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    Acid phosphatase localization during differentiation in the cellular slime mold Dictyostelium discoideum
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    The cellular slime mold Dictyostelium discoideum undergoes a transition from single-celled amoebae to a multicellular organism as a natural part of its life cycle. A method of cell-cell signaling that controls chemotaxis, morphogenesis, and gene expression has developed in this organism, and a detailed understanding of this signaling system provides clues to mechanisms of intercellular communication in the development of metazoans.
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    60 Co gamma rays can induce germination of the spores of the cellular slime mold, Dictyostelium discoideum , in the absence of heat shock, amino acids, or bacteria food source. About 65% amoebae emergence occurs by 13 hr after a dose of 180 krad.
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    A self-inhibitor of spore germination has been isolated from spores of Dictyostelium discoideum , a cellular slime mold, and chemically characterized as 2-dimethylamino-6-oxypurineriboside.
    Slime Mold
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    Multicellular masses of the cellular slime mold Dictyostelium discoideum, under conditions which ordinarily suppress cell differentiation, develop clusters of stalk cells and spore cells when implanted with Sephadex particles that had been soaked in 5 X 10(-3)M cyclic adenosine monophosphate (AMP). A possible relation exists between oxygen gradients, cyclic AMP gradients, and the pattern of morphogenesis and cell differentiation during fruiting.
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    Citations (37)