Parainfluenza virus infections in a tropical city: clinical and epidemiological aspects
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Abstract:
Little information on the epidemiology and clinical characteristics of human parainfluenza virus (HPIV) infections, especially in children from tropical countries, has been published. The aim of this study was to determine the frequency of HPIV infections in children attended at a large hospital in Fortaleza in Northeast Brazil, and describe seasonal patterns, clinical and epidemiological characteristics of these infections. From January 2001 to December 2006, a total of 3070 nasopharyngeal aspirates collected from children were screened by indirect immunofluorescence for human parainfluenza viruses 1, 2, and 3 (HPIV-1, 2 and 3) and other respiratory viruses. Viral antigens were identified in 933 samples and HPIV in 117. The frequency of HPIV-3, HPIV-1 and HPIV-2 was of 83.76%, 11.96% and 4.27%, respectively. Only HPIV-3 showed a seasonal occurrence, with most cases observed from September to November, and with an inverse relationship to the rainy season. Most HPIV-3 infections seen in outpatients were diagnosed as upper respiratory tract infections.Keywords:
Human Parainfluenza Virus
Teaching epidemiology in and out of the classroom, J.H. Abramson teaching the reluctant student, C. du V. Florey principles of epidemiology study design and planning, A. Ahlbom data collection and processing, E. Schach preparing for statistical analysis, J. Olsen teaching statistical methods in epidemiology, D. Clayton clinical epidemiology, J.A. Baron epidemiology in health services research, R.D. Weir screening for cancer, N. Day cancer epidemiology, C.S. Muir psychiatric epidemiology, R. Fuhrer and E. Fombonne occupational epidemiology, F. Merletti and P. Comba epidemiology of coronary heart disease, P. Ducimetiere and A. Kalandidi epidemiology of ageing and diseases in the elderly, A. Hofman epidemiology of infectious diseases and the study of outbreaks, D. Reid teaching the practice of epidemiology, U. Brinkmann the epidemiology of tropical diseases, M.E. Wilson epidemiology of AIDS, D. Trichopoulos et al teaching oral and dental epidemiology, F. Scheutz and A. Sheiham pharmacoepidemiology, M.S. Porta and X. Carne teaching epidemiology in EC countries, S. Allwright and J. Pemberton application and teaching of epidemiology developments in the European region of the World Health Organization, M. Thuriaux.
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Respiratory tract
Rhinovirus
Respiratory infection
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epiweek creates epidemiological week and equivalent epidemiological year from the calendar date. It extends the week function of Stata. Each epidemiological week begins on a Sunday and ends on Saturday. And the first epidemiological week of year ends on the first Saturday of January, provided that it falls at least four or more days into the month. epiweek2 converts epidemiological week and epidemiological year to the calendar date with the starting Sunday and the ending Saturday.
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Human Parainfluenza Virus
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To better define the contribution of human parainfluenza viruses (HPIVs) to lower respiratory tract infection in adults, we tested acute- and convalescent-phase serum specimens from hospitalized adults participating in a population-based prospective study of lower respiratory tract infection during 1991–1992. We tested all available specimens from the epidemic seasons for each virus and ∼300 randomly selected specimens from the corresponding off-seasons for antibodies to HPIV-1, HPIV-2, or HPIV-3. During the respective epidemic season, HPIV-1 infection was detected in 18 (2.5%) of 721 and HPIV-3 infection in 22 (3.1%) of 705 patients with lower respiratory tract infection. Only 2 (0.2%) of 1,057 patients tested positive for HPIV-2 infection. No HPIV-1 infections and only 2 (0.7% of 281 patients tested) HPIV-3 infections were detected during the off-seasons. HPIV-1 and HPIV-3 were among the four most frequently identified infections associated with lower respiratory tract infection during their respective outbreak seasons.
Human Parainfluenza Virus
Respiratory tract
Respiratory infection
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Abstract Respiratory infections are very common in Kuwait, yet little is known about the cause of severe lower respiratory tract infections. This study was designed to investigate the viral cause of lower respiratory tract infections using sensitive molecular methods. PCR was applied to investigate 10 respiratory viruses in respiratory samples from 1,014 patients aged between 3 days to 76 years with acute lower respiratory tract infections. Of the 1,014 patients with lower respiratory tract infections, 288 (28.4%) had a viral infection. One hundred fifty‐five (53.8%) presented with bronchiolitis, 100 (43.7%) with pneumonia, and 33 (11.5%) with croup. One hundred six (36.8%) and 99 (34.4%) patients had evidence of respiratory syncytial virus and human rhinoviruses infections, respectively. Adenoviruses were detected in 44 (15.2%) patients, while influenza A virus in 21 (7.3%) patients. The majority of respiratory syncytial virus infections (84%) were among patients aged <1 year. Similarly, of the 99 patients infected by human rhinoviruses, 50 (50.5%) were also among this age group. In contrast, most of influenza A virus infections, 12 of 21 (57.1%), were among patients aged over 16 years. Parainfluenza virus‐2 and human coronaviruses were not detected in any of the patients' samples. Over the 3‐year period, most of the hospitalized patients were seen during the autumn and winter months from October through March. These data show that respiratory syncytial virus and human rhinoviruses may be the major causes of lower respiratory tract infections in children admitted to hospital in Kuwait. J. Med. Virol. 82:1462–1467, 2010. © 2010 Wiley‐Liss, Inc.
