Superficial Granulomatous Pyoderma
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Pyoderma
Neutrophilic Dermatosis
Pyoderma
Refractory (planetary science)
Ciclosporin
Pathogenesis
Neutrophilic Dermatosis
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Neutrophilic dermatoses include a spectrum of disorders with similar histologic appearance and pathologic processes. Clinically, however, they have different physical manifestations and associations. This group includes two diseases for which dermatologists are commonly consulted in the hospital, namely pyoderma gangrenosum and acute febrile neutrophilic dermatosis, or Sweet's syndrome. Evaluation is challenging, and many therapeutic approaches have been described for both. The previously reported diagnostic criteria, physical descriptions, differential diagnosis, workup, and treatment options are reviewed. A practical approach to pyoderma gangrenosum and Sweet's syndrome for the provider is described.
Neutrophilic Dermatosis
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Pyoderma
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Effective treatment of the phagedenic ulcers of pyoderma gangrenosum has been difficult, and numerous therapeutic measures have been reported. Four recently reported cases have healed promptly with hyperbaric oxygen (HBO) therapy.1-3Our patient had extensive pyoderma gangrenosum that failed to heal despite treatment with sulfones and corticosteroids.
Report of a Case
A 23-year-old woman came to the University of Texas Medical Branch with a four-year history of persistent, pustular ulcerations that had been previously diagnosed as pyoderma gangrenosum. She had received the standard treatments for pyoderma gangrenosum, which included 60 mg/day of prednisone on two different occasions and sulfone therapy for the past three months, without resolution of the ulcerations. Examination disclosed a 35 × 15-cm purulent ulceration on the lower portion of the right leg and a 9 × 15-cm ulceration on the lower portion of the left leg (Fig 1). New erythematous papulopustules continued to develop aroundPyoderma
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Pyoderma gangrenosum (PG) is a non-infectious disease characterized by necrotizing, ulcerative, and painful skin. The incidence of PG is approximately 3—10 cases per million people per year. Pyoderma gangrenosum is rarely observed in children, which accounts for less than 4%, but it primarily affects adults between the ages of 25 and 54 years old without gender preference. Here, we present a case report of a 16-month-old toddler diagnosed with pyoderma gangrenous with splenic involvement. The young age of the patient and extracutaneous manifestation are of high interest.
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Superficial granulomatous pyoderma is a rare entity thought to be a variant of pyoderma gangrenosum and is often mistaken for classic pyoderma gangrenosum. Superficial granulomatous pyoderma has mainly been described in adults. We describe a case of Superficial granulomatous pyoderma in an 11-year-old girl and present a review of the literature. Superficial granulomatous pyoderma maintains clinical and histopathologic characteristics distinct from classic pyoderma gangrenosum and has a more favorable prognosis. It is often responsive to conservative treatment.
Pyoderma
Neutrophilic Dermatosis
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Pyoderma gangrenosum Is an ulcerating skin condition associated with Inflammatory bowel disease and other diseases. During an 18-month period beginning In the fall of 1991, seven patients were followed up for pyoderma gangrenosum. Three of these cases, with assessment and treatment plans, are presented. A discussion of treatment principles for managing pyoderma gangrenosum follows.
Pyoderma
Neutrophilic Dermatosis
Inflammatory Bowel Diseases
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We describe a patient with a highly unusual appearance of pyoderma gangrenosum. The pyoderma was located on the auricular region and preceded other manifestations of inflammatory bowel disease by 11 years. There was no correlation between the course of the pyoderma and the clinical activity of the associated bowel disease. Mycotic superinfections masked and delayed the diagnosis in our patient for several years. Only when typical pyoderma gangrenosum lesions developed on the legs at the site of trauma and responded dramatically to systemic corticosteroids was the correct diagnosis established. Pyoderma gangrenosum with secondary fungal infection was thus distinguished from deep ulcerated skin fungal infection simulating pyoderma.
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Pyoderma
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Abstract A 71‐year‐old Japanese female with gigantic pyoderma gangrenosum is reported. The pyoderma lesions had been treated as an infectious condition for seventeen months and had extended to enormously large areas. The nature of the chronic type of pyoderma gangrenosum may need to be stressed, even for dermatologists.
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Pyoderma gangrenosum is an inflammatory disease that has been found to be associated with many systemic illnesses. Here we describe, first time to our knowledge of pyoderma gangrenosum as well as pyostomatitis vegetans in a patient with hypogonadotropic hypogonadism. Later on inflammatory bowel disease was also detected. The pyoderma lesions appeared as multiple outbreaks which resolved totally after several combined immunosuppressive treatment. The clinical course of pyoderma gangrenosum and inflammatory bowel disease appeared independent, with no apparent overlap in inflammatory activity or response to the drugs administered.
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