P2‐283: Sensitivity of cognition measures in a longitudinal study of healthy elderly, amnestic MCI and mild‐to‐moderate Alzheimer's disease
0
Citation
0
Reference
10
Related Paper
Abstract:
Specific neuropsychological test batteries may be more sensitive to cognitive decline in early Alzheimer's Disease (AD) than general cognition measures like ADAS-cog or CAMCOG. Establishing clinically meaningful change using the most sensitive measures of cognition across the spectrum of dementia severity will aid the evaluation of new interventions. This study examined the ability of the ADAS-cog (total), the CAMCOG (total score and learning memory), Hopkins Verbal Learning Test- delayed recall (HVLT-DR) and the CANTAB computerized cognition battery (Paired Associates Learning[PAL], choice reaction time[CRT] and spatial working memory [SWM]) to discriminate among healthy elderly (HE, n = 31), amnestic mild cognitive impairment (aMCI, n = 20) and mild to moderate Alzheimer's Disease (AD, n = 19) and to detect change in cognitive function over 1 year. In addition to the cognitive tests, functional status (ADCS-ADL) and self-reported memory impairment (EMQ) were assessed at baseline, 6 months and 1 year. CAMCOG total, CANTAB PAL, and HVLT-DR discriminated among HE, aMCI, and AD. CAMCOG learning memory did not discriminate between HE and MCI and CANTAB SWM did not discriminate between MCI and AD. ADCS-ADL scores showed a non-significant trend toward functional decline among AD and aMCI subjects but not among HE. Both Camcog total score and ADAS-cog indicated significant cognitive decline over 1 year among AD subjects but not among MCI subjects. HE and aMCI showed significant learning effects on the PAL total errors at 1 year. Neither HVLT-DR nor SWM showed decline at 1 year for HE or aMCI. AD subjects showed no change in PAL, HVLT DR or SWM at 1 year. Floor effects were observed for HVLT DR and PAL among AD subjects. Measures of episodic memory, like PAL and HVLT-DR may be better suited to screening for cognitive impairment than evaluating treatment outcomes in aMCI over a 1 year period. Longer follow-up may be required to detect progression of cognitive decline in aMCI.Keywords:
Cognitive Decline
Objective: The authors examined the utility of the computerized Cambridge Neuropsychological Test Automated Battery (CANTAB) to evaluate executive functioning deficits in children with ADHD. Method: Participants were unmedicated children and adolescents with ( n = 107) and without ( n = 45) Diagnostic and Statistical Manual of Mental Disorders (4th ed.) ADHD. The authors administered the CANTAB Eclipse battery, which comprises specific tasks shown to be deficient in individuals with ADHD. Results: With the exception of the affective go/no-go total omissions, ADHD participants were significantly more impaired on all other subtests of the CANTAB in comparison with controls. Effect sizes for individual CANTAB tests were largely in the medium range with the largest effect sizes seen in spatial working memory total and between errors. Conclusion: These CANTAB results are highly congruent with those reported in studies using traditional neuropsychological testing batteries, supporting the utility of the CANTAB to assess neuropsychological deficits in children with ADHD in clinical and research settings.
Neuropsychological Assessment
Neuropsychological test
Cite
Citations (53)
Neuropsychological Assessment
Neuropsychological test
Cite
Citations (15)
Background: The Cambridge Neuropsychological Test Automated Battery (CANTAB) is a computerized tool used to measure cognitive function in diverse populations and is sensitive for assessing developmental changes in children. Although CANTAB has been used in several countries, its applicability in a Mexican child population is unknown. This study examined developmental trends on CANTAB in a large sample of urban Mexico City youth and tested the hypothesis that their performance would be similar to a large US normative sample.Method: As part of a birth cohort, Early Life Exposures in Mexico to Environmental Toxicants, 826 children, ages 5–15 years, completed CANTAB. Subtests measured planning (Stockings of Cambridge; SOC), short-term memory (Delayed Matching to Sample; DMS), sustained attention (Rapid Visual Information Processing; RVP), ability to match visual stimuli (Match to Sample Visual Search; MTS), flexibility (Intra-extra Dimensional Set Shift; IED), and response inhibition (Stop Signal Task; SST). Determinants of performance on the CANTAB, including age, maternal/child IQ, and sex, were analyzed using Spearman correlation and Welch t tests. Equivalence testing compared performance with existing norms.Results: Performance improved with age on all measures. Child IQ was mildly associated with measures of memory and attention but not executive functioning, consistent with US norms. Maternal IQ was not associated with any outcomes, and males performed better on IED. Mexican norms were comparable to US norms on almost all outcomes, with the exception of a short-term visual recognition memory task (DMS).Conclusions: This study provides the largest normative data for CANTAB performance in a community sample of Mexican youth. Findings demonstrate the expected maturational effects of executive function, specifically in cognitive shifting and inhibition. Levels of executive function performance demonstrated by a Mexican sample were consistent with normative values reported in US youth. These findings, as well as expected associations with child IQ, indicate high applicability of CANTAB for Mexican youth in neurobehavioral studies.
