Osteopontin gene haplotypes correlate with multiple sclerosis development and progression
Annalisa ChiocchettiCristoforo ComiManuela IndelicatoLuca CastelliRiccardo MesturiniThea BensiMaría Clorinda MazzarinoMara GiordanoSandra D’AlfonsoPatricia Momigliano‐RichiardiMaria LiguoriMarino ZorzonAntonio AmorosoMaria TrojanoFrancesco MonacoMaurizio LeoneCorrado MagnaniUmberto Dianzani
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Osteopontin
To study the role of osteopontin, we did cell adhesion and ALP assays of rat bone marrow osteoblastic cells (RBMO) on collagen Type I and osteopontin surfaces. The RBMO proved to adhere much more strongly to the osteopontin and to have higher ALP activity on the osteopontin, which suggests that pre-osteoblasts differentiate into osteoblasts that form bone by recognizing osteopontins.
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Pathogenesis
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Phosphoprotein
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Mineralized tissues
Hard tissue
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Objective To explore the effect of osteopontin(OPN) as marker in colon cancer tissue and analyze the relationship between osteopontin and recurrence.Methods ELISA method was used to determine the serum levels of osteopontin in 58 patients with colon cancer(observation group) and 22 cases of normal subjects(control group);semi-quantity RT-PCR was used to detect the expression of osteopontin in tissues.The expression level of OPN mRNA in colon cancer tissue and serum OPN level in 23 recurrence cases and 35 non-recurrence cases one year after operation were observed.Results The OPN mRNA expression in colon cancer tissue and the serum osteopontin level in patients in observation group were higher than those in control group(P0.01).The OPN mRNA expression and the serum level in patients with recurrence one year after operation were higher than those without recurrence(P0.01).Conclusion Osteopontin is one of the tumor markers and it could be used in diagnosis and prognosis evaluation of colon cancer.
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Osteopontin
Immunoprecipitation
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Objective To explore the expression of osteopontin in human gliomas and its clinical meanings. Methods The expression of osteopontin was determined by immunohistochemical stain in 10 cases of normal brain tissues and in 58 cases of gliomas. The relationship of osteopontin expression with pathological grade of gliomas and prognosis of patients with gliomas was analyzed. Results No expression of osteopontin was found in the normal brain tissues. The positive cell rates of osteopontin expression in grades Ⅰ, Ⅱ, Ⅲ and Ⅳ gliomas were 11.3%±6.2%, 21.8%±11.2%, 36.7%±18.3% and 49.4%±16.5% respectively. There was significant difference in osteopontin expression among the gliomas of different pathological grades (P0.05). Two year-survival rates in patients with high and low expressions of osteopontin was 40.6%(13/32) and 76.9%(20/26) respectively. There was significant difference in two year-survive rate beween the patients with high expression of osteopontin and patients with low exptrssion of osteopontin (P0.05). Conclusion Osteopontin may play an important role in the development of human brain gliomas. The expression of osteopontin is asso-ciated with pathological grade of gliomas and prognosis in the patients with gliomas.
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Osteopontin is an RGDS-containing protein which acts as an intercellular signaling molecule as well as a cellular attachment protein. Expression of osteopontin has been observed in the joints of patients with rheumatoid arthritis as well as osteoarthritis. However, the functions of osteopontin in such diseased articular components have not yet been elucidated. Recent investigations using knockout mice lacking osteopontin indicated that the presence of osteopontin could play a role in the development of arthritis induced by injection with monoclonal antibodies raised against type II collagen.
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