Corrigendum to “Abnormal brain connectivity in first-episode psychosis: A diffusion MRI tractography study of the corpus callosum” [NeuroImage 35 (2007) 458–466]
Gary PriceMara CercignaniGeoff J.M. ParkerDaniel R. AltmannThomas R. E. BarnesGareth J. BarkerEileen M. JoyceMaría A. Ron
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We have noticed an error in the “Methods” section. The error, which has no impact on the results or conclusions reached in the article, is detailed as follows:
The reported gender composition in the article was 8 males and 10 females for the patient group and 6 males and 15 females for the control group. It should have been reported as 10 males and 8 females for the patient group and 9 males and 12 females for the control group. The reported results for the gender comparison in the “Results” section on page 461, first paragraph, line 4 [“There were no significant differences in gender distribution (χ2 = 0.62, df = 1, P = 0.43) ”] still remains true, as this analysis was based on the true gender composition of 10 males and 8 females for the patient group and 9 males and 12 females for the control group. All other analyses incorporating gender also incorporate the true gender values.
Finally, in the section “Diffusing processing and analysis” on page 460, paragraph 2, line 20, “180°” should read “80°”.
We apologize for any inconvenience these errors may have caused.Keywords:
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We present a patient with a recurrent glioblastoma and abnormalities of the corpus callosum seen on diffusion tensor MRI that were not seen on conventional imaging. These abnormalities preceded the development of the tumour. We describe the technique of diffusion tissue signatures to assess tissue infiltration by tumours compared with values from normal volunteers.
Infiltration (HVAC)
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Human brain
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Neuropathology
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Diffusion of the water molecule in the brain is restricted by the white matter fibers. Tensor analysis of the proper diffusion-weighted data set provides quantitative analysis of the white matter diffusion anisotropy as well as fiber tracking (tractography) of the white matter. Preliminary clinical experience of diffusion tensor tractography was assessed.
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This paper reviews basic methods and recent applications of length-based fiber bundle analysis of cerebral white matter using diffusion magnetic resonance imaging (dMRI).Diffusion weighted imaging (DWI) is a dMRI technique that uses the random motion of water to probe tissue microstructure in the brain.Diffusion tensor imaging (DTI) is an extension of DWI that measures the magnitude and direction of water diffusion in cerebral white matter, using either voxel-based scalar metrics or tractography-based analyses.More recently, quantitative tractography based on diffusion tensor imaging (qtDTI) technology has been developed to help quantify aggregate structural anatomical properties of white matter fiber bundles, including both scalar metrics of bundle diffusion and more complex morphometric properties, such as fiber bundle length (FBL).Unlike traditional scalar diffusion metrics, FBL reflects the direction and curvature of white matter pathways coursing through the brain and is sensitive to changes within the entire tractography model.In this paper, we discuss applications of this approach to date that have provided new insights into brain organization and function.We also discuss opportunities for improving the methodology through more complex anatomical models and potential areas of new application for qtDTI.
Fiber tract
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Very preterm birth (before 33 weeks gestation) is associated with the white matter damage, and a common sequel is reduced size and altered shape of the corpus callosum. We used diffusion tensor MRI to assess the corpus callosum in 63 very preterm and 45 term-born young adults. Indices of white matter microstructure [fractional anisotropy (FA) and mean diffusivity (MD)] were obtained for the genu, body and splenium. Very preterm females had higher MD in the genu than term-born females, indicating altered white matter microstructure. This was associated with lower performance IQ. The groups demonstrated different patterns of correlations between verbal learning and tract-specific FA and MD, consistent with the reorganization of white matter structure in adults born very preterm.
Splenium
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Human brain
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Objective:To analyse the shape,fiber structure of normal adult cerebral corpus callosum in living humans by using diffusion tensor tracking.Methods:10 healthy adult volunteers (5men,5 women;age range,24～65 years; mean age 40.9years) were examined with MR diffusion tensor.All data were transferred to a personal computer and were processed with dTV(Tokyo University,Japan).Results:The corpus callosums of all volunteers were observed three dimensionally.The corpus callosum showed lune shape on color sagittal fractional anisotropy map and centipede shape on axial diffusion tensor tracking map.Conclusion:Diffusion tensor tracking is useful for showing the normal adult cerebral corpus callosum, and open a new field for researching cerebral white matter fiber in vivo.
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Poster: ECR 2015 / C-0374 / Role of diffusion tensor MR imaging (DTI) and fiber tractography in preoperative assessment of brain tumours by: S. F. A. A. Elkholy; Cairo/EG
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Diffusion tensor imaging (DTI), a technique capable of examining water diffusion in different tissues and the organisation of white matter tracts, was used to investigate the neuropathology of the corpus callosum in vivo in patients with schizophrenia.Diffusion tensor imaging was performed in 20 schizophrenic patients and 25 healthy controls. Two complementary measures, mean diffusivity and fractional anisotropy, which are considered to be sensitive indices of axonal integrity, were obtained from regions of interest in the genu (anterior) and splenium (posterior) of the corpus callosum.Mean diffusivity was significantly increased and fractional anisotropy significantly reduced in the splenium but not the genu of the corpus callosum in the schizophrenic group compared with controls. There were no significant sex differences in the DTI measures for either the schizophrenic or control group. Clinical variables such as age, duration of illness, dose of antipsychotic medication, and schizophrenic symptoms did not predict the DTI changes in the schizophrenic patients.The presence of DTI changes in the splenium but not the genu of the corpus callosum suggests that there may be a focal disruption of commisural connectivity in schizophrenia. However, these findings do not exclude the possibility of abnormalities in other areas of the corpus callosum or other regions of white matter and further research using different methods of analysis may enable us to clarify this. Diffusion tensor imaging is a valuable tool in investigating the structure of white matter in schizophrenia.
Splenium
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