Neuropsychological test
Cite
Citations (22)
Nagatani Fumiyo, Matsuzaki Junko, Eto Moe, Kagitani-Shimono Kuriko, Mohri Ikuko, Taniike Masako, Assessment of executive function using the Behavior Rating Inventory of Executive Function (BRIEF) and the Cambridge Neuropsychological Test Automated Battery (CANTAB) in young children with attention deficit/hyperactivity disorder, inattention type, Journai of Brain Science, 39, 5-21, 2012
Neuropsychological test
Neuropsychological Assessment
Cite
Citations (1)
Introduction: Cognitive set shifting requires flexible application of lower level processes. The Delis–Kaplan Executive Functioning System (DKEFS) Color–Word Interference Test (CWIT) is commonly used to clinically assess cognitive set shifting. An atypical pattern of performance has been observed on the CWIT; a subset of individuals perform faster, with equal or fewer errors, on the more difficult inhibition/switching than the inhibition trial. This study seeks to explore the cognitive underpinnings of this atypical pattern. It is hypothesized that atypical patterns on CWIT will be associated with better performance on underlying cognitive measures of attention, working memory, and learning when compared to typical CWIT patterns. Method: Records from 239 clinical referrals (age: M = 68.09 years, SD = 10.62; education: M = 14.87 years, SD = 2.73) seen for a neuropsychological evaluation as part of diagnostic work up in an outpatient dementia and movement disorders clinic were sampled. The standard battery of tests included measures of attention, learning, fluency, executive functioning, and working memory. Analyses of variance (ANOVAs) were conducted to compare the cognitive performance of those with typical versus atypical CWIT patterns. Results: An atypical pattern of performance was confirmed in 23% of our sample. Analyses revealed a significant group difference in acquisition of information on both nonverbal (Brief Visuospatial Memory Test–Revised, BVMT–R total recall), F(1, 213) = 16.61, p < .001, and verbal (Hopkins Verbal Learning Test–Revised, HVLT–R total recall) learning tasks, F(1, 181) = 6.43, p < .01, and semantic fluency (Animal Naming), F(1, 232) = 7.57, p = .006, with the atypical group performing better on each task. Effect sizes were larger for nonverbal (Cohen's d = 0.66) than verbal learning (Cohen's d = 0.47) and semantic fluency (Cohen's d = 0.43). Conclusions: Individuals demonstrating an atypical pattern of performance on the CWIT inhibition/switching trial also demonstrated relative strengths in semantic fluency and learning.
Cite
Citations (8)
Objective: Neurocognitive impairments have been documented in adolescents with early-onset schizophrenia (EOS). There is still inconsistency regarding an average profile, which could be due to the fact that each study uses different tests. The purpose of this study was to examine whether the "Measurement and Treatment Research to Improve Cognition in Schizophrenia" (MATRICS) battery is useful in detecting differences between the patient group and the healthy controls, and to describe the neuropsychological pattern in the EOS group. Method: Neuropsychological functioning was examined in 31 adolescents with schizophrenia spectrum disorders and 67 healthy controls, using the MATRICS battery. Results: There were significant differences between the patients and the controls on every domain except for social cognition. Patients showed a generalized neurocognitive deficit of 0.8–1.8 SDs compared with controls, with verbal learning, working memory, and visual learning being the most affected areas. Conclusions: The MATRICS battery is sensitive in detecting differences between patients and controls in the adolescent population. However, we question the use of Mayer-Salovey-Caruso Emotional Intelligence Test in this age group. Results document a significant generalized deficit in adolescents with EOS.
