logo
    By using the HF—HCl—HNO3 system with high-pressure closed digestion,which can effectively dissolved cobalt-rich crust samples,fifty major and minor elements in cobalt-rich crusts can be determined by means of inductively coupled plasma Optical Emission spectrometry(ICP-OES)and inductively coupled plasma mass spectrometry(ICP-MS).The detection limit of this method is 2~40μg·g-1 by using ICP-OES and 6~80ng·g-1 by using ICP-MS.The validation of the method with cobalt-rich crust references GBW07337,GBW07338and GBW07339shows that both the relative standard deviation(RSD)and the relative error(RE)are less than 5%.Applying to the determination of cobalt-rich crust samples collected from the China Pacific Area,the precision(RSD,n=6)can be less than 5%and the recoveries are 90.0%~108%.Thus,this method can be applicable to the analysis of a large number of cobalt-rich crust samples.
    Citations (1)
    Multifunctional nanoparticles with superior imaging properties and therapeutic effects have been extensively developed for the nanomedicine. However, tumor-intrinsic barriers and tumor heterogeneity have resulted in low in vivo therapeutic efficacy. The poor in vivo targeting efficiency in passive and active targeting of nanotherapeutics along with the toxicity of nanoparticles has been a major problem in nanomedicine. Recently, image-guided nanomedicine, which can deliver nanoparticles locally using non-invasive imaging and interventional oncology techniques, has been paid attention as a new opportunity of nanomedicine. This short review will discuss the existing challenges in nanomedicine and describe the prospects for future image-guided nanomedicine.
    Cancer Imaging
    Citations (30)
    A method for The determination of Al2O3,and 5 elements Al.As.Mn.Hg.Pb.Cd in poly aluminium chloride by inductively coupled plasma mass spectrometer(ICP-MS)has been established. The contents of Al2O3 and These 5 elements in poly aluminium chloride could be simultaneously determined by ICB-MS.
    Aluminium chloride
    Citations (0)
    Nanomedicine is emerging as effective therapeutic strategy for cancer therapy. In addition, cancer nanomedicine is at the interface of several diverse fields and this, taken together with the complexities of nanomedicine and cancer, requires a multidisciplinary effort to advance the understanding and development of cancer-specific nanomedicine in order to meet the current challenges in translating nanomedicine into the clinic. In article number 1700432 Vimalkumar Balasubramanian, Hélder A. Santos, and co-workers review nanomedicine for cancer therapy.
    Cancer Therapy
    Citations (7)
    Nanomedicine aims to increase the effectiveness of therapeutic and diagnostic agents by exploiting unique properties that arise when operating at the nanoscale. Despite the recent growth of the field, nanomedicine has only managed modest improvements over conventional molecular drugs and imaging probes. To increase the efficacy of nanomedicine requires understanding fundamental processes that govern the ability of nanoparticles to locate and remain at diseased sites within the body. These processes include a nanoparticle's interactions with cells and proteins, margination in blood vessels, permeation into diseased tissues, and diffusive ability to reach all diseased cells within the tissue. Each of these processes is governed by phenomena commonly studied within fields of the physical sciences. By employing knowledge of colloidal interactions, fluid dynamics, kinetics, statistical mechanics, and thermodynamics, researchers can rationally design nanoparticles to overcome previous limitations of nanomedicine. This review will highlight recent and exemplary studies that present valuable insights into the physical phenomena of nanomedicine and present improved next-generation nanoparticle designs by applying these insights.
    Citations (46)
    Ocular Nanomedicine In article number 2003699, Zhimin Tang, Xianqun Fan, Yu Chen, and Ping Gu comprehensively overview the distinctive functional ocular nanomedicine as potential alternatives for multipurpose ocular applications. By affording insight into challenges encountered by ocular nanomedicine and further highlighting the direction of future studies, this review provides an incentive for enriching ocular nanomedicine-based fundamental research and future clinical translation.
    Citations (0)
    Nanomedicine, which is defined as application of nanoparticles in medicine, has offered new hopes for overcoming the drawbacks appeared in traditional chemotherapy. The size of nanomedicine normally in the range from 1 to 200 nm endows its potential applications in cancer therapy. But in clinics, there is still a gap between the in vitro physicochemical properties and the cellular level performance.The physicochemical properties include size, shape, surface chemistry, surface topology, and surface properties strongly affect nanomedicine inter-/intra-cellular efficiency. Herein, this article reviews effects of physicochemical properties of nanomedicine on the cellular endocytosis and intracellular route. And strategies of nanomedicine optimization are also discussed from different perspectives.On the one hand, not as that of the traditional small molecular agents, the cellular endocytosis pathway and efficiency of nanomedicine is related to its size, structure and surface properties. On the other hand, the intracellular conditions also affect the intracellular route of nanomedicine.Nanomedicine of different scale size is internalized through different pathways. While different sensitivities to intracellular conditions determined by physicochemical properties of nanomedicine will lead to different cellular consumption. So, both the properties of nanomedicine and the intracellular conditions play important roles in cellular metabolism. Consequently, nanocarriers finely engineered as the above principles can provide practical solution to the problems appeared in cellular level for promoting traditional cancer therapy.
    Nanotechnology presently has many uses in practically every one of the fields. The introduction of nanomedicine has benefitted many research areas in pharmaceutical industries. The usage of nanoparticles in drugs has shown great results that the other drugs did not. In the development of novel medicine, nanotechnology is playing an important role. It is because few medications cannot be used due to complications such as its toxicity, this can be replaced by a nanomedicine. The surface- to-volume ratio of nanomedicine with nanoparticles is greater (aspect ratio). Nanomedicine has shown its effectiveness in both diagnostics and therapeutics. In this review paper, the clinical needs of nanomedicine, drug delivery through nanomedicine has been discussed. Regenerative medicines, current era of nanomedicine, nano surgery has also been explained. Few of the applications of nanomedicine is mentioned.
    Citations (0)