Ketoprofen (‘Orudis’) in the treatment of inflammatory arthritic conditions: a multi-centre study in general practice
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SummaryAn open multi-centre study was carried out in general practice to assess the effectiveness and tolerance of ketoprofen in the treatment of 1997 patients with inflammatory arthritic conditions. Patients were treated with 100 mg ketoprofen twice daily for 4 weeks and subjective assessments were made before and after treatment of the clinical symptoms of pain and/or stiffness. The results showed that ketoprofen produced a statistically significant relief of symptoms in painful joints, regardless of whether these were thought to be affected primarily by rheumatoid or osteoarthritic processes. Joint stiffness also improved in the majority of cases. The side-effects reported related mainly to gastro-intestinal symptoms: there were no cases of overt haemorrhage and no serious adverse reactions.Keywords:
Ketoprofen
Joint pain
Clinical Practice
Osteoarthritis (OA) is a degenerative joint disease related to joint cartridge damage. Several OA risk factors are age, sex, race, genetics, obesity and metabolism disease, joint injury occupation and sports, growth disorders, and other factors. The modality generally used to reduce pain, joint tension, and fighting muscle atrophy in knee OA is completing several physiotherapies. One objective study case research by using purposive sampling and conducting an interview with knee OA patients. The T-test evaluation result of the physiotherapy influence to pain reduction in osteoarthritis found that there is before (33,5) and after (22,00) mean decrease with deviation standard before (6,704) and after (3,258) the therapy. Thus, physiotherapy influenced towards reducing pain osteoarthritis.
Joint disease
Joint pain
Knee pain
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Clinical and laboratory assessments in rheumatoid arthritis and osteoarthritis precede imaging methods in both defining diagnosis and determining response to therapy. Some assessments are similar in both diseases, e.g. measuring joint pain, the number of involved joints and functional impairment. There are also areas of difference; for example, rheumatoid arthritis is a systemic disease with immune disturbance and positive tests for rheumatoid factor and elevated acute phase markers while osteoarthritis is a more local disease with little systemic upset. In both diseases pain and progressive joint damage result in increasing disability. There is agreement on a core data set in rheumatoid arthritis which comprises: swollen joint counts, tender joint counts, pain assessment, patient's global assessment, an acute phase marker such as the ESR and a self-administered functional questionnaire. There is less agreement on the core data set in osteoarthritis, though pain and functional impairment are both important. Combined or overall indices have been used in both rheumatoid arthritis (e.g. the disease activity score) and in osteoarthritis (e.g. the Lequesne functional index), but there is no general agreement on their value. In both diseases plain radiology is useful to define diagnostic groups and follow progression in long-term studies. Mortality is increased in rheumatoid arthritis and is useful for defining the long term effects of the disease; little is known about mortality in osteoarthritis. Standardizing clinical methods is important and much work is needed in this area.
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Osteoarthritis is a disease characterized by joint pain. For this reason, non-pharmacological interventions for rheumatic exercises are needed regularly and routinely to reduce joint pain. This study aims to determine the effect of rheumatic exercise on joint pain in patients with osteoarthritis. Type of research is a pre-experimental design with a One Group Pretest – Posttest approach. The study population was patients with osteoarthritis. The sampling used is non-probability sampling with Accidental Sampling technique, the number of samples as many as 27 people. The research instrument used rheumatic gymnastics SOP and pain instrument with a numeric rating scale. Data analysis using the Wilcoxon test. The results showed that the patient's joint pain before rheumatic exercise was moderate pain average pain scale 4.70, after rheumatic exercise the joint pain experienced mild pain with average scale 3.63. The results of the statistical test showed that the p-value was 0.012 < (0.05), so the research hypothesis was accepted. The conclusion of the study showed that there was an effect of rheumatic exercise on joint pain in patients with osteoarthritis. It is hoped that health workers can apply rheumatic exercise therapy as an alternative to non-pharmacological therapy in reducing joint pain in patients with osteoarthritis.
Keywords: Rheumatic gymnastics; Joint pain; Osteoarthritis
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Purpose:The purpose of this study was to examine the degree of joint pain, limitation of daily activities, and frequency of outpatient visits. Methods: This secondary analysis study used the data from the fifth Korean National Health and Nutrition Examination Survey (KNHNES). The data about general characteristics, prevalence and treatment of osteoarthritis, limitation of activities of daily living (ADL) and frequency of outpatient visits and hospitalization in 424 osteoarthritis patients over 50 years old were derived from the database. Data were analyzed with complex samples in SPSS ver. 20.0. Results: Among people with knee joint pain, 79.3% reported they had more than 4 out of 10 points of the degree of pain. Meanwhile, 97.3% of people with hip joint pain reported that they had more than 4 out of 10 points of the degree of pain. People reporting 10 out of 10 point of pain were 21.4% of those with knee joint pain and 25% of those with hip joint pain. The mean of the degree of knee joint pain was 6.35, and the mean of the degree of hip joint pain was 6.89 out of 10 points. About 50% of people with osteoarthritis visited an outpatient clinic within the last 2 weeks, and 27% had limitation of ADL. Conclusion: It is necessary to develop an integrated intervention program to improve quality of life in patients with osteoarthritis.
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Arthritis is one of the most common chronic illnesses managed in primary care. Osteoarthritis and rheumatoid arthritis are two common types the provider must distinguish between in terms of diagnosis and treatment. Osteoarthritis, the most common form, typically occurs in people more than 60 years of age and involves cartilage destruction. Signs and symptoms are local and include cool, bony joints and arthralgia that worsens with weight bearing. Treatment includes acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs), exercise, and joint arthroplasty in severe cases. Rheumatoid arthritis is a systemic disease that results in symmetrical joint inflammation along with constitutional symptoms such as fatigue and depression. Current treatment recommendations include early use of disease modifying anti-rheumatic drugs along with NSAIDs. The key to arthritis management is early diagnosis and treatment to prevent further joint destruction and maximize functional ability.
