Effect of Suckling on Plasma Prolactin and Hypothalamic Monoamine Levels in the Rat
86
Citation
0
Reference
10
Related Paper
Citation Trend
Abstract:
In lactating rats that were separated from their pups for 8 hours, suckling induced a rapid rise in plasma prolactin levels. Correlatively, it induced a depletion in dopamine (DA) and serotonin (5-HT) concentrations within the hypothalamus as early as 5 min after the onset of suckling. This depletion lasted as long as the stimulus was maintained. A parallel increase in the level of the metabolite of 5-HT, 5-hydroxyindolacetic acid (5-HIAA), was observed. Under these conditions, the ratio of 5-HIAA/5-HT is augmented. This ratio is a good index of turnover of the transmitter. Suckling affected neither the content of noradrenaline (NA) in the hypothalamus nor the levels of any amine tested in the cerebral cortex. When pups were separated from their mother for 24 hours, suckling no longer resulted in changes in either plasma prolactin levels or hypothalamic DA, 5-HT, or 5-HIAA concentrations. We have concluded that the activation of a discrete system of 5-HT containing neurons is associated with the triggering effect of suckling on prolactin release. (Endocrinology99: 445, 1976)Keywords:
Plasma levels
Human growth hormone
Non human primate
Cite
Citations (14)
Depression
Cite
Citations (37)
The concentration of serotonin in platelet-poor plasma was measured with a radioenzymatic method in 31 patients prior to operation for suspected acute appendicitis. The serotonin determinations were made without knowledge of the peroperative or histologic findings. Appendicitis was found in 20 patients, nine of whom had elevated plasma serotonin level, giving 45% sensitivity for the test. Of the 11 patients with normal appendix, only one had increased plasma serotonin, giving 91% specificity. The predictive value of normal serotonin level was 48% and that of elevated serotonin level was 90%. No correlation was found between duration of appendicitis symptoms and plasma serotonin concentration. Other diseases did not influence the serotonin level.
Plasma levels
Cite
Citations (16)
Monoaminergic
Cite
Citations (5)
Pituitary prolactin has been quantified by radioimmunoassay in whole milk obtained from cattle, goats, sheep and rats. Prolactin concentrations in milk samples obtained following the completion of lactogenesis approximate concentrations of the hormone in blood plasma or serum. However, concentrations of prolactin in prepartum mammary secretions were much higher than plasma prolactin in prepartum dairy cows. This observation was consistent with the hypothesis that during mammary lactogenesis, endogenous milk prolactin in the alveolar lumen may be an additional source of biologically active prolactin. The value of milk prolactin to neonatal animals remains unknown. Experiments with milk-fed calves and suckling rats failed to demonstrate absorption of the intact molecule into the neonate's blood. Further research is needed to determine the role, if any, that maternal prolactin consumed in milk plays in neonatal physiology. Measurements of milk prolactin seem to be highly predictive of the average blood prolactin concentration. Milk prolactin can probably be used in lactating females to predict average plasma prolactin in a manner that is relatively independent of stress- or milking-induced increases in pituitary release of the hormone.
Milking
Prolactin cell
Blood plasma
Cite
Citations (60)
This study aimed to investigate the effects of Chaihushugansan and Chaihuyigantang on the change of monoamine-contents in the hypothalamus of mice induced by the immobilization stress. Each formula(1.0g/kg) was injected intragastrically to mice 1 hour prior to the immobilzation stress(15 minutes) before measuring the change of monoamine-contents level in mice hypothalamus. The results were as follows: 1. DA content at control group showed significant change. CHSGS group and CHYGT group showed significant decrease.(P
Cite
Citations (2)
Objective:To observe the changes of monoamine neurotransmitter contents in hypothalamus of aging rats.Methods: The sub-acutely aging rats were made by injecting D-gal into the rats' abdominal cavity continually and the monoamine transmitter contents in hypothalamus were detected with HPLC-ECD. Results:The NE, DA, 5-HT contents in hypothalamus of aging rats decreased significantly compared with normal rats (P0.01). Conclusions: The monoamine neurotransmitter contents in brain of D-gal aging rats decreased significantly, this maybe one of the mechanisms that D-gal inducing aging.
Cite
Citations (0)
Prolactin cell
Cite
Citations (21)
Cite
Citations (8)
Using the liquid chromatography of high pressure method the authors observed that the low doses of irradiation (0.4-0.8 Gy) increased the content of monoamines in rat hypothalamus. This effect depends on influence of gaseous-hypoxic mixture during the irradiation.
Cite
Citations (0)