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    Technologic parameter optimization of gas quenching process using response surface method
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    NaOH Treated Eggshells   (TES) was investigated for the removal of Acide Orange 7 (AO7) from aqueous solution using the continuous method was modeled by response surface methodology (RSM) and was optimized using Box–Behnken design (BBD) . Fixed bed adsorption has become a frequently used in wastewater treatment processes. Various low cost adsorbents have been studied for their applicability in treatment of different types of effluents.  In this work, the intention of the study was to explore the efficacy and feasibility for azo dye, AO7 adsorption onto fixed bed column of TES. The effect of operating parameters such as flow rate, initial dye concentration, and bed height were exploited in this study. The studies confirmed that the breakthrough curves were dependent on flow rate, initial dye concentration solution of AO7 and bed depth.The precision of the equation obtained by Box–Behnken design (BBD) utility for modeling and optimization by response surface methodology RSM was confirmed by the analysis of variance (ANOVA) and calculation of correlation coefficient relating the predicted and the experimental values of removal of dye. The results revealed a good agreement between the predicted values, as obtained by the model, and the experimental values for AO7. The optimum conditions proposed by Box–Behnken design (BBD) to reach the maximum dye removal through adsorption process. Under the optimum conditions, the removal efficiency of AO7 were 89.89%.The application of response surface methodology in order to optimize using Box–Behnken design (BBD) . The research on modeling adsorption by RSM has been highly developed and The TES was shown to be suitable adsorbent for adsorption of AO7 using fixed-bed adsorption column.
    Box–Behnken design
    The current study focusses on the optimization of Copper oxide nanoparticles (CuO NPs) biosynthesis with Alternanthera sessilis (L.) extract using response surface methodology (RSM). The effect of time, pH, and extract to metal concentration ratio on the yield of synthesized nanoparticles (NPs) were estimated using Box–Behnken design. The influence of each of the parameters, as mentioned earlier, was determined by synthesizing nanoparticles under different conditions. A total of 29 experimental runs were carried out to estimate the crucial parameters. Extract to the metal ratio was found to be the vital parameter for yield optimization based on the p-values (p-value < 0.05). The physicochemical property of NPs, like size, was estimated to be in the range of 10-20 nm. In zebrafish, 48 hpf and 72 hpf were measured at 90 µM to reduce dysfunction and mortality during organ development. These results can have a valuable impact on eco-toxicological effects.
    Box–Behnken design
    Copper oxide
    Rotatability property for the Small Box-Behnken design is discussed in this paper. This paper aimed at applying a measure of obtaining percentage rotatability on the Small Box-Behnken designs to determine if the Small Box-behnken designs are rotatable or not and investigated the extent of rotatability in terms of percentage. The factors, q, considered range from 3 to 11. The results showed that for factors q, the Small Box-Behnken design is rotatable for q = 3 factors, near rotatable for q = 4, 7 factors and not rotatable for q = 5, 6, 8, 9, 10 and 11 factors.
    Box–Behnken design
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    Tunics corm saffron (TCS) is a low-cost adsorbent that removes methylene blue (MB) from an aqueous solution. The TCS was characterized using FTIR and SEM analysis. The influence of MB adsorption variables such as TCS dose (0.4–2.4 g L−1), contact time (0–120 min), MB dye concentration (100–500 mg L−1) was optimized Box–Behnken design (BBD) combined with response surface methodology (RSM) modeling. All three variables among the main parameters significantly affected the removal efficiency by applying the quadratic regression analysis. The results showed that the predicted values for MB adsorption were close to the experimental values and were in good agreement. Besides, the r2 value (r2=0.970) indicates that the regression can predict response for the adsorption process in the studied range. The optimum BBD-RSM for MB removal of 89.48 % was recorded at a TCS dose of 1.78 g L−1, contact time of 56 min, MB dye concentration of 176 mg L–1 at solution pH of 5.4 temperature 21 °C. Excellent regeneration of TCS to remove MB in sixth consecutive adsorption-desorption cycles. This work highlights that TCS offers tremendous potential as a low-cost for organic dyes removal from wastewaters.
    Box–Behnken design
    Methylene blue
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    冗余的茶废物的有效处理对环境保护和垃圾资源的全面利用关键。在这个工作,当吸着剂在一个批实验被调查,从水的答案使用的甲基橘子(瞬间) 的移动花了茶叶子。首先,象温度,吸附时间,花的茶叶子的剂量,和瞬间的起始的集中那样的各种各样的参数的效果被调查。然后,基于 Box-Behnken 设计,反应表面方法论(RSM ) 被采用获得最佳吸附条件。最佳的条件能在 9.75 mg 獥汵獴搠浥湯瑳慲整 ? 桴瑡琠敨倠 ? 敃 ? ?? 汣獡 ? 愢瀭畬 ? 汰獵? 的瞬间的起始的集中被获得 ? 猯'T  ̄慣慴祬瑳 ? 慨 ?? 祴楰慣? 桴敲 ? 楤敭獮潩慮??? 栠敩慲' 詷 E 慣? 潰潲獵猠牴 ' 壮肭?桷捩 ? 慷 ? 慦潶慲汢? 潦 ? ?晲捡 ? 敲捡楴湯愠摮攠桮湡散 ? 桴 ? 硥潰?敲搠来敲 ? 景琠敨倠 ? 慮潮慰瑲捩敬吗?
    Box–Behnken design
    Methyl orange
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    Objective To optimize the formulation parameters of solid lipid nanoparticles(SLN) of silymarin by Box-Behnken experimental design.Methods A three-factor and three-level Box-Behnken experimental design was employed using emulsion evaporation-low temperature solidification technique to prepare SLN with silymarin as model drug.Response surface methodology was used to investigate the factors affecting entrapment efficiency(EE),drug loading(DL),and particle size.Binomial mathematical model-optimized formulation was established with EE,DL,and particle size as response values.Results The optimal formulation was as follows: the amount of glycerol monostearate was 5.05%,the concentration of Poloxamer 188 was 7.25%,and the amount of drug was 15%.Conclusion The Box-Behnken experimental design could be used to optimize the SLN of silymarin.
    Box–Behnken design
    Solid lipid nanoparticle
    Design of experiments
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