Nucleotide Sequence and Characterization of Human Papillomavirus Type 83, a Novel Genital Papillomavirus
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Sequence (biology)
Bovine papillomavirus
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Papillomaviridae
Papillomavirus induce benign tumours (papillomas) in a variety of animals. The papillomas generally regress but occassionally persist and may eventually progress to squamous cell carcinoma. One of the most extensively studies papillomaviruses is bovine papillomavirus type 4 (BPV4). BPV-4 induces papillomas of the upper alimentary canal which are at high risk of progressing to cancer in cattle eating bracken fern. In this review, several aspects of the biology of the virus are described and compared with other papillomavirus systems, including regulation of transcription of the viral oncogenes, function of the viral oncoproteins, cooperation between virus and chemical cofactors, and prophylactic and therapeutic vaccination programmes.
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The cloning and partial characterization of human papillomavirus (HPV) type 29 is presented. By hybridization analyses, this virus appears to be related to HPV types associated with common warts and HPV types associated with flat warts.
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A cutaneous fibropapilloma was found on a Scottish red deer (Cervus elaphus), and a papillomavirus was isolated from it. The virus appeared to be related to bovine papillomavirus type 1 (BPV1) or type 2 (BPV2) because: (i) it cross-reacted in peroxidase-antiperoxidase tests with antisera raised against these virions; (ii) BPV1 and BPV2 DNAs cross-hybridized to the red deer papillomavirus in situ; and (iii) BPV1 and/or BPV2 DNA cross-hybridized to the red deer papillomavirus DNA on Southern blots under conditions of high stringency. These tests also revealed a unique restriction enzyme cleavage pattern for the red deer papillomavirus DNA.
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The DNAs of different members of the Papillomavirus genus of papovaviruses were analyzed for nucleotide sequence homology. Under standard hybridization conditions (Tm - 28 degrees C), no homology was detectable among the genomes of human papillomavirus type 1 (HPV-1), bovine papillomavirus type 2 (BPV-2), or cottontail rabbit (Shope) papillomavirus (CRPV). However, under less stringent conditions (i.e., Tm - 43 degrees C), stable hybrids were formed between radiolabeled DNAs of CRPV, BPV-1, or BPV-2 and the HindIII-HpaI A, B, and C fragments of HPV-1. Under these same conditions, radiolabeled CRPV and HPV-1 DNAs formed stable hybrids with HincII B and C fragments of BPV-2 DNA. These results indicate that there are regions of homology with as much as 70% base match among all these papillomavirus genomes. Furthermore, unlabeled HPV-1 DNA competitively inhibited the specific hybridization of radiolabeled CRPV DNA to bpv-2 DNA fragments, indicating that the homologous DNA segments are common among these remotely related papillomavirus genomes. These conserved sequences are specific for the Papillomavirus genus of papovaviruses as evidenced by the lack of hybridization between HPV-1 DNA and either simian virus 40 or human papovavirus BK DNA under identical conditions. These results indicate a close evolutionary relationship among the papillomaviruses and further establish the papillomaviruses and polyoma viruses as distinct genera.
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Epidermodysplasia verruciformis
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SUMMARY The late region of bovine papillomavirus type 2 (BPV-2) DNA has been identified. The complete nucleotide sequence of the region was determined and revealed two large open reading frames. The DNA sequence results and the predicted amino acid sequence of putative polypeptides encoded by this region are presented. Comparative analysis of the BPV-2 late region and the corresponding area of BPV-1 was performed. This study demonstrates that identical genetic organization and considerable nucleotide sequence conservation exists between these two serotypes.
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No AccessJournal of UrologyUrological Survey1 Aug 2017Re: Genital Human Papillomavirus Infection Progression to External Genital Lesions: The HIM Study Sam S. ChangMD Sam S. ChangSam S. Chang More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.05.003AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Re: Genital Human Papillomavirus Infection Progression to External Genital Lesions: The HIM Study." The Journal of Urology, 198(2), p. 254 © 2017 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 198Issue 2August 2017Page: 254 Advertisement Copyright & Permissions© 2017 by American Urological Association Education and Research, Inc.MetricsAuthor Information Sam S. Chang More articles by this author Expand All Advertisement PDF downloadLoading ...
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