Visualization of Sarcoid Choroidal Granuloma by Enhanced Depth Imaging Optical Coherence Tomography
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Purpose: To report, in vivo, on the quasi-histologic characteristics of a sarcoid choroidal granuloma as visualized by Enhanced Depth Imaging Spectral Domain Optical Coherence Tomography (EDI SD-OCT).Methods: A 49 year-old woman showing a choroidal granuloma secondary to sarcoidosis was imaged by EDI OCT.Result: On EDI SD-OCT examination, sarcoid choroidal granuloma appears as a localized hyporeflectivechoroidalthickening. Two weeks after systemic corticosteroids, the thickness of the granuloma decreased from 568 μm to 356 μm. Five months later, it reached 274 μm, and after eleven months, it decreased to 150 μm.Conclusion: EDI SD-OCT allows direct visualization of choroidal granuloma secondary to sarcoidosis and evaluation of lesion regression after treatment.We recently reported on a novel semi-automatic method to study the morphological changes of the ciliary muscle during accommodation using optical coherence tomography [Biomed.Opt.Express 9, 5100 ( 2018)].Here we present an erratum concerning the calculation of the displacement of the ciliary muscle apex vs. the scleral spur, which affects the data described in Section 3.3 but not the main findings of our publication.
Ciliary muscle
Optical Tomography
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Fourier domain
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しわ, きめ, 毛穴, 等の表面形態変化に起因する内部構造変化を解析することは香粧品学のみならず, 皮膚科学, 美容学的にも非常に重要である。しかし, 表面形態は外力や切り出しによって容易に変形してしまうため, 表面形態の変化と内部構造の変化は別々の方法で評価され, その評価値の相関によって両変化の関連を解析する方法が一般に行われている。したがって, 非接触, 非侵襲的に表面構造と内部構造を同時に計測し, 解析する方法が望まれている。われわれは非侵襲的に皮膚を3次元計測することを可能にした次世代の光干渉断層計, FD-OCT (Fourier domain optical coherence tomography) を用いた皮膚内部構造解析に着手している。今回は, その新しいFD-OCT技術の概要と香粧品学的有用性, 将来性について解説したい。
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목ì ê³ ëê·¼ì ë ¹ë´ì¥ íììì ì¤íí¸ë¼ìì ë¹ê°ìë¨ì¸µì´¬ì(spectral domain optical coherence tomography, SD-OCT)ê³¼ íì¥ê°ë³ ë¹ê°ìë¨ì¸µì´¬ì(swept-source optical coherence tomography, SS-OCT)ì 구조-ê¸°ë¥ ê´ê³ë¥¼ ë¶ìíê³ ì íë¤. ëìê³¼ ë°©ë² ìì¼ê²°ì ì ê°ë°©ê°ë ¹ë´ì¥ê³¼ ìë°ê°ë°©ê°ë ¹ë´ì¥ íì ì¤ ìì¶ì¥ê¸¸ì´ 28 mm ì´ìì ê³ ëê·¼ì 43ì, ìì¶ì¥ê¸¸ì´ 21 ì´ì 24 mm 미ë§ì¸ 30ìì ëìì¼ë¡ íí¥ì ì°êµ¬ë¥¼ ì§ííìë¤. ìì¼ê²ì¬ì ìì¼ê°ëì mean deviation (MD), SD-OCTì SS-OCTë¡ ë§ë§ì ê²½ì¬ì 층 ëê»ë¥¼ 측ì íì¬, 구조-ê¸°ë¥ ê´ê³ë¥¼ ë¶ìíìë¤. ê²°ê³¼ ê³ ëê·¼ìììì SS-OCTì íê· ë§ë§ì ê²½ì¬ì 층 ëê»ì íê· ìì¼ê°ëë ì ìí ìê´ê´ê³ë¥¼ ë³´ìê³ (p<0.001), 6ê°ì 구ììì ì ìí 구조-ê¸°ë¥ ê´ê³ë¥¼ ë³´ìë¤(p<0.05). ê³ ëê·¼ìììì SD-OCTì íê· ë§ë§ì ê²½ì¬ì 층 ëê»ì íê· ìì¼ê°ë ë° 2ê° êµ¬ìì ì ì¸íê³ ë ì ìí ê´ë ¨ì±ì ë³´ì´ì§ ììë¤. ë¹ê³ ëê·¼ìììì SS-OCTì íê· ë§ë§ì ê²½ì¬ì 층 ëê»ì íê· ìì¼ê°ë ë° MDë ì ìí ê´ê³ë¥¼ ë³´ìê³ (pâ¤0.001), SD-OCTì íê· ë§ë§ì ê²½ì¬ì 층 ëê»ì MDì ì ìí ê´ë ¨ì±ì ë³´ìë¤(p=0.036). ë¹ê³ ëê·¼ìììì SS-OCTì SD-OCTì ë§ë§ì ê²½ì¬ì 층 ëê»ì ììíë ìì¼ê°ëë 4ê° êµ¬ììì ì ìí ê´ê³ë¥¼ ë³´ìë¤(p<0.05). ê²°ë¡ ê³ ëê·¼ì ë ¹ë´ì¥ íììì SS-OCTë SD-OCTì ë¹êµíì¬ ìëì ì¼ë¡ ì°ìí 구조-ê¸°ë¥ ê´ê³ë¥¼ ë³´ìë¤. Keywords: Glaucoma, High myopia, Spectral domain optical coherence tomography, Structure-function relationship, Swept-source optical coherence tomography
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We have developed a Micro- optical coherence tomography (μOCT) for in vivo use. We extended line width of the light source and have achieved a longitudinal resolution of 1.9μm in free space and 1.38μm in tissue. In vivo imaging was conducted using zebra fish larvae and cellular structures such as red blood cells in tail artery can be observed.
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The technology of visualization is widely applied in modeling and simulation (M&S). At first, the principle of simulation visualization is introduced. Then aspects of visualization technology applied in M&S are mainly discussed in this paper, that are, modeling visualization, simulation experiment visualization, simulation result analysis visualization and simulation management visualization. The applications cover all the M&S activities. Modeling visualization includes visualization of models and modeling process, model visualization is elaborated in system models, environment models, relationships and interactions between models, simulation experiment visualization consists of experiment original state visualization and experiment procedure visualization, simulation result analysis visualization is presented with technology of visualization applied in result visible and result analysis and evaluation, visualization management of simulation data and models, experiment design, state stakeout, human computer interaction and manual intervention show the management visualization in simulation.
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