Determination of rocuronium and its putative metabolites in body fluids and tissue homogenates
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Aqueous two-phase system
Sugammadex
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Background: Rocuronium may not be preferable for rapid sequence intubation due to its long intubation time compared to Succinylcholine. But, Rocuronium along with 2% Sevoflurane may produce comparable intubating time and conditions to that of Succinylcholine. This prospective, randomised, double-blind study was undertaken to compare the effect of Sevoflurane on intubation time and conditions with Rocuronium. Materials and Methods: 30 adult patients of ASA grade I and II of both sexes aged between 30 to 65 years undergoing neurosurgical operations were randomly allocated into 2 equal groups: one group received 0.8 mg/kg of Rocuronium and 2% Sevoflurane (Group – RS) and other received 0.8 mg/kg Rocuronium (Group – R). Onset time of intubation was assessed using Train of Four stimuli. The intubating conditions were compared by the Cooper scoring system and haemodynamic responses were compared between two groups. Results: The onset time of intubation was 60.4 ± 4.1 s in Group-RS and 101.73 ± 10.28 s in Group-R (P < 0.001), with excellent intubating conditions in both the groups and without any adverse effects. Significant differences in heart rate and mean arterial pressure were seen immediately after intubation, at 1 min, and at 3 mins (P < 0.05) between the two groups. Conclusion: Rocuronium with 2% Sevoflurane provides excellent intubating time and conditions comparable to Succinylcholine.
Rocuronium Bromide
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Rocuronium may not always be the preferred relaxant for rapid sequence intubation. When 2% sevoflurane is used in conjunction with rocuronium, it may reduce the time required for achieving complete skeletal muscle relaxation with the intubating dose of rocuronium.This study was prospective, randomised, double-blind in nature and compared the effect of sevoflurane on intubation time and intubating conditions when used along with rocuronium. Thirty adult patients belonging to American Society of Anesthesiologists physical status Grades 1 and 2, of either gender aged between 30 and 65 years undergoing neurosurgical operations were randomly allocated into two equal groups: Group R received 0.8 mg/kg rocuronium, and Group RS received 0.8 mg/kg of rocuronium with 2% sevoflurane. Onset time of intubation was assessed using train-of-four stimuli. The intubating conditions were compared using the Cooper scoring system and the haemodynamic responses were compared between the two groups.The onset time of intubation was 101.73 ± 10.28 s in Group R and 60.4 ± 4.1 s in Group RS (P < 0.001), with excellent intubating conditions in both groups and without any adverse effects. Significant differences in heart rate and mean arterial pressure were seen immediately after intubation, at 1 and 3 min (P < 0.05) between the two groups.Rocuronium 0.8 mg/kg along with 2% sevoflurane provides excellent intubating conditions within 60-66 s from its administration.
Rocuronium Bromide
Muscle relaxation
Muscle relaxant
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Objective To evaluate the performance of target-controlled infusion system for rocuronium in different sex patients.Methods 60 patients(ASA Ⅰ~Ⅱ)scheduled for selective surgical procedure under general anaesthesia were studied.The patients were divided into two groups equally,Man group(Group M) and Woman group(Group W).The target effective site concentration of rocuronium for intubation was 6 in each group;and the target effective site concentration during operation was 0.8 μg/ml,and was increased or decreased by 0.2 μg/ml to maintain 10%≥T1/TC0.The effective time,recover time,target rocuronium concentrations and blood rocuronium concentrations were recorded in intubation(T1),20 min after TCI(T2),40 min after TCI(T3) and end of operation(T4).Results The effective time of group W was significant shorter than group M(P0.05).The recover time and recover index of group W were significant longer than group M(P0.05).Target rocuronium concentrations and Blood rocuronium concentrations of group M were significant higher than group W in T1,T2,T3 and T4(P0.05).Conclusion The influence of patients sex on TCI of rocuronium is significant,but the mechanism need to study further.
Target controlled infusion
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Sugammadex
Anaphylactic reactions
Rocuronium Bromide
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Rapid sequence induction
Rocuronium Bromide
Pain medicine
Sequence (biology)
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The main clinical use of the neuromuscular blocking agents is an adjuvant in surgical anaesthesia to obtain relaxation of skeletal muscle, particularly of the abdominal wall, to facilitate surgical manipulations. Rocuronium can be used instead of suxamethonium to provide rapid muscle paralysis during tracheal intubation but the recovery is much slower. Rocuronium is administered intravenously to infants and children. In infants, rocuronium is administered at a dose of 450 µg/kg for providing muscle relaxation for laryngeal intubation. To provide sustained paralysis, rocuronium is given at a dose of 600 µg/kg. In children, the neuromuscular blockade is obtained with 600 µg/kg followed by an intravenous infusion of 150 µg/kg per hour. For assisted ventilation in intensive care, rocuronium is administered at a dose of 600 µg/kg followed by an intravenous infusion of 300 to 600 µg/kg per hour. The effects of rocuronium have been extensively studied in infants and children. Rocuronium is converted into 17-desacetyl rocuronium. The pharmacokinetics of rocuronium have been studied in infants and children and the mean residence time is 55.6 and 25.6 min (P-value < 0.01) in infant and children, respectively. Rocuronium interacts with drugs, the treatment of infants and children with rocuronium has been studied, and rocuronium poorly crosses the human placenta. The aim of this study is to review the published data on rocuronium dosing, pharmacokinetics, and treatment in infants and children, and rocuronium metabolism and transfer across the human placenta.
Rocuronium Bromide
Muscle relaxation
Pharmacodynamics
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Rocuronium Bromide
Alfentanil
Adductor pollicis muscle
Bolus (digestion)
Neuromuscular transmission
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Background: The purpose of our study was to determine whether a smaller dose of rocuronium than previously reported could provide similar intubating conditions to suxamethonium during rapid‐sequence induction of anaesthesia in children. Methods: One hundred and twenty ASA I, unpremedicated children, aged 1–10 years, who were undergoing elective surgery, were randomized into three groups to receive rocuronium 0.6 mg·kg –1 , rocuronium 0.9 mg·kg –1 or suxamethonium 1.5 mg·kg –1 . The study was double‐blinded, anaesthesia and timing of injection was standardized to alfentanil 10 μg·kg –1 , thiopentone 5 mg·kg –1 and the study drug. Intubation was attempted at 30 s after injection of neuromuscular relaxant and intubating conditions graded as excellent, good, poor or impossible. Results: All 120 children were successfully intubated within 60 s without need for a second attempt after administration of neuromuscular relaxant. Differences between suxamethonium and rocuronium 0.6 mg·kg –1 and between the two doses of rocuronium were statistically significant ( P =0.016 and 0.007, respectively). Conclusions: Rocuronium 0.9 mg·kg –1 provides similar intubating conditions to suxamethonium 1.5 mg·kg –1 during modified rapid‐sequence induction using alfentanil and thiopentone in children ( P =0.671). Rocuronium 0.6 mg·kg –1 was inadequate.
Alfentanil
Rocuronium Bromide
Rapid sequence induction
Muscle relaxant
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