Improved long-term survival with combined modality therapy for pediatric nasopharynx cancer
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Patients with a known primary malignancy and one or more suspicious skeletal lesions are often assumed to have skeletal involvement by the known malignancy. We set out to determine how often one would be correct in making this assumption.All CT-guided bone biopsies performed at our institution between January 2006 and January 2009 in patients with a history of a single biopsy-proven malignancy were retrospectively reviewed. Pathology results were assigned to one of three outcomes: skeletal involvement by known malignancy, newly diagnosed malignancy, or no malignancy identified. Patients categorized as no malignancy identified required repeat biopsy or stability on follow-up imaging for confirmation.Of 104 patients with a known primary malignancy, 11 were excluded. Of the 93 included patients, there was skeletal involvement by the known malignancy in 82 (88%), a newly diagnosed malignancy in seven (8%), and no malignancy identified in four (4%).Biopsy of a suspicious skeletal lesion in a patient with a solitary known malignancy reveals a newly diagnosed malignancy or no evidence of malignancy in 12% of patients, emphasizing the importance of biopsy.
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Objective:To investigate the clinical features in patients with NKTLNT,the treatment response between radiotherapy as initial treatment and chemotherapy as initial treatment,and the influence of different therapy on 5-year survival.Methods:The deta of 57 patients with Ann Arbor stage IE NKTLNT who underwent radiotherapy+chemotherapy,or chemotherapy+radiotherapy,were retrospectively reviewed.These patients were divided into two groups according to initial treatment:radiotherapy alone or radiotherapy+chemotherapy group(n=35 patients) and a chemotherapy+radiotherapy group(n=22 patients).The treatment response,and survival data for the patients were compared between this two groups.Results:There was no significant difference in the clinical profiles between the two groups.26 patients(74%) in the radiotherapy plus chemotherapy group achieved complete response after initial treatment,whereas only 5 patients(23%) in the chemotherapy plus radiotherapy group achieved complete response.But Compared with the patients in the chemotherapy+radiotherapy group,those in the radiotherapy+chemotherapy group had a similar 5-year overall survival rate(61.9% for the radiotherapy+chemotherapy group vs.55% for the chemotherapy+radiotherapy group).Conclusions:NKTLNT do not have specific symptoms which can help for early-stage diagnosis,and radiotherapy as initial treatment can achieve better treatment response,but our research does not get an increased 5-year overall survival rate in the radiotherapy+ chemotherapy group.
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Blood stasis syndrome,which commonly exists in patients with malignant tumor,is not only a objective sign in cancer,but also plays an important role in the growth,invasion and metastasis of malignant tumor. Operation,radiotherapy and chemotherapy are the main treatments of cancer and all of these three treatments can reduce the tumor and relieve the symptoms.Therefore,operation,radiotherapy and chemotherapy can ease the patients' blood stasis state to a certain extent. However,operation,radiotherapy and chemotherapy may cause some damage to the body and can effect the stasis syndrome in the different time of treatment process. So,operation,radiotherapy and chemotherapy may have the potential promote to the invasion and metastasis of malignant tumor through effect the blood stasis state. Therefore,using blood-activating herbs in the different time of operation,radiotherapy and chemotherapy may have different effects on the tumor invasion and metastasis.
Blood stasis
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Objective To retrospectively analyze and evaluate the outcome of malignant cerebral glioma treated by chemotherapy plus radiotherapy.Methods A total of 126 patients with malignant cerebral glioma were retrospectively studied.Sixty-four patients in the radiotherapy group were irradiated with DT54-60 Gy,62 patients in the chemotherapy plus radiotherapy group were given chemotherapy(VM-26 and Me-CCNU)after exposure to DT 20 Gy.The 1-,3-and 5-year survival rates of these patients were compared.Results The 1-,3-,and 5-year survival rates of the radiotherapy group were 64.06%,31.25%,and 15.63% respectively,while the 1-,3-,and 5-year survival rates of the chemotherapy plus radiotherapy group were 80.65%,50%,and 30.65 % respectively(P 0.05).Conclusion Combination of chemotherapy and radiotherapy is effective and well-tolerated in the treatment of malignant cerebral glioma.
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Objective To explore the value of MSCT features in predicting the malignancy degree of gastrointestinal stromal tumor(GIST).Methods CT Data of 44 patients with pathologically proved GIST were reviewed.The differences of CT features among different malignancy degrees of GIST were analyzed.Results Pathology confirmed very low malignancy GIST in 5 patients,low malignancy in 9,moderate malignancy in 7 and high malignancy in 23.The tumor size,location,growth pattern,enhancement pattern,contour,mesenteric fat infiltration,cystic-necrosis,tumor vascularization and direct organ invasion had statistical differences among different malignancy degrees(all P0.05).Conclusion Tumor size,location,growth pattern,enhancement pattern,border,mesenteric fat infiltration,cystic-necrosis,tumor vascularization and direct organ invasion might be predictive indexes for malignancy of GIST.
