Red blood cell distribution width is a potential index to assess the disease activity of systemic lupus erythematosus
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Erythrocyte sedimentation rate
Erythrocyte sedimentation rate
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Aim: To determine whether red cell distribution width could be used for the assessment of disease activity in patients with infl ammatory bowel disease. Materials and methods: A total of 165 patients with infl ammatory bowel disease (105 ulcerative colitis; 60 Crohn’s disease) and 43 healthy blood donors were included in this retrospective study in a tertiary care setting. Th e medical records of the patients were reviewed to note clinical activity indices, red cell distribution width, serum C reactive protein, erythrocyte sedimentation rates, leukocyte, and platelet counts. Results: Red cell distribution width, serum C reactive protein, erythrocyte sedimentation rate, platelet count, and the proportion of individuals with increased red cell distribution width were all signifi cantly elevated in the patients compared to the controls (P < 0.05). Red cell distribution width and the proportion of patients having elevated red cell distribution width were higher in patients with Crohn’s disease compared with ulcerative colitis (P < 0.05). Red cell distribution width was signifi cantly correlated with erythrocyte sedimentation rate, endoscopic activity index (in ulcerative colitis), and platelet count (P < 0.05). For a red cell distribution width cut-off of 14.45 sensitivity for diff erentiation of Crohn’s disease from ulcerative colitis was 70% and specifi city was 56%. Conclusion: Red cell distribution width, as a cost-eff ective tool, could be an additional parameter to assess disease activity in infl ammatory bowel disease and an adjunctive marker in the diff erentiation between ulcerative colitis and Crohn’s disease.
Erythrocyte sedimentation rate
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Erythrocyte sedimentation rate
White blood cell
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Objective To investigate the clinical application value of C-reactive protein(CRP)and erythrocyte sedimentation rate(ESR)in old pulmonary infection patients.Methods 500 old pulmonary infection patients were investigated in the study.CRP，ESR and white blood count(WBC)were measured on the 1St，3rd，5th，7th，14th day's morning.And clinical pulmonary infection score(CPIS)was measured on the 1st day of hospital entrance.Results①After therapy，all indexes descended obviously(P ESR.Conclusions Both CRP and ESR can be used to value the diagnosis and therapy in old pulmonary infection patients.CRP is helpful to identify the early infection and judge the severity of infection.And it can also reflect the therapeutic effect rapidly.CRP is a good index that has an obvious advantage than ESR and WBC.
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C-reactive protein; Erythrocyte sedimentation rate; Old patients; Pulmonary infection
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Red cell distribution width (RDW) is a measure of the variation in mean corpuscular volume that reflects the degree of anisocytosis on the peripheral blood smear. RDW value variation has been implicated in several disorders including chronic inflammatory processes and cardiovascular (CV) diseases. In the present work, our objective was to study the relationship that RDW has with the characteristics of the disease in patients with rheumatoid arthritis (RA), focusing on CV risk factors and subclinical atherosclerosis. A cross-sectional study was conducted that included 430 patients with RA and 208 controls matched by sex and age. Complete blood count, including RDW, was assessed. Multivariable analysis was performed to analyze the relationship of RDW with RA disease characteristics, subclinical carotid atherosclerosis, and traditional CV factors, including a comprehensive profile of lipid molecules and insulin resistance and beta cell function indices. After multivariable adjustment, the RDW was significantly higher in RA patients compared with controls (beta coefficient 1.0 [95% confidence interval 0.2 to 1.8] %, p = 0.020). Furthermore, although the erythrocyte sedimentation rate showed a positive and significant relationship with RDW, this association was not found with C-reactive protein and interleukin-6. A positive and independent relationship was observed between DAS28-ESR disease activity score and RDW. However, no association was found between the RDW and other disease activity scores that do not include erythrocyte sedimentation rate in their formula. The SCORE2 CV risk algorithm was positively and significantly associated with higher RDW values. Likewise, a negative relationship was found between RDW with total cholesterol and low-density lipoprotein cholesterol, and a positive relationship was found between RDW and insulin resistance indices. In conclusion, RDW values are higher in RA patients compared to matched controls. Although the relationship of RDW with disease activity was not consistent, RDW shows associations with subclinical CV disease risk factors, including dyslipidemia and insulin resistance, and with the SCORE2 CV disease-risk prediction algorithm.
