Trianthema portulacastrum L. reverses hepatic lipid peroxidation, glutathione status and activities of related antioxidant enzymes in carbon tetrachloride-induced chronic liver damage in mice
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Lipid peroxidation and serum catalase activity were assessed in 63 chronic alcoholics. 41 of them had renal lesions. The latter had more profound inhibition of blood serum catalase activity and distinct enhancement of lipid peroxidation. A reverse correlation exists between low catalase activity and lipid peroxidation activation in chronic alcoholics.
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Enzymatic activities of glutathione peroxidase, glutathione-S-transferase, glutathione reductase and catalase, as well as the glutathione content were measured in the brain tissue of regularly cycling rats at dioestrus, proestrus and estrus. The activity of glutathione peroxidase was found to be suppressed at proestrus, whereas that of catalase was increased at dioestrus. Glutathione transferase and glutathione reductase activities, as well as the glutathione content appeared to be stable during the oestrous cycle. These results suggest that, in the female rat, glutathione peroxidase and catalase activities in the brain tissue are influenced by the ovarian hormone status.
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비타민 E와 C 복합섭취가 GPX, GRD의 활성에 미치는 영향. 운동과학, 제10권 제1호. 13-20, 2001. 비타민 E와 C 복합섭취가 GPX(glutathione peroxidase), GRD(glutathione reductase)의 체내 활성을 증가시켜 산화적 스트레스를 야기시키는 운동강도에서 발생하는 산화적 손상을 방어할 수 있는지를 규명하고자 하였다.
이를 위해 41명의 피험자를 대상으로 항산화제와 운동처치를 5주간 실시한 후 비운동시(Non-exercise) 저강도(AT80%), 고강도(AT110%) 운동시 GPX, GRD 활성화 정도를 비교 분석하고, 비타민 복합섭취 집단과 위약집단에 따른 GPD, GRD의 활성화 정도를 비교 분석하였다.
연구 결과 고강도 운동시 GPX, GRD의 활성이 증가하는 것과 비타민 복합섭취집단과 위약집단과의 유의한 차이가 있는 것으로 볼 때 고강도(AT110%)운동은 산화스트레스를 일으키는 것을 알 수 있었다. 또한 장기간의 비타민 복합섭취는 GPX, GRD의 활성을 증가시키는 것으로 나타났다. 다시 말하면, 고강도 운동은 산화적 스트레스를 유발하여 체내 산화적 손상을 야기시키는 것을 추정할 수 있었으며, 하지만 장기간의 비타민 복합섭취가 고강도 운동으로 인한 산화스트레스를 감소시키는 것으로 보아 혈중 지질과산화물의 농도를 경감시키는 효과가 있는 것을 추정할 수 있었다. 이러한 결과로 볼 때 고강도 운동시 장기간의 항산화 섭취가 체내에 생성되는 지질 과산화 물질의 농도를 감소시킨 것으로 생각되며, 비타민이 체내 지질과산화물 생성을 억제하여 산화스트레스로부터 방어작용을 하는 것으로 추정할 수 있었다. 즉, 비타민 E와 C의 복합섭취가 충분히 지질과산화물에 의한 체내 산화스트레스를 감소시킬 수 있는 것으로 나타났다.
비타민 복합섭취를 통해서 산화적 스트레스 감소와 항산화효소의 활성을 증가시키는 것으로 보아 비타민 E+C가 적정강도를 벗어난 과도한 운동에 의한 산화적 손상을 방어할 수 있음을 알 수 있었다.
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Glutaredoxin
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The results of glutathione peroxidase and glutathione reductase activity in spermatozoa of patients with different forms pathospermia are presented in the paper. It was shown that glutathione peroxidase and glutathione reductase activity in sperm cells of patients is reduced in comparison with healthy men with preserved fertility. However, the most expressed changes in the activity of glutathione peroxidase and glutathione reductase are in spermatozoa of infertile men with associated forms patospermia and leucospermia. These changes indicate exhaustion of compensatory mechanisms of glutathione antioxidant system in the sperm cells of infertile men with pahospermia.
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The correlation between changes in activities of glutathione peroxidase and glutathione reductase in heart of rats during development of adrenaline myocarditis and intensity of free radical processes estimated by biochemiluminesce parameters and the content of lipoperoxidation products was demonstrated. The maximal increase of glutathione peroxidase and glutathione reductase activities (in 1.8 and 1.4 times accordingly) was observed t 24 h after the development of the pathological process; this coincided with the maximum intensity of prosesses of free radical oxidation. Using combination of reverse transcriptions with real-time polymerase chain reaction the cardiac mRNA levels of glutathione peroxidase and glutathione reductase genes were determined during the development of adrenaline myocarditis in rats. Analysis of expression of glutathione peroxidase and glutathione reductase genes showed, that the level of this transcripts demonstrated 2,8- and 7,3- increase in rats with adrenaline myocarditis, respectively. Obviously, overexpression of these enzymes can increase the resistance of cardiomyocites to oxidative stress.
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1. Changes in liver glutathione reductase and glutathione peroxidase activities in relation to age and sex of rats were measured. Oxidation of GSH was correlated with glutathione peroxidase activity. 2. Glutathione reductase activity in foetal rat liver was about 65% of the adult value. It increased to a value slightly higher than the adult one at about 2-3 days, decreased until about 16 days and then rose after weaning to a maximum at about 31 days, finally reaching adult values at about 45 days old. 3. Weaning rats on to an artificial rat-milk diet prevented the rise in glutathione reductase activity associated with weaning on to the usual diet high in carbohydrate. 4. In male rats glutathione peroxidase activity in the liver increased steadily up to adult values. There were no differences between male and female rats until sexual maturity, when, in females, the activity increased abruptly to an adult value that was about 80% higher than that in males. 5. The rate of GSH oxidation in rat liver homogenates increased steadily from 3 days until maturity, when the rate of oxidation was about 50% higher in female than in male liver. 6. In the liver a positive correlation between glutathione peroxidase activity and GSH oxidation was found. 7. It is suggested that the coupled oxidation-reduction through glutathione reductase and glutathione peroxidase is important for determining the redox state of glutathione and of NADP, and also for controlling the degradation of hydroperoxides. 8. Changes in glutathione reductase and glutathione peroxidase activities are discussed in relation to the redox state of glutathione and NADP and to their effects on the concentration of free CoA in rat liver and its possible action on ketogenesis and lipogenesis.
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Thiobarbituric acid
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