Biopolymer-based delivery systems for advanced imaging and skeletal tissue-specific therapeutics
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mTc (CO)3-EC] was prepared and its biodistribution in mice was studied. Biodistribution study revealed that it had pretty high initial kidney uptake and fast renal clearance. It would be helpful for further study of carbonyl technetium core used in the field of kidney imaging agents.
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Objective
To synthesize N- (5-nitroindazole-3-formyl) tyrosine sodium and investigate its hypoxic radiosensitizing effect and biodistribution.
Method
Synthesized the target compound (N- (5-nitroindazole-3-formyl) tyrosine sodium) using condensing agents, and investigated its radiosensitization under hypoxia using H22 xenograft models and its biodistribution using radioactive iodine labeling.
Results
The synthesis and structure of the target compound were confirmed. Xenograft models showed that it had a certain radiosensitizing activity and the mean value of sensitization enhancement ratio was 1.5. Biodistribution experiment revealed that it had a good distribution manner, the distribution ratios of tumor to the nervous system and muscle were both greater than 5.
Conclusion
N- (5-nitroindazole-3-formyl) tyrosine sodium had good radiosensitizing activity and biodistribution manner, and it was worthy of further study.
Key words:
N- (5-nitroindazole-3-formyl) tyrosine sodium; Neoplasms; hypoxic radiosensitization; biodistribution
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Radiosensitizer
Sodium pump
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This pilot study aimed at investigating the safety and feasibility of pre-augmentation soft tissue expansion (STE). Tissue expanders of different sizes (from 240 to 1300 mm3) were implanted subperiosteally in four patients requiring vertical and/or horizontal bone augmentation, and left in situ for 20-60 days, according to the expander size. Guided bone regeneration was carried out after STE completion. Horizontal and vertical bone gains were analyzed through CBCT. Optical scanning and superimposition of cast models were used for volumetric analysis. The mean soft tissue volume increase was 483.8 ± 251.7 mm3. Horizontal bone gain averaged 3 mm in two successfully expanded sites while one case had a vertical bone gain of 8 mm. Despite promising outcomes in bone and soft tissue gain, the present technique needs improvement before being applied routinely in everyday dental practice.
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金 nanoparticles (AuNPs ) 的 biodistribution 是仔细与毒物学的效果有关并且因为他们的潜在的申请，担心大。与为液体运输的新奇解剖、组织学的结构的发现，然而，内在的机制包含了在在里面 AuNPs 的 vivo 运输和 biodistribution 要求进一步深入的调查。在当前的学习，在腱，容器，和神经纤维的一个焦点的点可以最佳地与另外的遥远的结缔组织连接的地方，我们在跗骨的隧道在 intervaginal 空间注射(ISI ) 以后在老鼠调查了 10-nm AuNPs 的 biodistribution。AuNPs 的静脉内的注射(IVI ) 用作控制。血和机关与诱导地联合的血浆团 spectrometry (ICPMS ) 为 Au 分发的定量分析在注射以后在 5， 15，和 30 min 并且在 1， 4， 12，和 24 h 被收集。IVI 和 ISI 产出显著地不同的结果：在在 ISI 以后的血的 AuNP 内容在 IVI 以后是比那低得多的；在肺，心，和肠是类似的；并且在皮和肌肉是更高的。这些调查结果被 AuNP 内容和相对机关 AuNP 分发比例的比率支持。我们表明的结果一快，直接并且发行量无关的 AuNP 器官运输小径，它可以改进我们生理、病理学的 biodistribution 的理解在生物系统处理。而且，这些结果提供新奇卓见进在里面 vivo 运输和 AuNPs 的 biodistribution，它可以导致新奇、有效治疗学并且管理策略。
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soft tissue limitations are encountered in implant dentistry, due to the loss of alveolar bone. The aim of this study is to compare the outcome of soft tissue preparation using Osmed self-inflating soft tissue expanders with different in situ times in two implantation techniques.Osmed self-inflating soft tissue expanders were implanted in goats using a tunnel approach and a flap approach. The animals were sacrificed after 1h (controls) and 40 days (treated). A tattoo technique for stereographic measurements was used to look for soft tissue surface gain. Histological and histomorphometric analyses were performed to quantify and compare the changes in soft tissue volume and bone volume after 1h and 40 days of implantation.after 40 days, the expansion was visible and none of the goats had shown any inflammation. The space between the soft tissue and the bone was filled by the completely expanded expander and surrounding connective tissue. Between the test groups and the control groups, there was no histological difference in the structure of the soft tissue.all the tissue expanders expanded to their maximum size (2.8 times) and were a reliable product for creating a space between soft tissue and bone. The overlying soft tissue remained in excellent shape. There was no difference in the soft tissue volume and the bone volume between the tunnel and the flap approach after 40 days.
Bone tissue
Tissue expansion
Hard tissue
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Osteoporosis is a systemic skeletal disorder characterized by bone loss, which leads to impaired bone strength and an increased risk of fractures. Two million fractures are attributed to osteoporosis annually in the United States and they are associated with serious morbidity and mortality. Bisphosphonates reduce the risk of fracture by suppressing bone resorption and increasing bone strength, and they have been widely used for the prevention and treatment of osteoporosis. However, the use of these drugs for the management of osteoporosis remains a clinical challenge. There are several important considerations including appropriate patient selection, pretreatment evaluation, potential adverse effects, patient preferences, and adherence. This review will discuss the evidence informing the clinical strategy for using bisphosphonates in patients with osteoporosis and those at high risk of fracture, focusing on the benefits and risks of treatment. We will also consider issues related to the monitoring and duration of treatment.
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Bone tissue
Lean tissue
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Osteoporosis is a systemic disorder characterized by low bone mass and microarchitectural deterioration of bone tissue with a consequent increase in bone fragility and susceptibility to fracture. It has a significant impact on public health through the increased morbidity, mortality, and economic costs associated with fractures. Despite the severe medical and socioeconomic consequences of fragility fractures, relatively few adults with fractures are evaluated and/or treated for osteoporosis. In this review, we summarize the existing treatment options and promising new therapies for the prevention and treatment of osteoporosis.
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