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Subclinical infection
Anisocytosis
Complete blood count
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Recently, it has been suggested an association between red cell distribution width (RDW) and Crohn's disease activity index (CDAI), but its use is not yet performed in daily clinical practice.To determine whether RDW can be used as a marker of Crohn's disease (CD) activity.This was a cross-sectional study including patients with CD, observed consecutively in an outpatient setting between January 1st and September 30th 2013. Blood cell indices, erythrocyte sedimentation rate (ESR), and C-reactive protein were measured. CD activity was determined by CDAI (active disease if CDAI ≥ 150). Associations were analyzed using logistic regression (SPSS version 20).119 patients (56% female) were included in the study with a mean age of 47 years (SD 15.2). Twenty patients (17%) had active disease. The median RDW was 14.0 (13-15). There was an association between RDW and disease activity (p = 0.044). After adjustment for age and gender, this association remained consistent (OR 1.20, 95% CI 1.03-1.39, p = 0.016). It was also found that the association between RDW and disease activity was independent of hemoglobin and ESR (OR 1.36, 95% CI 1.08-1.72, p = 0.01) and of biologic therapy (OR 1.19, 95% CI 1.03-1.37, p = 0.017). A RDW cutoff of 16% had a specificity and negative predictive value for CDAI ≥ 150 of 88% and 86%, respectively.In this study, RDW proved to be an independent and relatively specific marker of CD activity. These results may contribute to the implementation of this simple parameter, in clinical practice, aiming to help therapeutic decisions.Recentemente, tem vindo a ser sugerida uma associação entre o valor de RDW e a atividade da doença de Crohn (DC), mas a sua utilização não está ainda implementada na prática clínica diária.Determinar se o RDW pode ser utilizado como marcador de atividade da DC.Estudo transversal, em doentes com DC, observados consecutivamente em consulta de Doença Inflamatória Intestinal, entre 1 de janeiro e 30 de setembro de 2013. Analisaram-se índices do hemograma, proteína C reativa e velocidade de sedimentação. A gravidade da doença foi avaliada pelo Crohn's disease activity index (doença ativa se CDAI≥150). As associações foram estudadas usando a regressão logística (SPSS Statistics V20).Incluídos 119 doentes (56% do sexo feminino), com idade média de 47 anos (DP 15,2 anos). Vinte doentes (17%) tinham doença ativa. O valor do RDW mediano foi 14,0% (13-15). Verificou-se uma associação entre RDW e atividade da doença (p = 0,044). Após ajuste para a idade e o sexo, esta associação manteve-se consistente (OR 1,20; 95% CI 1,03-1,39; p = 0,016). Verificou-se ainda que a associação do valor do RDW com a atividade da doença foi independente do valor da hemoglobina e da velocidade de sedimentação (OR 1,36; 95% CI 1,08-1,72; p = 0,01) e da terapêutica biológica (OR 1,19; 95% CI 1,03-1,37; p = 0,017). Para um valor de corte de RDW de 16%, a especificidade e o valor preditivo negativo de CDAI≥ 150 foram de 88% e 86%, respetivamente.Neste estudo, o valor do RDW demonstrou ser um marcador independente e relativamente específico da atividade da doença de Crohn. Estes resultados poderão contribuir para a aplicação deste parâmetro simples, na prática clinica diária, visando auxiliar decisões terapêuticas.
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Serum C reactive protein (CRP) levels and erythrocyte sedimentation rates (ESR) were measured in 56 patients with rheumatoid arthritis. Radiographical damage, based on a count of erosions, was significantly more likely to occur when serum CRP and ESR were persistently raised, irrespective of the presence or absence of rheumatoid factor. Measurements of both CRP and ESR were more helpful than either alone, but CRP was probably the more informative. Serial measurements of CRP and ESR provide a reliable means of discriminating between drugs that provide symptomatic relief only and those with a more profound effect in rheumatoid arthritis.
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Objective To investigate the clinical value of high sensitive C-reactive protein(hs-CRP)in septic knee.Methods The results of hs-CRP,erythrocyte sedimentation rate (ESR),white blood cell count(WBC),neutrophile granulocyte percentage (NGP) of 46 septic knee cases were compared and analyzed retrospectively.Results The sensitivity of hs-CRP was higher than WBC and NGP,not higher than ESR.The same as other examinations,the levels of hs-CRP had not significant difference between the patients with different degree of synovial infection.None of the four examinations showed significant difference when symptoms relieve.There was weak positive linear correlation between hs-CRP and ESR.Conclusion High sensitive C-reactive protein doesn’t show higher clinical value in septic knee.
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White blood cell
Clinical Significance
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Background : Myocardial Infarction is the cause of morbidity and mortality in Sudan. This study described altered Red Cell Distribution Width –SD (RDW-SD), Red Cell Distribution Width –CV (RDW-CV), C-reactive protein (CRP) and Erythrocyte sedimentation rate (ESR) in patients with Myocardial Infarction compared with other heart diseases and healthy control. Methods : Red Cell Distribution Width –SD (RDW-SD), Red Cell Distribution Width –CV (RDW-CV) , C-reactive protein (CRP) and Erythrocyte sedimentation rate (ESR) in (30) patients with Myocardial Infarction, (30) patients with heart diseases other than MI and (30) persons were determined as healthy control. Test significance was done to the three groups. Result : The results of this study showed high level of ESR, CRP, RDW-SD and RDW-CV in patients with MI when compared with healthy group with t.test (P.V: 0.000) Patients with other heart diseases also showed high ESR, CRP, RDW-SD and RDW-CV when compared with healthy group with t.test (P.V:0.000).But when comparison was done b\w MI and other heart diseases ,results showed MI has more effect on those tests than other heart diseases. But RDW-CV was not significantly different b\w the two groups (P.V:0.133) (Significant less than 0.05 or = 0.05) Conclusion: Myocardial infarction is associated with increase in RDW-SD, RDW-CV, CRP and ESR. And may be used as probable indicators for Myocardial Infarction.
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Anisocytosis
Erythrocyte sedimentation rate
White blood cell
Mean platelet volume
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