BDNF Is a Negative Modulator of Morphine Action
Ja Wook KooMichelle S. Mazei‐RobisonDipesh ChaudhuryBarbara JuarezQuincey LaPlantDeveroux FergusonJian FengHaoSheng SunKimberly N. ScobieDiane Damez-WernoMarshall CrumillerYoshinori N. OhnishiYoko OhnishiEzekiell MouzonDavid DietzMary Kay LoboRachael L. NeveScott J. RussoMing‐Hu HanEric J. Nestler
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Regulating Opioid Responses Different drugs of abuse are thought to highjack similar reward systems in the brain using common mechanisms. However, Koo et al. (p. 124 ) now observe that some of the neural mechanisms that regulate opiate reward can be both different and even opposite to those that regulate reward by stimulant drugs. While knockdown of brain-derived neurotrophic factor (BDNF) in the ventral tegmental area in mice antagonized the response to cocaine, the same manipulation strengthened the potential of opiates to increase dopamine neuron excitability. Optogenetic stimulation of dopaminergic terminals in the nucleus accumbens could counteract the effects of BDNF on morphine reward blockade.Keywords:
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There are some important components in the reward system include insular, prefrontal and orbitofrontal cortexes, ventral pallidum, nucleus accumbense, amygdala and ventral tegmental area. The origin of the dopaminergic reward system is the ventral tegmental area which is the dopaminergic neurons location and can activate the ventral striatum by sending the dopaminergic neurons axons to that.
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