Neurocognitive
Neuropsychological test
Cite
Citations (113)
The Cambridge Neuropsychological Testing Automated Battery (CANTAB) is useful for the evaluation of frontal and temporal lobe dysfunction in adults with acquired lesions. The primary measures of frontal lobe function within the CANTAB battery task are spatial working memory, a self-guided search task; the Tower of London, a test of planning and behavioral inhibition; and the intradimensional/extradimensional set-shifting task, which measures the ability to shift cognitive response sets both within and across categories. CANTAB measures temporal lobe recognition memory functions through delayed-match-to-sample (DMTS) recognition memory tasks. Three other CANTAB tasks such as motor screening task, spatial span task and pattern recognition are treated as controls for the frontal lobe-mediated behavioral functions that are of primary interest. This chapter talks about the clinical validation of CANTAB in children with neurologic disorders and strategies for validation of CANTAB in childhood assessment.
Frontal lobe
Cite
Citations (21)
Background and Aim: Schizophrenia is a severe psychiatric disorder and characterized by impairments in a wide range of cognitive domains. Allen Cognitive Level Screen has been used extensively by occupational therapists as a quick screening tool to derive a view of cognitive function in people with psychiatric disabilities . Cambridge Neuropsychological Test Automated Battery (CANTAB) is a computerized neuropsychological assessment battery which is commonly used to assess an executive functioning. The purpose of this study was to examine the relationship between two measures of executive function used by different disciplines (Allen cognitive level test and CANTAB) when assessing persons with schizophrenia. Materials and Methods : In this cross-sectional study, the relation between Allen cognitive level test`s outcome and subtests of CANTAB (SWM, SSP & IED( were investigated in 30 patients with chronic schizophrenia (Mean age= 39 , man=80%,woman=20%). Allen cognitive level test was used to measure cognitive level and Spatial Span (SSP) to measure working memory capacity, Spatial Working Memory (SWM) to evaluate working memory and its strategy of usage and Intra/Extra dimensional Set Shift (IED) to assess attentional set shifting. All the data was analyzed by SPSS-16. Results: No Significant correlation was found between cognition levels of Allen test and SWM subtest (r S = -0/046; P=0/811), SSP (r S =0/009; P= -0/024) and IED (r S = -0/074; P=0/699). Conclusion: The findings of this study suggest that although patients with schizophrenia might have problems in cognitive component, they may show less problem in performing goal directed activities. In addition, the approaches of evaluation based on which the tests have been planned should be considered for investigating the correlation between two tests. It seems that the results of a top-down approach may be different from those of a bottom-up approach. Key word: Schizophrenia, Allen cognitive level test, CANTAB, executive functions
Neuropsychological test
Cognitive test
Cite
Citations (0)
Over the last decade, the Cambridge Neuropsychological Test Automated Battery (CANTAB), which comprises visuo-spatial tasks, has been utilized in cognitive studies of schizophrenia. A clear approach concerning the usage of CANTAB for the appraisal of neurocognitive dysfunction in schizophrenia is currently lacking.In this paper, we have first reviewed the overall applications of CANTAB and then evaluated methodological strengths and weaknesses of CANTAB as a neurocognitive battery for schizophrenia. We carried out a systematic search and assessment of studies where CANTAB was utilized to measure cognitive function in schizophrenia. We have also attempted to quantify the available data and perform a meta-analysis, but this approach turned out to be still premature.CANTAB has enabled researchers to highlight significant deficits affecting broad cognitive domains in schizophrenia, such as working memory, decision-making, attention, executive functions and visual memory. So far, the most consistent deficit observed with CANTAB testing has been attentional set-shifting, suggestive of fronto-striatal dysfunctions. In addition, preliminary evidence points towards the potential use of CANTAB to identify cognitive predictors of psychosocial functioning, to describe the relationships between symptoms and cognition, and to measure the impact of pharmacological agents on cognitive functioning.CANTAB has been used successfully to highlight the range of visuo-spatial cognitive deficits in schizophrenia, producing similar results to those obtained with some traditional neuropsychological tests. Further studies validating the use of CANTAB following the standard set by Measurement And Treatment Research to Improve Cognition in Schizophrenia (MATRICS) are warranted.
Neurocognitive
Cite
Citations (165)
Neurocognitive
Neuropsychological test
Trail Making Test
Memory span
Cite
Citations (100)