Influence of surface characteristics on bone integration of titanium implants. A histomorphometric study in miniature pigs
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Abstract The purpose of the present study was to evaluate the influence of different surface characteristics on bone integration of titanium implants. Hollow‐cylinder implants with six different surfaces were placed in the metaphyses of the tibia and femur in six miniature pigs. After 3 and 6 weeks, the implants with surrounding bone were removed and analyzed in undecalcified transverse sections. The histologic examination revealed direct bone‐implant contact for all implants. However, the morphometric analyses demonstrated significant differences in the percentage of bone‐implant contact, when measured in cancellous bone. Electropolished as well as the sandblasted and acid pickled (medium grit; HF/HNO 3 ) implant surfaces had the lowest percentage of bone contact with mean values ranging between 20 and 25%. Sandblasted implants with a large grit and titanium plasmasprayed implants demonstrated 30–40% mean bone contact. The highest extent of bone‐implant interface was observed in sandblasted and acid attacked surfaces (large grit; HCl/H 2 SO 4 ) with mean values of 50–60%, and hydroxylapatite (HA)‐coated implants with 60–70%. However, the HA coating consistently revealed signs of resorption. It can be concluded that the extent of bone‐implant interface is positively correlated with an increasing roughness of the implant surface.Keywords:
Cancellous bone
Hydroxylapatite
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In 286 adults with misalignment of the lower limb the length and torsional angles of the femur and tibia were determined using a method based on computed tomography. Depending on the location of the axial scan values for femoral antetorsion changed substantially. Normal values obtained in non injured extremities by this technique were an internal torsion of 23.5 +/- 8.6 degrees (mean +/- SD) in the femur and an external torsion of 34.9 +/- 8.6 degrees in the tibia. Mean intraindividual side differences in the femur and tibia were 4 degrees, the 95% confidence interval was 11.0 degrees in the femur and 12.3 degrees in the tibia. CT-methods can only be used for the determination of torsional angles in the femur and tibia if reproducible and standardized locations for the acquisition of axial scans are defined.
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The objective of this experiment was to characterize the relationship between growth and skeletal development in commercial broilers as a function of both age and BW. From hatch through 43 d, birds were randomly selected weekly from the same commercial flock for measuring BW, tibia, and femur characteristics. Final BW was 1.8 kg for females and 2.1 kg for males. The fat-extracted weight of the tibia and femur increased proportionately with BW through 43 d of age. Length and width measures as a proportion of their final values at 43 d increased more rapidly than relative changes in BW. The length of the femur as a function of BW reached a plateau at 1.5 kg (35 d of age), whereas the length of the tibia did not plateau through 43 d of age. Differences in width measures between the two long bones were not apparent as BW increased through 43 d of age. The ash percentage of the diaphyseal region (mid-10% of bone) was consistently greater in the tibia than the femur from 15 to 43 d (P < or = 0.05). Differences in mineralization rates and growth characteristics suggest that the functionality and integrity of the femur should not be assumed solely from tibia measurements.
Flock
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In 34 human embryos of 7th and 8th week the length of femur and tibia was measured. It was shown that the length of femur increased from 2.65 mm to 5.10 mm during investigated period. These values for tibia were 2.09 mm and 3.21 mm.
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Anthropometry plays a crucial role in the field of forensic anthropology, particularly in the identification of human remains. Among the various parameters used for personal identification, stature holds significant importance. It is a key factor in medico-legal investigations, especially when dealing with unknown fragmentary and mutilated remains. The objective of present pilot study was to develop a mathematical formula for estimating human stature based on the measurement of long bones, specifically the femur and tibia. A sample of 150 randomly selected girls, aged between 18 and 24 years, was chosen from Nagpur’s Institute of Forensic Science, Maharashtra. The length of the right tibia and femur bones was measured, calculated and regression formulae was derived to estimate stature for the female population of Maharashtra. To assess the relationship between bone length and stature, Pearson's correlation coefficient was employed and revealed regression coefficient (r) of 0.92 for the femur and 0.77 for the tibia, indicating a significant positive correlation between bone length and stature. Consequently, the findings of this study demonstrate that the length of the femur and tibia bones can serve as reliable predictors for estimating the stature of an individual. In conclusion, anthropometric measurements, particularly those involving long bones such as the femur and tibia, hold immense value in the identification of human remains in the field of forensic anthropology.
