A prospective study of incidence, clinical and quality of life consequences of oral mucositis post palifermin prophylaxis in patients undergoing high-dose chemotherapy and autologous hematopoietic cell transplantation
Ioanna SakellariMaria K. AngelopoulouΌλγα ΤσοπράIoannis DervenoulasPanagiotis TsirigotisAlexandros SpyridonidisMaria LigaKonstantinos TsionosKonstantinos AnargyrouAnastasia PouliΑchilles Anagnostopoulos
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Introduction: Mucositis is an inflammatory illness that affects the mouth’s mucous membranes. It could be the result of an infection or an indication of something more serious. Oncology nurses play a crucial role in improving patient outcomes related to oral mucositis. Honey has long been used to prevent and cure oral mucositis. Aim: The aim of the study to assess effectiveness of topical application of pure honey on radiation induced mucositis in cancer patients undergoing radiotherapy. Material and Methods: The style adopted for the study is true experimental design with two group pre-tests with the experimental analysis approach was wont to judge the effectiveness of topical applications of pure honey on radiation evoked mucositis patients. This study was conducted in GSL Cancer hospital Rajahmundry. The sample size consisted of sixty patients suffering type oral mucositis patients who are admitted in GSL cancer hospital at Rajahmundry. Sample random sampling technique was used for the choice of sample. Knowledge was collected by mistreatment WHO mucositis assessment scales & one observation check list to assess the grade of radiation induced mucositis in patients. Modified WHO oral mucositis assessment scale. Data were analysed using descriptive and inferential statistics. Result: The results of this study showed that, oral mucositis score of experimental and control groups mean were 9.73 and1.7 respectively. The standard deviation was 0.927 and 14.55 respectively. Hence calculated t’ value 2.66 is greater than tabulated‘t’ value 2, ‘p’ value is 0.0101 shows that there was a significant oral mucositis scores between post test scores in both experimental and control groups. Applications of pure honey was effective. Conclusion: The findings of the study concluded that, the application of pure honey was effective on radiation induced mucositis in cancer patients undergoing radiotherapy and the level of mucositis is decrease.
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To investigate the prevalence and treatment of oral mucositis caused by concurrent chemoradiotherapy and/or molecular targeted therapy in the patients with advanced squamous cell carcinoma of the head and neck.A retrospective study of the incidence and treatment of oral mucositis was performed in 179 patients (155 male and 24 female;124 patients at stage III and 55 patients at stage IV) receiving concurrent chemotherapy and (or) molecular targeted therapy between November 2007 and November 2010. Grade I, II, III and IV oral mucositis occurred respectively in 49, 50, 67 and 13 patients. All the patients received oral mucositis prophylaxis. After the occurrence of oral mucositis, conventional treatment of mucositis combined with quinolone antibiotics were applied.Of the patients, 99 patients with grade I or II and 4 patients with grade III oral mucositis were effectively managed by conventional treatment; 76 patients with grade III or IV oral mucositis were also significantly controled by conventional treatment plus antibiotics. After the treatments, all patients with oral mucositis were under control, with the decrease in the grade of oral mucositis, the reduction of oral pain and the improvement in ability to eat. None of them had radiation treatment breaks.Combined modality therapy can effectively control chemoradiation-induced oral mucositis in patients with head and neck squamous cell carcinoma, grade I and II oral mucositis were cured by conventional treatment and quinolone antibiotics play a key role in the treatments for grade III and IV oral mucositis.
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Introduction: The present study was conducted to evaluate oral mucositis in oral cancer patients receiving head and neck radiotherapy.
Methods: Sixty oral cancer patients who had received at least 40 grays of radiation were included in the study. Mucositis was scored by oroscopy using WHO scale. Grades of mucositis were then compared with total dose of radiation received by the patients.
Results: The cases were receiving the mean cumulative dose of standard radiation therapy of 2Gy per fraction, 5 fractions per week. All the patients developed oral mucositis. The majority had grade I mucositis, followed by grade III, II and IV. The grade of mucositis was directly proportional to the dose of radiation exposure.
Conclusion: Oral mucositis occurs among all the patients undergoing head and neck radiotherapy and grade of mucositis is proportional to the dose of radiation exposure.
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This study aims to evaluate changes in proteomic salivary profile of patients with oral mucositis after adjuvant cancer treatments.Samples were collected from patients after adjuvant cancer therapies, and were analyzed by means of SELDI/TOF. Patients were separated in two groups: patients affected by mucositis (MUCOSITIS) and patient without mucositis (NO MUCOSITIS). All patients were divided in function of the anticancer treatment: patients who had radiotherapy (MUCOSITIS RADIO), had not radiotherapy (MUCOSITIS NO RADIO), had chemotherapy (MUCOSITIS CHEMO), and those who had not chemotherapy (MUCOSITIS NO CHEMO). Statistical evaluation PCA (Principal Component Analysis) was conducted with the software BIO-RAD Data Manager(™) (Version 3.5).We found the increased peaks of 3443, 3487, and 4135 m/z in MUCOSITIS group, while 6237 m/z was reduced. These same peaks would the same modifications in MUCOSITIS RADIO, while in MUCOSITIS CHEMIO are increased 3443 and 6237 m/z but 3487, 4135 m/z are reduced. These data were confirmed by the PCA.Anticancer therapy influenced the level expression of many salivary biomarkers in mucositis with a good significance. Therefore, 3443, 3487, 4135, and 6237 m/z are good biomarker candidates of oral mucositis.
