A floating metal microelectrode array for chronic implantation
137
Citation
21
Reference
10
Related Paper
Citation Trend
Keywords:
Multielectrode array
Electrode array
Biocompatible material
Plotter
As a method of observing regeneration of damaged nerves, research is being conducted on analyzing the electric signals of nerve fibers that are damaged and regenerating by implanting a microelectrode array between those nerves. Microelectrode arrays possess high impedance and a unique phase characteristic according to their structural features, thus it requires a phase linearity test and an impedance test to prevent neural signal distortion. Therefore, this paper analyzes the features of microelectrode array and designs a bioamplifier. We also measured signals from sciatic nerves in rats with microelectrode array.
Multielectrode array
SIGNAL (programming language)
Distortion (music)
Cite
Citations (1)
Multielectrode array
Cite
Citations (81)
As a method of observing regeneration of damaged nerves, research is being conducted on analyzing the electric signals of nerve fibers that are damaged and regenerating by implanting a microelectrode array between those nerves. Microelectrode arrays possess high impedance and a unique phase characteristic according to their structural features, thus it requires a phase linearity test and an impedance test to prevent neural signal distortion. Therefore, this paper analyzes the features of microelectrode array and designs a bioamplifier. We also measured signals from sciatic nerves in rats with microelectrode array.
Multielectrode array
SIGNAL (programming language)
Distortion (music)
Cite
Citations (0)
Objectives To design and fabricate implantable epi-retinal microelectrode array for the purpose of retinal repair,and perform test on the features of the array.Methods With parylene as flexible substrate material and Pt as electrode material,monolayer microelectrode array was designed and fabricated,and electric characteristics of the array were measured with the three-electrode test system.Results Test results showed that morphological and electrochemical properties of the array met the design requirements.Conclusion The microelectrode array can be put in the in vivo electrophysiological experiments on animal.
Multielectrode array
Parylene
Electrode array
Retinal implant
Cite
Citations (0)
A novel 3D bio-stimulating microelectrode array was designed based on polyimide thin film for implantable artificial retina.Non-silicon MEMS technique was applied o fabricate the flexible microelectrode with the height of 80 μm,which is also bio-compatible and chemical stable.The microelectrode was then released from substrate by PDMS sacrificial layer process and packaged by polyimide and PDMS.Au was eletroplated on the surface of electrodes and pads to obtain bio-compatibility.The electrochemical properties of electrodes was detected by three-electrode method,and the impedance varied at the range of 1.5～0.3 kΩ and at the frequency 10-1～105 Hz.With the advantages of small size,light weight,high reliability and flexibility,the device is suitable for bio-stimulation.
Multielectrode array
Cite
Citations (0)
In this paper, we describe our all-titanium microelectrode array (tMEA) fabrication process and show that uncoated titanium microelectrodes are fully applicable to measuring field potentials (FPs) from neurons and cardiomyocytes. Many novel research questions require custom designed microelectrode configurations different from the few commercially available ones. As several different configurations may be needed especially in a prototyping phase, considerable time and cost savings in MEA fabrication can be achieved by omitting the additional low impedance microelectrode coating, usually made of titanium nitride (TiN) or platinum black, and have a simplified and easily processable MEA structure instead. Noise, impedance, and atomic force microscopy (AFM) characterization were performed to our uncoated titanium microelectrodes and commercial TiN coated microelectrodes and were supplemented by FP measurements from neurons and cardiomyocytes on both platforms. Despite the increased noise levels compared to commercial MEAs our tMEAs produced good FP measurements from neurons and cardiomyocytes. Thus, tMEAs offer a cost effective platform to develop custom designed electrode configurations and more complex monitoring environments.
Multielectrode array
Cite
Citations (8)
A method of fabricating flexible neural microelectrodes based on non-photosensitive polyimide PI-5J was proposed, and a novel flexible neural stimulating microelectrode array was designed and fabricated by the traditional photolithography process for animal implantation. The degeneration and electrical characteristics of this fabricated microelectrode array were tested in vitro. Its biocompatibility was tested in vivo. The results show the array's good degeneration-resistance, good biocompatibility and good electrical characteristics, which are the bases for its next stage tests in vivo. The fabrication method of the flexible microelectrode array proposed in the paper will promote the basic research on neural science, and the treatment, the rehabilitation of neural diseases.
Multielectrode array
Biocompatibility
Cite
Citations (0)
Planar electrode array is an important tool to evaluate perceptual or cognitive functions of the cortex and prosthetic applications. Many construction methods have been developed. To maximize the usefulness of an array electrode, a low-cost, precise, and flexible microelectrode array with low man power and short construction duration is crucial. In this study, we introduced an 8 × 8 microelectrode array on a flexible polyimide film through microelectronics fabrication. The array dimension was capable of covering the primary somatosensory cortex of a rat. The microelectrode array was insulated with biocompatible Parylene-C except of microelectrode tip. Each electrode tip was 66 μm height and separated with 0.5 mm to refine a detail somatic sensory processing. In pentobarbital anesthetized rats, stable spontaneous brain activity was successfully recorded through the electrode array. In addition, positive peaks of somatosensory evoked potentials (SEPs) elicited by stimulating rat's whisker pad, forepaw, hindpaw, and tail were obviously and consistently recorded. Latencies of SEPs increased as caudal part of the body was stimulated. The SEPs from stimulation of 4 body parts revealed different spatiotemporal patterns, which indicated a somatotopic organization of the rat. Our results demonstrated the superiority of the planar microelectrode array on the application of simultaneous recording and analysis of the brain activity in rats.
Multielectrode array
Electrode array
Cite
Citations (0)
Multielectrode array
Cite
Citations (102)
Microelectrode arrays play an important role in prosthetic implants for neural signal recording or applying electrical pulses stimulation to target nerve system. Safety and long-term reliability are essential requirements for microelectrode arrays applied in electrical stimulation. In design and fabrication of the microelectrode array, soft materials are generally chosen to be the substrate for the aim of achieving better compliance with the surrounding tissue while maintaining minimal damage. By flexing of the array to the surface, the array is capable of keeping a more stable electrical contact resulting in a significantly improved signal detected.In this study, we design and fabricate a flexible microelectrode array with gold as the electrode material and parylene-C as the substrate. The fabrication process of the array is presented. The in vitro electrochemical characteristics of the microelectrode are investigated by electrochemical impedance spectroscopy and cyclic voltammetry in a three-electrode electrochemical cell containing phosphate-buffered saline. Charge injection capacity measurements are carried out by multichannel systems and the CSC of the microarray is calculated.Electrochemical results showed that impedance decreased with frequency. The average impedance of the Au electrodes at 1 kHz was 36.54 ± 0.88 kΩ. The average phase angle at 1 kHz was - 73.52 ± 1.3°, and the CIC of the microelectrode was 22.3 µC/cm2. The results demonstrated that the microelectrode array performed as expected for neuronal signal recording or stimulation.With parylene-C as the substrate, the microarray has good flexibility. The electrochemical characteristics' results show that the array has the ability to resist any corrosion on metal-electrolyte interface and has good biocompatibility. This low-cost, flexible parylene-based, gold microelectrode array shows potential for use in implant neurological signal acquisition or neurostimulation applications.
Multielectrode array
SIGNAL (programming language)
Parylene
Electrode array
Cite
Citations (18)