Stromal tumor
Infiltration (HVAC)
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Breast cancer is one of the most common malignancies in women worldwide. It can be treated with surgery combined with chemotherapy and radiotherapy.This study aims to investigate the effects of chemotherapy and radiation therapy on blood cell components of breast cancer patients who survived one of these therapies, in Al-Amal National Hospital for Cancer Management. Numbers of blood cells including white blood cell (WBC), red blood cell (RBC) and lymphocytes, and hemoglobin (HGB) concentration were measured in thirty-two women with eighteen of them treated with chemotherapy and the left treated with radiotherapy.The results showed that the counts of WBC, RBC and lymphocytes decreased faster in the patients treated with chemotherapy compared to that in the patients treated with radiotherapy, whereas HGB concentrations only slightly changed with both treatments, upon four cycles of each treatment. These results support that radiotherapy may cause less side effects on breast cancer patients compared to chemotherapy.
White blood cell
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Objective To study the chemotherapy effect of apoptosis of osteosarcoma and its relationship with prognosis.Methods The survival rate and the rate of lung metastasis were compared between chemotherapy group and none-chemotherapy group by retrospective study on 53 osteosarcoma samples in human,and apoptotic body and expression of cyclin D1 in osteosarcoma were detected by using histological observation and immuneohistochemistry (SP).Results The 3 years and 5 years survival rates and apoptosis rate of chemotherapy group were apparently higher than those of none-chemotherapy group (P0.05);the rate of lung metastasis and positive rate of cyclinD1 of chemotherapy group were significantly lower than those of none-chemotherapy group (P0.05);The apoptosis rate has positive correlation with the 3 years and 5 years survival rate.Conclusions Chemotherapy can increase survival rate of osteosarcoma significantly;The chemotherapy effect obtained mainly by inducing apoptosis and suppressing cell proliferation;Apoptosis rate of tumor is an important factor that influences the prognosis of osteosarcoma.
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Induction chemotherapy, followed by surgery and/or radiotherapy was utilized in patients with advanced squamous cell carcinoma of the head and neck. During these trials, the authors observed that response to chemotherapy predicts further response to subsequent radiotherapy. This study was comprised of 57 patients with 60 separate neoplasms who demonstrated less than complete response (partial or no response) to initial treatment with a combination chemotherapy containing cisplatin. Subsequently radiotherapy, either 5000 rad preoperatively or 6600 rad as definitive therapy, was employed. Forty-one of the 42 tumors with initial partial response to chemotherapy also responded to radiotherapy (97.6%). Only one of the 18 tumors that initially failed to respond to chemotherapy subsequently responded to radiotherapy (5.5%). This observation suggests that patients with head and neck cancer sensitive to initial chemotherapy share parameters that are also radiation sensitive.
Induction chemotherapy
Epidermoid carcinoma
Complete response
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Until now, the possibility of radiotherapeutic treatment after a failure of chemotherapy has not been systematically investigated. Eight cases with primary failure of chemotherapy or recurrence after chemotherapy could be evaluated. The patients were submitted to curative irradiation; six of them achieved a total remission, four had recurrences. Thus two patients remain to give an example that radiotherapy can bring about long-term total remissions after primary failure of chemotherapy or recurrence after chemotherapy. When the data were evaluated, the total remission times of the two patients were 12 and 18 months, respectively. The toxicity of radiotherapy was justifiable. It was increased especially in regions that had already been irradiated or if a ABVD therapy was applied a short time before or after the radiotherapy. There are only few communications in literature about the success of a radiotherapy after failure of chemotherapy. Most of the patients mentioned had "remissions" (total/partial remissions?). In most of the cases, there are no indications about the further development. On the whole, the data show that there may be some special indications for radiotherapy in case of a failure of chemotherapy.
ABVD
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Objective:To study the changes of platelet parameter in tumor patients before or after radiotherapy and chemotherapy and the clinic significance.Methods: 31 cases of tumor patients before or after radiotherapy and chemotherapy were selected and their platelet parameters(PLT,PCT,MPV,DPW,P-LCR) were measured by the sysmex SF-3000 complete automatic hemanalysis, then compared with control group.Results: There was no signficant difference between the two groups in the platelet parameters before radiotherapy and chemotherapy(P0.05).The levels of PLT,PCT,MPV,P-LCR in tumor patients after radiotherapy and chemotherapy were significantly lower than that before radiotherapy and chemotherapy(P0.01或P0.05),but PDW is no different(P0.05).Conclusion:Determine of platelet parameters of tumor patients before or after radiotherapy and chemotherapy is of certain clinical significance for observation of the status of their marrow restrained and estimate of state of illness.
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