Effect of prostaglandin E1 on renin and aldosterone in hypertensive patients.
Manabu YoshimuraHakuo TakahashiRyosaku TakashinaYoshihiro KajitaTadayoshi MiyazakiTakashi HachiyaHamao IjichiYukio Ochi
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Abstract:
The effect of prostaglandin E1 (PGE1) on plasma renin activity (PRA) and plasma aldosterone concentration (PAC) was studied in the hypertensive subjects treated with or without 75 mg indomethacin or 60 mg propranolol for a week. Subsequent to the treatment with indomethacin for a week, PRA and PAC levels were decreased as compared to the control, without changes in the blood pressure and heart rate. During the infusion of PGE1, the blood pressure was decreased and the pulse rate was increased. PRA and PAC levels were also elevated. These changes of parameters were not different between the control and the indomethacin-treated subjects. PRA and PAC were suppressed after the treatment with propranolol. With the infusion of PGE1, the level of PRA was not significantly elevated, while, PAC was significantly increased by the infusion of 100 ng/Kg/min of PGE1. During the infusion of PGE1, the blood pressure was decreased while the pulse rate was increased in the subjects treated with propranolol. However, the elevation of the pulse rate was less remarkable than the control. These data indicate that PGE1 have important roles in the regulation of the release of renin and aldosterone. These findings also suggest that PGE1 may act to stimulate the secretion of aldosterone in man.Keywords:
Plasma renin activity
Prostaglandin E1
Plasma renin activity
Reserpine
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bjective To investigate changes of plasma
renin activity (PRA) and aldosterone (ALD) level during 21 d -6headdown bedrest (HDT) with and
without cuffs. Methods The -6 head down bedrest 21 d was used to simulate weightlessness.
Twelve volunteers were divided into 2 groups, control group and cuffs group. In cuffs group,
cuffs on the upper parts of thighs and arms were inflated 12 h/d during 110 d,1821 d of bedrest.
No countermeasures were used in control group. Samples of plasma were taken before and
during HDT. Plasma renin activity and aldosterone were measured by radioimmunoassay.
Results PRA levels were elevated and the peak values revealed at D4, D10 respectively in
control and cuffs groups, and then declined to the preHDT level by the end of 21 d HDT in both
groups. In control group, plasma aldosterone level decreased at D2, and then increased at D4,
D10, D21.No significant difference was observed between two groups. Conclusions HDT
induces the initial hormonal response with a decrease in plasma aldosterone. The long term
effects of HDT are linked to increase of plasma renin activity and aldosterone. The change of
plasma aldosterone can be alleviated by using cuffs during HDT.
Plasma renin activity
Plasma levels
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Plasma renin activity
Circulation (fluid dynamics)
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Plasma renin activity
Essential hypertension
Hyperaldosteronism
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Plasma renin activity
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1. In patients with mild or moderate essential hypertension, oral propranolol, given in incremental doses, produced a moderate but significant lowering of blood pressure which was correlated with the concentration of propranolol in plasma. 2. Propranolol also reduced plasma renin activity (PRA) in the supine posture, on standing and after intravenous frusemide. However, 'supine' and 'frusemide' PRA values were markedly reduced at a plasma concentration of propranolol that had little effect on blood pressure. 3. On administration of propranolol there was little correlation between blood pressure decrease and PRA suppression, and even less between pretreatment PRA values and hypotensive response. 4. It is concluded that in patients with mild and moderate hypertension and low or normal plasma renin activity, suppression of PRA is not an important determinant of the hypotensive response to propranolol.
Plasma renin activity
Supine position
Essential hypertension
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The plasma half-life of propranolol after intramuscular injection is 100 min in the New Zealand female rabbit. After the administration of a single dose of propranolol. there is a lowering of plasma renin activity (PRA) and an inverse correlation between PRA and plasma propranolol. It appears that the effect of propranolol on PRA is related to the plasma level of the drug which directly relates to the time of the last administration of the drug.
Plasma renin activity
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1. Stepwise increases of oral doses of propranolol produced both a significant lowering of blood pressure and suppression of plasma renin activity in sixteen patients with mild or moderate normal-renin essential hypertension. 2. The hypotensive and the renin-suppressive actions of propranolol were differently related to plasma propranolol concentrations. At the lowest propranolol concentrations (15–40 nmol/l), there was almost no decrease in blood pressure whereas plasma renin activity and responsiveness to renin-releasing stimuli (standing, intravenous frusemide) were already strongly depressed (greater than 50%). Therefore in a large number of normal-renin hypertensive patients under small doses of propranolol, the renin-suppressive action of the drug can be dissociated from the hypotensive effect. Dissociation of the two effects, though in the opposite way, was also observed in three of four low-renin hypertensive patients, whose blood pressure was decreased by propranolol without further reduction of the already suppressed plasma renin activity. 3. It is concluded that in patients with mild and moderate hypertension and low or normal plasma renin activity, the hypotensive effect of propranolol cannot be attributed to suppression of renin activity. These conclusions do not necessarily apply to high-renin hypertensive patients.
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Essential hypertension
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