Bistabercarpamines A and B, first vobasinyl-chippiine-type bisindole alkaloid from Tabernaemontana corymbosa
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Keywords:
Apocynaceae
Monoterpene
Indole alkaloid
Chirality
Absolute Configuration
The roots of Aspidosperma polyneuron, family Apocynaceae, were subjected to chemical and biological investigations. From an ethanolic extract of the roots, the new alkaloid 2,7-dihydroxyquebrachamine (1) was isolated. The structure was established mainly from 1D and 2D NMR spectroscopic and mass spectrometric data. The 1D and 2D NMR spectra were also used to assign all the 1 H and 13 C chemical shifts of this alkaloid. Artemia salina was used for a preliminary investigation of biological activity.
Apocynaceae
Aspidosperma
Artemia salina
Chemical structure
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A new sarpagine-type indole alkaloid (1), together with nine known alkaloids (2 – 9), were isolated from the stems of Alstonia angustifolia Wall. ex A. DC. (Apocynaceae) collected in South Vietnam. Compounds 1 – 10 were evaluated for their NF-κB (p65) inhibitory activities against HT-29 cells in an ELISA assay. The new sarpagine alkaloid (1), was found to show significant NF-κB inhibitory activity (ED50= 1.2 µM). Furthermore, all the isolates (1 – 10) were tested in vitro for their antileishmanial activity, and compounds (1 – 4, 6, 8 – 10) were found to show leishmaniacidal activities.
Apocynaceae
Indole alkaloid
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Apocynaceae
Indole alkaloid
Ajmaline
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Monoterpene indole alkaloids (MIAs) constitute a broad class of nitrogen-containing plant-derived natural products composed of more than 3000 members.[1] This natural product class is found in hundreds of plant species from the Apocynaceae, Loganiaceae, Rubiaceae, Icacinaceae, Nyssaceae, and Gelsemiaceae plant families. Throughout the six past decades, the structural intricacies and biological activities of these molecules have captured the interest of many researchers all over the world.
Apocynaceae
Monoterpene
Natural product
Indole alkaloid
Chemical space
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A new monoterpenoid indole alkaloid, 10-hydroxy-N(α)-demethyl-19,20-dehydroraumacline (1), was isolated as a mixture of E- and Z-isomers from hairy root culture of Rauvolfia serpentina Benth. ex Kurz (Apocynaceae) and the structure was determined by 1D and 2D NMR analyses. The new indole alkaloid represents the first naturally occurring alkaloid of the raumacline group and its putative biosynthetical pathway is discussed.
Apocynaceae
Indole alkaloid
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A new indole alkaloid of the pyridocarbazole type, named 6N-hydroxy-olivacine, and two known compounds, 2N-oxide-olivacine and olivacine, were isolated from roots of Peschiera affinis. The structures of the compounds were determined by spectroscopic {IR and extensive NMR (COSY, HMQC, HMBCand NOESY)} and EIMS analysis.
Apocynaceae
Indole alkaloid
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Abstract A novel monoterpene alkaloid, named incarvine G, was isolated from the Incarvillea sinensis Lam. Its chemical structure was elucidated using comprehensive spectroscopic methods. Incarvine G is an ester compound comprised of a monoterpene alkaloid and glucose. This compound showed evident inhibition on cell migration, invasion, and cytoskeleton formation of human MDA‐MB‐231 with low cytotoxicity.
Monoterpene
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Indole alkaloid
Chemical transformation
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A new monoterpenoid indole alkaloid, 3-oxo-rhazinilam (1), was isolated from intergeneric somatic hybrid cell cultures of Rauvolfia serpentina and Rhazya stricta, and the structure was determined by detailed 1D and 2D NMR analysis. It was also proved that 3-oxo-rhazinilam (1) is a natural constituent of the hybrid cells.
Apocynaceae
Indole alkaloid
Somatic fusion
Monoterpene
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