Antibody–drug Conjugates: Using Monoclonal Antibodies for Delivery of Cytotoxic Payloads to Cancer Cells
66
Citation
208
Reference
10
Related Paper
Citation Trend
Abstract:
One approach to improving activity of anticancer drugs is to conjugate them to antibodies that recognize tumor-associated, cell-surface antigens. The antibody–drug conjugate concept evolved following major advances, first, in the development of humanized and fully human antibodies; second, in the discoveries of highly cytotoxic compounds ('drugs) linkable to antibodies; and finally, in the optimization of linkers that couple the drug to the antibody and provide sufficient stability of the antibody–drug conjugate in the circulation, optimal activation of the drug in the tumor, and the ability of the activated drug to overcome multidrug resistance. In this article, we will review the considerations for selecting a target antigen, the design of the conjugate, and the pre-clinical and clinical experiences with the current generation of antibody–drug conjugates.Keywords:
Antibody-drug conjugate
Conjugate
Targeted drug delivery
Colon targeted drug delivery system (CTDDS) delivered as both local and systemic delivery of drugs. Local delivery could, for example, allow topical treatment of inflammatory bowel disease (IBD). Treatment could be enhanced when drug delivered to the target site on the colon. Systemic side effects could also be reduced. Colon specific systems is most important delivery of those drug which are normally inactivated in the upper parts of the gastrointestinal tract (GIT). Primary approaches for CTDDS (Colon targeted Drug Delivery System), which includes prodrugs, pH and time dependent systems, Bacterial enzyme dependent colonic DDS and pH and bacterial enzyme dependent colonic DDS. The novel approach of CTDDS, which includes pressure controlled colonic delivery capsules (PCDCS), CODES and osmotic controlled drug delivery are specific technique.
Targeted drug delivery
Cite
Citations (19)
Targeted drug delivery
Cite
Citations (30)
Oral colon targeted drug delivery system can be divided into pH dependent, time-dependent, enzymatic degradation etc. according to the ways of drug delivery. Mechanism of drug delivery, preparation method and application of oral colon targeted drug delivery system were introduced. In addition, it previewed the research direction of colon targeted drug delivery in the future, to provide a reference for the targeted new dosage form.
Targeted drug delivery
Delivery system
Cite
Citations (2)
Antibody-drug conjugates offer the possibility of directing powerful cytotoxic agents to a malignant tumor while sparing normal tissue. The challenge is to select an antibody target expressed exclusively or at highly elevated levels on the surface of tumor cells and either not all or at low levels on normal cells. The current review explores 78 targets that have been explored as antibody-drug conjugate targets. Some of these targets have been abandoned, 9 or more are the targets of FDA-approved drugs, and most remain active clinical interest. Antibody-drug conjugates require potent cytotoxic drug payloads, several of these small molecules are discussed, as are the linkers between the protein component and small molecule components of the conjugates. Finally, conclusions regarding the elements for the successful antibody-drug conjugate are discussed.
Conjugate
Antibody-drug conjugate
Cite
Citations (22)
The last two decades of developments in drug formulations and novel drug delivery systems have been seen as the beginning of a new era leading to increased patient adherence and pharmacological response to the therapeutic regimen. One of the most difficult tasks is efficiency and target‐specific drug delivery or the extent of delivery at any given site of interest. Many currently designed drug delivery systems are precisely tailored to maximize the delivery of a particular form of drug by reducing the degradation or loss of the drug. In case of cancer treatment, the targeted drug delivery is of utmost importance as the anticancer agents are not having the ability to differentiate between healthy and tumor cells resulting in adverse effects and/or systemic toxicity. The targeted drug delivery is thus designed to focus on preventing side effects and encouraging the accumulation of the drug at the targeted site; one such promising drug delivery system is magnetosome drug delivery, i.e., drug delivery using magnetosomes (biological magnetic nanoparticles). In this article, we have summarized the system for design, development, and mode of drug delivery using magnetosomes along with the recent developments made in this field to facilitate the diagnosis and treatment of cancer.
