Comprehensive analysis of genetic alterations in ovarian cancer
Viji ShridharAjay PanditaJ. Jack LeeSteve IturriaJulie StaubRaji AvulaAmi SenEric S. CalhounFergus J. CouchDavid C. JamesLynn C. HartmannJim LillieJeremy C. Smith
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Journal Article Dinucleotide repeat polymorphisms at the D5S257 and D5S268 loci on chromosome 5p Get access L.E. Bernard, L.E. Bernard Department of Medical Genetics, 6174 University Boulevard, University of British ColumbiaVancouver, BCV6T1Z3, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar C.N. Kreklywich, C.N. Kreklywich Department of Medical Genetics, 6174 University Boulevard, University of British ColumbiaVancouver, BCV6T1Z3, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar S. Wood S. Wood Department of Medical Genetics, 6174 University Boulevard, University of British ColumbiaVancouver, BCV6T1Z3, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 19, Issue 20, 25 October 1991, Page 5794, https://doi.org/10.1093/nar/19.20.5794 Published: 25 October 1991
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Mapping of quantitative trait loci (QTL) was used to investigate the genetic architecture of divergence in floral characters associated with the mating system, an important adaptive trait in angiosperms. Two species of Leptosiphon (Polemoniaceae), one strongly self-fertilizing (L. bicolor) and the other partially outcrossing (L. jepsonii), were crossed to produce F2 and both backcross progenies. For each crossing population, a linkage map was created using amplified fragment length polymorphism markers, and QTL were identified for several dimensions of floral size. For each of the five traits examined, three to seven QTL were detected, with independent datasets yielding congruent results in some but not all cases. The phenotypic effect of individual QTL was generally moderate. We estimated that many of the QTL were additive or showed dominance toward L. bicolor, whereas comparison of mean trait values for parental and cross progenies showed apparent overall dominance of L. jepsonii traits. Colocalization of QTL for different dimensions of floral size was consistent with high phenotypic correlations between floral traits. Substantial segregation distortion was observed in marker loci, the majority favoring alleles from the large-flowered parent. A low frequency of male sterility in the F2 population is consistent with the Dobzhansky-Muller model for the evolution of reproductive isolation.
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Journal Article Pstl Polymorphism at the human P 1 450 gene on chromosome 15 Get access A. Haugen, A. Haugen Search for other works by this author on: Oxford Academic PubMed Google Scholar J. Willey, J. Willey 1Laboratory of Human Carcinogeneisis, National Cancer InstituteBethesda, MD, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar A.L. Børresen, A.L. Børresen 2Department of Genetics, Norwegian Radium HospitalOslo, Norway Search for other works by this author on: Oxford Academic PubMed Google Scholar T. Tefre T. Tefre 2Department of Genetics, Norwegian Radium HospitalOslo, Norway Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 18, Issue 10, 25 May 1990, Page 3114, https://doi.org/10.1093/nar/18.10.3114 Published: 25 May 1990
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Arabidopsis DNA hypomethylation mutation, ddm1 , results in a variety of developmental abnormalities by slowly inducing heritable lesions at unlinked loci. Here, late‐flowering traits observed at high frequencies in independently‐established ddm1 lines were genetically characterized. In all of the four late‐flowering lines examined the traits were dominant and mapped to the same chromosomal region, which is close or possibly identical to the FWA locus. The ddm1 ‐induced phenotypic onsets are apparently not random mutation events, but specific to a group of genes, suggesting the underlying epigenetic mechanism. The DNA methylation mutant provide useful system for identifying epigenetically‐regulated genes important for plant development.
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Journal Article Viral K-ras detects two TaqI polymorphisms, one for KRAS1 on chromosome 6 and the other for KRAS2 on chromosome 12 Get access M. Okamoto, M. Okamoto Search for other works by this author on: Oxford Academic PubMed Google Scholar C. Sato, C. Sato Search for other works by this author on: Oxford Academic PubMed Google Scholar N. Tsuchida, N. Tsuchida 1Department of Oral Microbiology, Tokyo Medical and Dental UniversityYushima, Tokyo 113, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar M.C. Yoshida, M.C. Yoshida 2Chromosome Research Unit, Hokkaido UniversitySapporo 060, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar C. Ezawa, C. Ezawa Search for other works by this author on: Oxford Academic PubMed Google Scholar M. Miyaki M. Miyaki Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 16, Issue 5, 11 March 1988, Page 2363, https://doi.org/10.1093/nar/16.5.2363 Published: 11 March 1988
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