Crocus sativus L. (Saffron) Extract and its Active Constituents (Crocin and Safranal) on Ischemia‐Reperfusion in Rat Skeletal Muscle
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Saffron and its constituents have been shown to decrease ischemia-reperfusion (I/R) injury in kidney or brain tissues. In this study, the effects of saffron ethanolic extract and its constituents, crocin and safranal, were evaluated in skeletal muscle during I/R injury. Hind limb ischemia was induced using clamping the common femoral artery and vein. After 2 h ischemia, the clamp of the femoral vessels of animals was taken off and the animal underwent 1h reperfusion. Muscle injuries were evaluated by recording of the electromyographic (EMG) potentials and performing some biochemical analysis including thiobarbituric acid reactive substances (TBARS), total sulfhydryl (SH) groups and antioxidant capacity of muscle (using FRAP assay). The ethanolic extract of saffron (5, 20 and 80 mg kg(-1)), crocin (50, 200 and 400 mg kg(-1)), safranal (0.1, 0.25 and 0.5 ml kg(-1)) and normal saline (10 ml kg(-1)) were administered intraperitoneally 1 h prior reperfusion. The average peak-to-peak amplitude during I/R was significantly increased in extract, crocin and safranal groups in comparison with control-ischemic group. Following saffron, crocin and safranal administration, the total SH contents and antioxidant capacity were elevated in muscle flap. The MDA level was declined significantly in test groups. It is concluded that saffron extract and its constituents show a protective effect against lower limb I/R in rat.Keywords:
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Saffron is produced from the stigmas and styles of Crocus sativus flowers and is one of the most expensive spices. In C. sativus , both stigma and style are intensely crimson red in color due to the presence of three major classes of apocarotenoids: crocins, picrocrocin, and safranal. In addition to
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ABSTRACT Saffron, the dried, dark-red stigmata of Crocus sativus L., is the most expensive spice in the world, currently selling for over $2,000/kg. Used for flavoring and coloring food, saffron is also being investigated as an anti-cancer agent, but low productivity (6 kg saffron/hectare) limits availability. New technologies, such as in vitro tissue cultures, are being developed for their utility in increasing the amounts of crocin, crocetin, picrocrocin, and safranal, the main constituents of saffron. Additionally, saffron's pharmacological properties have also been the focus of extensive research. We review the recent advances of the past decade to better understand the growth and physiology of Crocus sativas L. as well as the pharmacological properties of saffron secondary metabolites.
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the purpose of this article is to use literature search engines such as PubMed and sciFinder to locate scholarly journal articles pertaining saffron, its preparation, analysis, and its use in cancer treatments.saffron comes from the dried red stigmas of the Crocus sativus L. flower.Along with its use in cooking and in traditional medicine, it has numerous applications as an antitoxic, anti-oxidant, and anti-cancer agent, due to its secondary metabolites and their derivatives are safranal, crocins, crocetin and dymethyl-crocetin.this study demonstrate that crocus sativus extract (csE) and its major constituents, crocin, and crocetin, significantly inhibited the growth of certain cancer cells while not effecting normal cells.Crocus sativus L. extract should be investigated further as a viable agent in the treatment of prostate, pancreatic or other types of cancer.
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Crocus sativus L. (C. sativus), commonly known as saffron, is used as a food additive, preservative and medicinal herb. It has been considered as an alternative treatment for cardiovascular diseases. C. sativus’ medicinal effects are associated to its major ingredients including crocin, crocetin and safranal. This study found that the cardiovascular effects of C. sativus and its major ingredients may be related to their antioxidant and antiinflammation effects.
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In this review, we introduce the traditional uses of saffron and its pharmacological activities from recent scientific studies. Modern pharmacological findings on saffron are compared with those mentioned in Avicenna's monograph. A computerized search of published articles was performed using MEDLINE, Scopus and Web of Science databases as well as local references. The search terms used were saffron, Crocus sativus, crocin, crocetin, safranal, picrocrocin, Avicenna and ‘Ibn Sina’. Avicenna described various uses of saffron, including its use as an antidepressant, hypnotic, anti-inflammatory, and others. Most of these effects have been studied in modern pharmacology and are well documented. The pharmacological data on saffron and its constituents, including crocin, crocetin and safranal, are similar to those found in Avicenna's monograph. This review indicates that the evaluation of plants based on ethnobotanical information and ancient books may be a valuable approach to finding new biological activities and compounds.