Forensic anthropology
Long bone
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Apposition
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The aim of this study was to determine whether the dimensions of the distal femur and proximal tibia joint surfaces affect the etiology of knee osteoarthritis (OA). The study comprised the records of 1,324 patients who had been admitted to hospital with knee pain. Anterioposterior (AP) and lateral radiographs of the knee were taken. Using the Kellgren‐Lawrence Scale, the patient group comprised Stages 2, 3, and 4 radiographs and the controls comprised Stages 0 and 1 radiographs. Four lengths were measured for each patient in both groups: femur mediolateral (femur ML), tibia mediolateral (tibia ML), femur anteroposterior (femur AP), and tibia anteroposterior (tibia AP). Osteophytes were not included in the measurements in the patient group. All the measurements were repeated by two researchers at two different times. The groups were compared in terms of these measurements and the correlations between them. The mean femur ML length was significantly greater in the patient group than the control group ( P = 0.032) and the mean femur AP length was significantly less ( P = 0.037). In addition, the difference between the femur ML and AP lengths was significantly high in the patient group ( P < 0.001). The difference between the tibia and femur ML lengths was significantly high in the patient group ( P < 0.001) and the difference between the tibia and femur AP lengths was higher in the control group ( P = 0.001). A longer femur ML and a shorter femur AP, together with a greater difference between these two lengths and a greater difference between the tibia ML and femur ML lengths, could be a risk factor for developing knee OA. More extensive anatomical and biomechanical studies in the future will enable these results to be corroborated. Clin. Anat. 28:672–677, 2015. © 2015 Wiley Periodicals, Inc.
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Immobilisation of the one hind leg in adult male rats was followed by characteristic changes of the bone mass and the percentage composition of the tibia and the femur of the immobilised leg. These changes were studied during an immobilisation period of 1 to 24 weeks. The tibia of the immobilised leg showed significant loss of bone mass expressed as a decrease of its organic and ash weights as compared with the tibia of the non-immobilised leg. There was a significant increase of its percentage water content and significant decrease of its organic and its ash contents. The specific activity of the tibia was increased throughout but the increase was independent of time. The observed changes in bone mass and in percentage composition of the femur of the immobilised leg were almost identical with those of the immobilised tibia. The specific activity of the femur showed a positive almost linear regression. There were observations indicating that the skeletal changes recorded for the tibia were progressive during the period of observation. The changes noted in the femur seemed to be stabilised or even somewhat declining towards the end of the experiment.
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This study aimed at comparing the growth and mineralization of the femur, tibia, and metatarsus of male and female broiler chicks. On the day of hatch, 100 male and 100 female Ross 308 broiler chicks were transferred stainless cages with 10 birds per cage. On d 7, 14, 21, 28, 35, and 42, five males and five females were sacrificed and their femur, tibia, and metatarsus were collected. Results showed that the tibia was the heaviest and the longest and contained the highest content of ash and calcium (Ca) among the three leg bones. The femur had the greatest diameter. The weight, length, diameter, and ash weight of the femur, tibia, and metatarsus linearly increased with age. The ash, Ca, and phosphorus (P) content in the femur and the tibia quadratically increased with age; by contrast, these parameters in the metatarsus linearly increased with age. The bones grew faster in 1 to 21 d of age. The weight, diameter, and ash weight of the three bones of males were higher than those of females. The Ca to P ratio of the three bones (femur, tibia, and metatarsus) was approximately 2.0:1. These data indicate that there are differences in bone growth and mineralization among the femur, tibia, and metatarsus of male or female broiler chicks.
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