1978, Pages 290–298, https://doi.org/10.1093/oxfordjournals.aje.a112544 Published: 01 April 1978 Article history Received: 19 September 1977 Accepted: 06 December 1977 Published: 01 April 1978
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One hundred six women were reported to have died from abortions (55 legal, 10 illegal, and 41 spontaneous) in the United States from 1975 through 1977. In reviewing these deaths, the authors developed a new approach to mortality studies. A catalogue was compiled of behavioral factors (including actions by physicians, patients, communities, and institutions) that in the authors' judgment increased the risk of death from abortion. The proportion of abortion deaths to which each behavioral risk factor contributed was determined. Of the 199 different behavioral factors, 5 contributed to more than 10% of legal abortion deaths, 5 to more than 10% of illegal abortion deaths, and 3 to more than 10% of spontaneous abortion deaths. The most frequent factors involved were delay in obtaining a legal abortion until 13 weeks' gestation or later, incomplete abortion, and inappropriate choice of antibiotics for septic abortion. Assessing the proportion of abortion deaths to which each factor contributed can help identify which factors deserve priority in prevention.
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Journal Article SPONTANEOUS ABORTION AND INDUCED ABORTION: AN ADJUSTMENT FOR THE PRESENCE OF INDUCED ABORTION WHEN ESTIMATING THE RATE OF SPONTANEOUS ABORTION FROM CROSS-SECTIONAL STUDIES Get access EZRA SUSSER EZRA SUSSER Send reprint requests to Dr. Susser at the Sergievsky Center, Health Sciences, Columbia U., 630 West 168th St., New York, NY 10032. Search for other works by this author on: Oxford Academic PubMed Google Scholar American Journal of Epidemiology, Volume 117, Issue 3, March 1983, Pages 305–308, https://doi.org/10.1093/oxfordjournals.aje.a113542 Published: 01 March 1983 Article history Received: 20 May 1982 Published: 01 March 1983
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