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Osteoarthritis as the most common form of arthritis, affects predominantly middle-aged and elderly population worldwide. This chronic, degenerative, progressive and multi factorial joint disease can affect different joints in the body. One of the most commonly affected joints with osteoarthritis is the hip joint. The present study objective was “to assess the effectiveness of isometric exercises in reduction of hip pain among the osteoarthritis clients” at selected old age homes of Amritsar. Research approach was used is pre -experimental research design one group pre test and post test. The target population for the study was osteoarthritis clients. The total samples under the study were 60 osteoarthritis clients. The data was collected by using Numerical Pain Rating Scale which was designed to assess the effectiveness of isometric exercises in reduction of hip pain among the osteoarthritis clients. The results were described by using descriptive and inferential statistics. Findings of pre test revealed that 6.67 i.e 6.67% of clients have worst pain, 60 i.e 60% of clients have severe pain, 28.33 i.e 28.33% of clients have moderate pain, 3.33 i.e 3.33% of clients have mild pain and 1.67 i.e1.67% of clients have no pain. Findings related to effectiveness of isometric exercises in reduction of hip pain among the osteoarthritis clients depicts that, enhancement between the pre-test and post-test was 2.0 and obtained paired t test value was 5.6, it was highly significant at level <0.05.This shows the effectiveness of isometric exercises in reduction of hip pain. Chi-square test revealed that there was statistically significant association between post test score of osteoarthritis clients with hip pain with their demographic variables.
From the result of the study, it was concluded that isometric exercises was effective in reducing hip pain among the osteoarthritis clients.
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Objective: to reveal neurogenic mechanisms in the pathogenesis of chronic pain syndrome in rheumatoid arthritis (RA) and knee osteoarthritis (OA) in order to develop individualized pharmacotherapy. Subjects and methods . One hundred and eighty-three patients with RA and 80 with knee OA were examined. By using the neuropathic pain diagnostic questionnaire (DN4), all the patients were divided into 2 groups with and without a neuropathic pain component (NPC). Results. NPC was found in 43% of the patients with RA and it was connected with involvement of the peripheral somatosensory system. In RA, NPC was common in older patients with longer disease duration, higher X-ray stage, and severe functional insufficiency. 30% of patients with knee OA also had NPC, however the signs of nervous system involvement were absent. In OA, NPC was associated with hyperalgesia, higher pain intensity, more marked joint dysfunction on the WOMAC, and anxiety. Discussion. This investigation revealed a mixed pattern of chronic pain syndrome in patients with RA and knee OA; some patients were found to have a NPC in the presence of predominantly a nociceptive component
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Ketoprofen (Orudis) in doses of 100-200 mg daily was given to 11 patients with rheumatoid arthritis and 14 patients with osteoarthritis. Relief of pain and reduction of inflammation was 50% or more when the drug was given in appropriate doses. The degree of response in degenerative joint disease was better than that in the inflammatory arthritis. Gastrointestinal tolerance of the drug was good and only minor side effects were observed in less than 25% of the patients. The drug was discontinued in only one patient because of side effects.
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Joint disease
Joint pain
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Non-steroidal anti-inflammatory drugs (NSAIDs) have been demonstrated to have significant cardiovascular and gastrointestinal toxicity; high dose of intake and concomitant use of multiple compounds or corticosteroids are factors that increase the risk of NSAID toxicity. In this paper we described our experience on NSAIDs misuse (both prescribing and OTC formulations), particularly relevant in the setting of rheumatoid arthritis (39.5 percent of patients) and osteoarthritis (47 percent of patients). We also evaluated causes underlying NSAIDs misuse (e.g. not satisfactory pain control, other painful conditions, etc).
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Osteoarthritis (OA) is the most common form of arthritis and the most prevalent type among rheumatic diseases. Osteoarthritis is a degenerative joint disorder with minimal signs of inflammation, and it is a progressive disease whose clinical manifestations are joint structure abnormalities (visible by imaging modalities) and a symptom complex characterized by function limitation, pain, disability, and possibly with reduced quality of life. Pain is a sensation that is caused by a stimulus of harmful nature. It is the common and distressing manifestation of arthritis. Pharmacological pain remedies offer pain relief along with many unpleasant side effects. Mud pack therapy allows temporary relief from the pain but also allows the patient’s self-healing abilities to be activated along with a cheer and strength in their psychological and emotional level.
Method: A quantitative research approach with quasi experimental pre-test post-test one group design was adopted and study setting was conducted in Kalitheerthalkuppam, Puducherry. Thirty clients with knee osteoarthritis were selected with convenient sampling technique. Modified WOMAC (Western Ontario McMaster University Osteoarthritis Index) Index scale is a 20 item questionnaire with 5 points ranging score was used for assessing the knee joint pain among the study subjects in terms of pain, stiffness, and physical function.
Results: The frequency and percentage wise distribution on level of pain among clients with knee osteoarthritis. In pretest 3 (9.99%) of them had mild level of pain, 17 (56.61%) of them had moderate level of pain whereas, 10(33.3%) of them had severe level of pain. In posttest 21 (69.93%) of the client had mild level of pain and 9 (29.97%) of the patients had moderate level of pain. As on to the association with demographic variables, people with a lower duration of illness (34%), and (60%) of nonvegetarian in diet pattern and around (37%) of moderate workers in life style pattern had influence in reduction of pain and are associated with the mud therapy and shows that highly significant at p<0.01 level. Hence, mud therapy is effective in terms of pain relief and functional improvement among knee osteoarthritis clients.
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