Croup
Respiratory tract
Rhinovirus
Pneumovirus
Human Parainfluenza Virus
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Objective
To investigate the epidemiological and clinical characteristics of human parainfluenza virus (HPIV) types 1 to 4 (HPIV1 to 4) infections among hospitalized children with acute lower respiratory tract infections, so as to evaluate the effects of HPIV4 on lower respiratory tract infections in children.
Methods
From January, 2015 to December, 2017, a total of 5 030 nasopharynal aspirate samples were collected from hospitalized children aged 0-14 years old with acute lower respiratory tract infections in Children's Hospital of Shanghai. Reverse transcript fluroscent PCR was used to detect HPIV1-4 and five other common respiratory viruses. The differences of epidemiological and clinical characteristics of HPIV1 to 4 were analyzed by chi-square test.
Results
From 5 030 child patients, 138 were positive of HPIV1 (2.74%), 31 were positive of HPIV2 (0.62%), 432 were positive of HPIV3 (8.59%) and 171 were positive of HPIV4 (3.40%). Co-infection rate of HPIV with 5 other common respiratory viruses were 10.23% (79/772). The differences of the positive rates of HPV1 to 4 among children of different ages and among different seasons were statistically significant. Comparing to HPIV3, children with HPIV4 infections showed statistically significant differences in clinical features, including cough, fever and diarrhea.
Conclusions
The positive rate of HPIV4 in child patients of acute lower respiratory tract infections was only lower than that of HPIV3. This should be concerned in clinical practice.
Key words:
Human parainfluenza virus; Acute lower respiratory tract infection; Epidemiological characteristics; Clinical features
Human Parainfluenza Virus
Respiratory tract
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Background In Madagascar, very little is known about the etiology and prevalence of acute respiratory infections (ARIs) in a rural tropical area. Recent data are needed to determine the viral and atypical bacterial etiologies in children with defined clinical manifestations of ARIs. Methods During one year, we conducted a prospective study on ARIs in children between 2 to 59 months in the community hospital of Ampasimanjeva, located in the south-east of Madagascar. Respiratory samples were analyzed by multiplex real-time RT-PCR, including 18 viruses and 2 atypical bacteria. The various episodes of ARI were grouped into four clinical manifestations with well-documented diagnosis: "Community Acquired Pneumonia"(CAP, group I), "Other acute lower respiratory infections (Other ALRIs, group II)", "Upper respiratory tract infections with cough (URTIs with cough, group III)"and "Upper respiratory tract infections without cough (URTIs without cough, group IV)". Results 295 children were included in the study between February 2010 and February 2011. Viruses and/or atypical bacteria respiratory pathogens were detected in 74.6% of samples, the rate of co-infection was 27.3%. Human rhinovirus (HRV; 20.5%), metapneumovirus (HMPV A/B, 13.8%), coronaviruses (HCoV, 12.5%), parainfluenza virus (HPIV, 11.8%) and respiratory syncytial virus A and B (RSV A/B, 11.8%) were the most detected. HRV was predominantly single detected (23.8%) in all the clinical groups while HMPV A/B (23.9%) was mainly related to CAP (group I), HPIV (17.3%) to the "Other ALRIs" (group II), RSV A/B (19.5%) predominated in the group "URTIs with cough" (group III) and Adenovirus (HAdV, 17.8%) was mainly detected in the "without cough" (group IV). Interpretation This study describes for the first time the etiology of respiratory infections in febrile children under 5 years in a malaria rural area of Madagascar and highlights the role of respiratory viruses in a well clinically defined population of ARIs.
Rhinovirus
Etiology
Human Parainfluenza Virus
Respiratory tract
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The epidemiology of atopic dermatitis, F. Schultz Larsen epidemiology of contract dermatitis, H.A. Smit and P.J. Coenraads epidemiology of urticaria, T. Schafer and J. Ring epidemiology of allergic rhinitis, B. Sibbald epidemiology of asthma, M.L. Burr epidemiology of allergic occupational lung diseases, K.M. Venables epidemiology of food related clinical symptoms in childhood, S. Strobel epidemiology of insect sting allergy, U.R. Muller epidemiology of allergic drug reactions, R. Hoigne, et al genetic aspects of atopy, W.O.C.M. Cookson epidemiology of factors which promote or protect against allergy, L. Nilsson and B. Bjorksten.
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Quantitation of respiratory viruses by PCR could potentially aid in clinical interpretation of PCR results. We conducted a study in children admitted with acute respiratory tract infections to study correlations between the clinical course of illness and semiquantitative detection of 14 respiratory viruses. Clinical improvement was associated with reduction of viral quantity after 3 days of hospitalization.
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