Paclitaxel–carboplatin for advanced or recurrent carcinosarcoma of the uterus: the Japan Uterine Sarcoma Group and Tohoku Gynecologic Cancer Unit Study
Tadao TakanoTakeo OtsukiHideki TokunagaMasafumi ToyoshimaHiroki UtsunomiyaSatoru NagaseHitoshi NiikuraKiyoshi ItoNobuo YaegashiHidekazu YamadaToru TaseMasahiro KagabuTadahiro ShojiToru SugiyamaNaoki SatoToshio FujimotoYukihiro TeradaKenji NakaharaHirohisa KurachiYoshihito YokoyamaHideki MizunumaShu SoedaHiroshi NishiyamaTakashi MatsumotoShinya SatoMuneaki ShimadaJunzo Kigawa
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Carcinosarcoma
Carboplatin
Surgical oncology
Gynecologic oncology
Gynecologic cancer
First-line ovarian cancer platinum doublet is paclitaxel-carboplatin. Superiority of weekly paclitaxel schedules has not been confirmed; however, a novel schedule with both drugs given weekly (days 1, 8, 15) followed by a 2-week break may be advantageous to some.
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调查 CMNa 的效果的目的在操作以后的先进卵巢的癌症病人在提高的 CA125 层次上与 paclitaxel 和 carboplatin 结合了。CMNa 的效果在 25 个操作以后的先进卵巢的癌症病人在提高的 CA125 层次上与 paclitaxel 和 carboplatin 相结合的方法回顾地被分析并且与那些相比在 20 个控制案例中。结果在 1 化疗骑车以后， CA125 与控制，而是有的不统计的意义相比铺平有的减少的趋势。当时在化疗的二个周期以后， CA125 层次在控制与那些相比更快减少了。在二个组的副作用是相似的。与 paclitaxel 和 carboplatine 相结合的结论 CMNa 比 paclitaxel 和 carboplatin 在操作以后的先进卵巢的癌症的治疗有提高的 CA125 层次在减少中有更强壮的效果，它显示 CMNa 在 paclitaxel 和 carboplatin 的化疗上有敏化 chemo 效果。
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A dose-dense weekly schedule of paclitaxel (resulting in a greater frequency of drug delivery) plus carboplatin every 3 weeks or the addition of bevacizumab to paclitaxel and carboplatin administered every 3 weeks has shown efficacy in ovarian cancer. We proposed to determine whether dose-dense weekly paclitaxel and carboplatin would prolong progression-free survival as compared with paclitaxel and carboplatin administered every 3 weeks among patients receiving and those not receiving bevacizumab.
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AbstractThe combination of carboplatin and paclitaxel is widely used to treat multiple solid tumors including ovarian, lung and breast cancer. Usually these drugs are given simultaneously with little regard to the importance of scheduling to obtain a maximal response. To investigate the importance of sequencing, the human breast Bcap37 and ovarian OV2008 cancer cell lines were exposed to carboplatin and paclitaxel in three different sequences: 1) pretreatment with paclitaxel followed by carboplatin; 2) pretreatment of carboplatin followed by paclitaxel and 3) simultaneous treatment with these two agents. The combination of carboplatin and paclitaxel resulted in antagonistic interactions when tumor cells were exposed to carboplatin prior to paclitaxel or exposed to the two drugs simultaneously, but there was little antagonistic interaction observed when paclitaxel was administered before carboplatin. Biochemical examination revealed that pretreatment or cotreatment of carboplatin inhibited paclitaxel-induced IκBα degradation and bcl-2 phosphorylation. Further analyses demonstrated that carboplatin could significantly interfere with the cytotoxic effects of paclitaxel on both mitotic arrest and apoptotic cell death unless paclitaxel was administered before carboplatin. These results indicate that the interaction between paclitaxel and carboplatin is highly schedule dependent. The optimal schedule for this combination is sequential exposure of paclitaxel followed by carboplatin.
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