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Crocus sativus L., a member of the Iridaceae family, commonly known as saffron has very much popular as both medicine and spice. Earlier saffron was used as one of the important constituents in opioid preparations for pain relief. Its uses in the treatment of mild-to-moderate depression are well documented. Depression can affect the quality of life of individuals by causing headaches, difficulty in thinking, and loss of interest. Many clinical trials have been conducted for evaluating the efficacy of saffron in depression cases. Almost fifty constituents of C. sativus L are well known. Few of the major constituents include crocin, picrocrocin, and safranal. In the present review, the main focus is on the antidepressant effects of saffron and its major constituents, in which it was found that saffron has substantial effects on depression and anxiety because of double-blind study the data can be trusted.
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Saffron spice also known as Crocus sativus (Saffron crocus) belongs to the family of iridaceae. Many studies have proved its potential role in disease eradication. It has been reported to possess the attributes of a sedative, an anti-asthma, an emmenagogue, an expectorant, and an adaptogenic agent. Crocin, crocetin, and safranal are the most important biochemically active ingredients that were found in different parts of the plants in varying proportions like the peels, fruits, seeds, and rind of Crocus sativus. The in vitro and in vivo studies showed that saffron has got its therapeutic implication in health management via anti-oxidant, anti-microbial, hepatoprotective, and anti-tumour activity. This review attempts to reveal the potential pharmacological properties of Crocus sativus. It also draws attention towards the use of herbs and spices in various ailments without facing the harmful side effects of chemically derived medicine.
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Crocus sativus L. from the Iridaceae family, commonly known as saffron, is a medicinal herb that is widely cultivated in Iran and other countries, such as India and China. The effect of saffron and its elements on anxiety and insomnia shows a promising result. The effect of saffron is similar to the activity of diazepam. Diazepam can be used as benzodiazepines, anxiolytics, analgesics, relaxants, and hypnotic agents. Saffron extracts and their constituents, safranal and crocin (crocin and crocetin hydrolysis products), are shown to affect various neuronal pathways that are relevant to sleep. Research shows that this effect affects the sleep rhythm and triggers for sleep
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Saffron, the most expensive spice in the world, comes from the Crocus sativus stigmas. Saffron grows well in the areas with the cold winters and warm dry summers, which have a positive effect on the quality of the raw material obtained. This explains the interest in saffron cultivation and production in Ukraine. Since 2015, large-scale saffron cultivation for food purposes has been started in various regions of Ukraine. Cultivation methods, environmental factors of different regions differ and directly affect on the composition and quality of biologically active compounds of raw materials. In addition, according to recent pharmacological studies, saffron stigma exhibit a wide range of biological activity: anticancer, anti-inflammatory, antidiabetic, antihypertensive, anticonvulsant and other actions that are caused by the composition of biologically active compounds of the saffron stigmas – crocin, picrocrocin and safranal. Therefore, the aim of the work was to establish the content of crocin, safranal and picrocrocin in Crocus rstigmas grown in different regions of Ukraine in accordance with the requirements of ISO 3632.
For research, we used saffron stigmas (Crocus sativus L.) harvested in Kherson, Zaporizhia, Vinnytsia, Odessa, Chernihiv regions in Ukraine in October 2018 and the sample of commercial saffron from Italy (Migros Bio, 2018). The quality of the raw material was established in accordance with ISO 3632 according to the indicators: weight loss of drying, ash total, content of picrocrocin, crocin and safranal by UV-Vis spectroscopy.
In the saffron samples the weight loss of during and the ash total ranged from 6.7–9.2% to 4.3–6.4%, respectively. The content of picrocrocin ( 257 нм nm) in saffron samples ranged from 90 in Kherson and up to 101 in the Chernihiv sample; safranal content ( 330 nm) ranged from 34 for Chernihiv to 42 in the Kherson sample; crocin content ( 440 nm) of 228 in Vinnitsa and up to 262 in Zaporozhye. The obtained data showed that all samples of Ukrainian saffron belong to the first quality category according to ISO classification. In the commercial sample from Italy, the test showed a high content of safranal (330 nm was 59) and crocin (440 nm was 259). Different values between regions and a commercial sample are usually due to different environmental conditions and cultivation practices.
Crocus sativus is an important medicinal and food plant that has been successfully cultivated in Ukraine for food purposes and is of great economic importance. The quality of Ukrainian saffron from different regions has been determined to ISO 3632. The 2018 crop samples are in compliance with international standards and are of category I. It is important that crocin and safranal exhibit high anticancer and antioxidant activity, so growing in our country stable high content of BACs, makes it possible to use saffron not only in the food industry, but also makes it a potentially relevant raw material for the pharmaceutical industry. This study provides significant information on the quality and prospects of saffron production in Ukraine, as both the food and pharmacological raw materials.
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