Monitoring lidocaine single‐crystal dissolution by ultraviolet imaging
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Dissolution behavior of a newly designed, commercially available sustained-release tablet of theophylline containing 50mg (Theodur® 50) was measured according to the J. P. X dissolution test procedures in pH 1.2, 6.8, and pH1.2 adding 0.25% Tween 80 solutions.The following results were obtained: The release from Theodur® 50 was pH-independent, but was much affected by wet and rotating velocity of dissolution test.The required time for 50% dissolution at 100rpm was about 2 times as large as at 200rpm.
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Objective To establish an analytical method for the dissolution of acyclovir tablets and evaluate their intrinsic quality. Methods The dissolution process of acyclovir tablets was determined with FODT-601 fiber-optic medicine dissolution process real time test system. Results The real-time dissolution profiles of acyclovir tablets from 9 manufacturers were determined.There was significant difference in the dissolution profiles.One of the dissolution profiles showed comparatively large intra-batch variance. Conclusion This process analysis can reflect the real dissolution process and can provide useful information for improving the preparation technology and monitoring its stability.
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The U.S.P./N.F. dissolution test (method I or rotating basket method) and the rotating flask technique (RESO-TEST dissolution method) were applied to four commercial prolonged release theophylline dosage forms. The dissolution data obtained were converted into dissolution efficiencies and submitted to a correlation analysis, the result of which demonstrates the equivalency of both methods with respect to the characterization of the dissolution behaviour of the dosage forms tested. It is suggested to consider replacement of the official dissolution technique, the shortcomings of which are well-known from the literature, by the rotating flask technique.
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Abstract Dissolution of the active ingredients is of paramount importance for the successful performance of a dosage form. Dissolution testing is a convenient tool for ensuring intra‐ and interbatch performance compliance of dosage forms. This article focuses on factors influencing drug dissolution from dosage forms, dissolution test designing, and analysis of dissolution data
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OBJECTIVE: To monitor the in vitro dissolution of Dimenhydrinate tablets from different manufacturers by Fiber-optic dissolution monitor, and to investigate the quality of it. METHODS: Detection wavelength was set at 278 nm and calibration wavelength was 550 nm. The dissolution was monitored with 2 mm fiber optic probe at rotation speed of 50 r·min-1. Each dimenhydrinate tablet was dissolved in 900 mL of water at 37 ℃. Dissolution data were collected every 30 seconds. The paddle method was used to determine the dissolution of samples and compared with the method stated in Chinese Pharmacopeia. RESULTS: The results of dissolution monitoring showed the dissolutions of different batches of samples were qualified to the standards of Chinese Pharmacopoeia, but a significant difference was observed in their dissolution curves, i.e there was difference in dissolution process. There was no significant difference in the dissolution of same batches of samples at 45 min using monitor and the method of Chinese Pharmacopeia. But the dissolution curves of them were different from one another. CONCLUSION: Compared with the method of Chinese Pharmacopeia, the fiber-optic dissolution monitor is capable of monitoring the real dissolution process of drug and supplying more complete and accurate details of the dissolution process. It can be used to evaluate in vitro dissolution process of drug.
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