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Background Mucositis is a disabling effect of radiotherapy in head and neck cancers. There is no current standard on management of radiation-induced mucositis. Honey has been shown to reduce radiation-induced mucositis. Methods A systematic review and meta-analysis were undertaken to assess the ability of honey in reducing the severity of oral mucositis, time to mucositis, weight loss, and treatment interruptions. Results Eight studies were included and showed that honey was significantly better in lowering the risk for treatment interruptions, weight loss, and delaying time to mucositis, but not severity of mucositis. Conclusion There is current evidence that honey is beneficial for patients with head and neck cancers by decreasing treatment interruptions, weight loss, and delaying the onset of oral mucositis, but not in decreasing peak mucositis score. In light of the results, honey is a reasonable treatment for radiation-induced mucositis, but more randomized clinical trials (RCTs) should be done. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1119–1128, 2016
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Oral mucositis remains a concern in the treatment of head and neck malignancies.This small study included 11 patients treated by hypo-fractionated radiotherapy and assessed for oral mucositis.All patients received a radiation dose of 55 Gy in 20 fractions (2.75 Gy/fraction).At the end of the first week of radiation, three patients had Grade I oral mucositis.During the last week of radiation, most of the patients developed Grade II and III mucositis, 7 (64%) and 4 (36%), respectively.At one month follow-up, 5 (46%) of them had Grade I, while 2 (18%) had developed Grade II mucositis.At three months, 2 (18%) had Grade I mucositis, and none of the patients showed Grade II/III oral mucositis.Grade II oral mucositis was the most common grade found mainly in the last week of radiation therapy.None had Grade IV oral mucositis.
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Chemotherapy is one of the effective methods to treat cancer. However, the chemotherapy agents may cause a series of adverse reactions due to the nonselective characteristics that affect not only tumor cells, but also normal cells. Oral mucositis induced by chemotherapy is a common oral complication caused by chemotherapy in clinic. It brings great suffering to the patients and also interferes with the procedure of chemotherapy. Because of its high incidence in patients receiving chemotherapy and the significant influence, there are more researches on oral mucositis induced by chemotherapy which let us have further understanding of it. This review article will introduce the pathogenesis, risk factors, clinical manifestations, assessments, treatment and prevention of oral mucositis induced by chemotherapy.化疗是目前治疗癌症最有效的手段之一，但由于目前的化疗药物缺乏选择性，既能作用于肿瘤细胞，也能作用于正常细胞，因此造成了一系列的不良反应。化疗性口炎是一种临床上常见的由化疗导致的口腔并发症，它不仅给患者带来极大痛苦，甚至有可能影响患者化疗的顺利进行。由于化疗性口炎在接受化疗的患者中发生率较高且影响重大，因此目前关于化疗性口炎的研究逐渐增加，也使临床医师对化疗性口炎有了进一步认识。本文从发病机制、危险因素、临床表现、评估标准、治疗及预防等方面对化疗性口炎进行综述。.
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It is known that chemotherapeutic agents are not equally stomatotoxic and oral cavity lesions are the most frequent complications encountered in antineoplastic chemotherapy.The objective of this study was to evaluate the occurrence of severe oral mucositis during a chemotherapy treatment and to identify its relationship with the chemotherapeutic class used.This is a longitudinal, prospective, and observational study that used an intensive direct observation technique for assessing the oral clinical conditions and the chemotherapy treatment administered to 105 patients (both children and adolescents).Severe oral mucositis occurred in all the 10 weeks of evaluation (ranging from 16.2 to 31.4%) and the association between the type of chemotherapy and the occurrence of severe oral mucositis is recorded only in the 6th week, with the chance to develop severe oral mucositis being 3.07 (3.85-2.29) times higher in patients underwent chemotherapy with antimetabolites than in those who have not used chemotherapy (p = 0.012).It was concluded that the chemotherapeutic agents most related to severe oral mucositis and to the interruption in chemotherapy are those of the class of antimetabolites, especially the methotrexate and the Ara C.Ribeiro ILA, de Andrade Lima Neto E, et al. Chemotherapy in Pediatric Oncology Patients and the Occurrence of Oral Mucositis. Int J Clin Pediatr Dent 2019;12(4):261-267.
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