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    Über experimentell erzeugtes Pigment in Vitiligo
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    Vitiligo
    Pigmentation disorder
    Objective To investigate the early diagnosis of vitiligo and its differential diagnosis from other depigmentated diseases using polarized light dermoscopy(PD)imaging analysis.Methods Patients with localized depigmented macules were enrolled into this study.PD was used to observe the micromorphology,feature and color of skin lesions.Histopathology was performed to confirm the diagnosis of all cases except for those of pityriasis versicolor which were confirmed by clinical and laboratory examination.Results Of the 176 patients.97 were diagnosed as vitiligo.Residual perifollicular pigmentation Was observed in 91.94%(57/62)of patients with progressing vitiligo and 62.86%(22/35)of those with stable vitiligo,with significant difference between the two groups of patients(P<0.05).However.residual perifollicular pigmentation was absent in the 79 non-vitiligo depigrnented cases.The presence of telangiectasia,early reservoirs of pigmentation and perilesional hyperpigmentation were related to the stage of vitiligo and treatment history of patients.Conclusions PD,which efficiently eliminates the interference of reflected light on skin lesions of vililigo,is an imaging technique that allows for the visualization of minor structures and features of the skin lesions that are indiscernible to naked eyes.In a nutshell,the application of PD has offered references to the early diagnosis of vitiligo and its differential diagnosis from other depigmentation diseases. Key words: Vitiligo; Dermoscopy,polarized light; Depigmentation macule; Residual perifollicular pigmentation
    Vitiligo
    Depigmentation
    Pigmentation disorder
    Pityriasis
    Hypopigmentation
    Histopathology
    Recently, a patient presented to us with skin that had areas of normal pigmentation, hyperpigmentation, and depigmentation. Workup eventually showed him to have simultaneously active lesions of a depigmenting disorder, vitiligo, and a hyperpigmenting disorder, erythema dyschromicum perstans.
    Vitiligo
    Depigmentation
    Erythema
    Pigmentation disorder
    Hypopigmentation
    Background: Long-term treatment with low to moderate dosages of the antimetabolite and antifolate medication methotrexate (MTX) has been shown to be effective, safe, and well-tolerated for a wide range of autoimmune diseases.As a result, methotrexate may be used to treat vitiligo and other autoimmune disorders.The hepatotoxic and hematologic side effects of the drug's topical formulations, which were developed for the treatment of localized lesions, were deemed to be clinically insignificant.Objective: This review article aimed to assess the possible role of topical methotrexate in the management of vitiligo.Methods: Methotrexate, and the vitiligo were all looked for in PubMed, Google scholar, and Science direct.References from relevant literature were also evaluated by the authors, but only the most recent or complete studies from January 2005 to May 2021 were included.Due to the lack of sources for translation, documents in languages other than English were ruled out.Papers that did not fall under the purview of major scientific investigations, such as unpublished manuscripts, oral presentations, conference abstracts, and dissertations, were omitted.Conclusion: Topical methotrexate use could be an effective and safe treatment modality of vitiligo.
    Vitiligo
    Citations (1)
    Vitiligo is an acquired pigmentary disorder, clinically characterized by depigmented macules caused by destruction of melanocytes in the affected skin. Half of all patients develop the disease in childhood and adolescence before the age of 20 years, making vitiligo an important skin disease of childhood. There are numerous studies in the literature that suggest the efficacy of topical tacrolimus in vitiligo, without serious adverse effects. We describe a case of vitiligo in a pediatric patient who developed hyperpigmentation in the periorbital lesions of vitiligo with the use of topical tacrolimus. To the best of our knowledge, this is only the second such reported occurrence in a patient with vitiligo.
    Vitiligo
    Pigmentation disorder
    Citations (6)
    Individuals with vitiligo have a low risk of developing non-melanoma skin cancer [1, 2]. Previous studies have reported imiquimod-induced vitiligo-like depigmentation in patients with genital warts and superficial basal cell carcinomas [3, 4]. Here, we report a case of persistent vitiligo-like depigmentation caused by topical application of imiquimod 5% cream for multiple solar keratosis in a patient with non-segmental vitiligo.A 67-year-old man was referred to us in July 2010 with an 11-year history [...]
    Vitiligo
    Depigmentation
    Imiquimod
    Pigmentation disorder
    Keratosis
    Actinic keratosis
    Citations (5)
    Depigmentation
    Vitiligo
    Hypopigmentation
    Pigmentation disorder
    The progression of vitiligo and postinflammatory hyperpigmentation simultaneously in a patient with AIDS led to the appearance of a blue color on much of the patient's skin. The blue coloration subsequently resolved with follicular repigmentation typical of resolving vitiligo. We believe this is the first reported case of "blue vitiligo."
    Vitiligo
    Pigmentation disorder
    © 2009 The Authors. doi: 10.2340/00015555-581 Journal Compilation © 2009 Acta Dermato-Venereologica. ISSN 0001-5555 Sir, Vitiligo is a disease caused by loss of melanocytes. It can be classified as segmental, acrofacial, generalized and universal, or by pattern of involvement, such as focal, mixed, and mucosal types. In generalized and universal vitiligo, the entire body surface may be depigmented, leaving only a few normally pigmented macules and patches in some areas (1). Therefore it is sometimes difficult to diagnose generalized vitiligo if the patient does not show any normally pigmented macules. We report here a rare case of repigmentation after strong sun exposure in a patient diagnosed with vitiligo universalis.
    Vitiligo
    Pigmentation disorder
    Citations (0)