Targeted drug delivery
Cite
Citations (7)
Targeted delivery combined with controlled drug release has a pivotal function in the future of personalized medicine. Target drug delivery system is one of the most considerable novel approach towards drug delivery system. Targated drug delivery seeks to concentrate the medication in the tissues of interest while reducing the relative concentration of the medication in the ultimate tissues thus enhancing therapeutic index and bioavailability at site specific-delivery .Now a days various carrier systems which includes liposomes, niosomes, aquasomes,pharmacosomes, dendrimers, nanoparticles, microspheres, solid lipid nanoparticles, resealed erythrocytes etc. are utilized in target drug delivery system which provide site specific drug delivery. Drug targeting is the principle by which the distribution of drug in organism is maneuverer in manner such that its major fraction interacts exclusively with the target tissue at the cellular and subcellular. The present review deals with the Targeted drug delivery system its advantages, disadvantages, need of Targeted drug delivery system, Types, drug targeted to a specific organ such as Brain, kidney, heart, colon and respiratory tract and research update on Targeted drug delivery system. Various drug carriers which can be used in this advance delivery system are Niosomes, Liposomes, Nanoparticles, Monoclonal Antibodies.
Targeted drug delivery
Niosome
Cite
Citations (0)
In field of medicine oral route is mostly used path for the administration of drug. so, the oral route is not preferred for lower GIT disorder. So, to overcome this problem drug directly targeting to the specific site. In this review article overview on the colon targeting drug delivery system. Colon is the site where drug is targeted on the local site and used for the local colon disease. Colon targeting drug delivery system not just for the local disease but also used for the systemic delivery of the drug such as proteins, therapeutic peptides, anti-asthmatic, anti-hypertensive drug, antidiabetic drug. Now a day number of method are used to formulate CTDDS such as formation of pro drug, coating of polymers etc. colon targeting drug delivery system is a new system for targeting a drug in specific site for enhance the therapeutic effect of poorly absorbed drug. And now a day drug targeted on colon through rectal route. But this route is very painful. In this article discuss about the anatomy of the colon, factor affecting the colon targeting drug delivery system, advantages of colon targeting drug delivery system, limitation of colon targeting drug delivery system and evaluation of the colon targeting drug delivery system. But in this review mainly discuss about the new method used for colon targeting drug delivery system such as Microspheres,carbon nanotube, metal nanoparticles etc
Targeted drug delivery
Cite
Citations (0)
Conjugate
Antibody-drug conjugate
Subclass
Linker
Cite
Citations (16)
In the last two decades colon targeted drug delivery has gained increased importance not just for the deliver drugs for the treatment of various colonic diseases but also for its potential for delivery of proteins and therapeutic peptides. In the past various traditional approaches used for colon targeted delivery like prodrugs, pH, time dependent, and microflora activated systems, have achieved limited success. For successful colon targeted drug delivery, the drug needs to be protected from absorption and/or the environment of the upper gastrointestinal tract and then be abruptly released into the colon. Hence continuous efforts have been made on designing colon targeted drug delivery systems with improved site specificity and versatile drug release kinetics to fulfill different therapeutic needs. In last couple of years few new systems have been developed for colon targeted drug delivery such as pressure dependent systems, CODES™ technology, micrsponges, pectin and galactomannan coating, microbially triggered osmotic systems, lectins and neoglyconjugated etc. which are reported to have better in-vivo site specificity and design rationale than the earlier approaches. This review article gives an overview of various approaches for colonic targeted drug delivery with emphasis on newer systems, their merits and demerits, in vitro/ in-vivo evaluation and market status of such delivery systems. Keywords: Colon targeted, microflora activated, prodrugs, lectin and neoglyconjugates, microsponges, CODES ™ technology
Targeted drug delivery
Cite
Citations (66)