MUC1 inhibits cell proliferation by a β-catenin-dependent mechanism
35
Citation
77
Reference
10
Related Paper
Citation Trend
Beta-catenin
Tumor progression
Cite
Citations (80)
The paper deals with the mechanisms o f synergic development of the region al high -tech industries be-tween Mainland and Taiwan.It analyzes the constitutes of the mechanism w hich include the drive mechanism,coupling mechanism,outside conditions controlling mechanism and self-organization mechanism and etc.In addition,the paper presents a systematic netw ork of mechanism.
Mainland
Cite
Citations (0)
microRNAs (miRNAs) dysregulation is widely involved in cancer progression and contributed to sustained cell proliferation by directly targeting multiple targets. Therefore, better understanding the underlying mechanism of miRNA in carcinogenesis may improve diagnostic and therapeutic strategies for malignancy. In our study, we found that mir-765 is upregulated in both hepatocellular carcinoma (HCC) cell lines and tissues, compared to human normal liver cell line and adjacent non-cancerous tissues, respectively. Overexpression of mir-765 increased HCC cells proliferation and tumorigenicity, whereas inhibition of mir-765 reverses this effect. Furthermore, we demonstrated that INPP4B as a direct target of mir-765 and ectopic expression of mir-765 repressed INPP4B expression, resulting in upregulation of p-AKT, Cyclin D1, and downregulation of p-FOXO3a, p21 expression in HCC. Strikingly, we found that silencing the expression of INPP4B is the essential biological function of miR-765 during HCC cell proliferation. Collectively, our findings reveal that miR-765 is a potential onco-miR that participates in carcinogenesis of human HCC by suppressing INPP4B expression, and might represent a potential therapeutic target for HCC patients.
Ectopic expression
Cyclin E1
Cite
Citations (59)
This paper ventures to explore the development of community sports and the innovation of its system and mechanism.It holds an opinion that the innovation of community sports system and mechanism may promote the sustained favourable development of community sports.To be specific,the innovation of community sports system covers the aspects of government guiding,social involvement,resources integration,etc.,while the innovation of community sports mechanism involves leadership mechanism,financing mechanism,mechanism of resources integration,mechanism of training community sports instructors and mechanism of evaluation and motivation.
Cite
Citations (0)
Beta-catenin
Cite
Citations (4)
Modernization of mechanisms is very important to the development of mechanical industry.Generalized mechanism,controllable mechanism,conceptual design of mechanism system,robot and walking machine mechanism,micro mechanism and micro drivers,bionic mechanism,and new type mechanism are the main research fields of modern mechanisms.The formation and application of mechatronics system is the symbol of the production of modern mechanisms.The leading differences between the modern mechanism and traditional mechanism lie in:different understanding to the meaning of mechanism,different components of machine,different design theory and method of mechanism.Modern mechanisms has a broad application prospect,it could make great effect on controllable mechanism,robot,micro mechanism,mechanical dynamical analysis,etc.
Bionics
Cite
Citations (0)
The paper presents an original method to determine the efficiency of a mechanism with cam and follower. The originality of this method consists in eliminating the friction modulus. In this research it analyses four types of cam mechanisms: 1.The mechanism with rotary cam and plate translated follower; 2.The mechanism with rotary cam and translated follower with roll; 3.The mechanism with rotary cam and rocking-follower with roll; 4.The mechanism with rotary cam and plate rocking-follower. For every kind of cam and follower mechanism one uses a different method to determine the most efficient design. We take into account the cam’s mechanism (distribution mechanism), which is the second mechanism in internal-combustion engines. The optimizing of this mechanism (the distribution mechanism), can improve the functionality of the engine and may increase the comfort of the vehicle too.
Cite
Citations (72)
Educational mechanism is correlation of each parts of educational phenomenon and their run mode,includes three basic style : administrative level mechanism,formally mechanism and function mechanism of edu-cation.On administrative level mechanism,we need to build an dynamic structure which middle-scopical priority together with microcosmic mechanism;On formally mechanism,we need a service-supervise mechanism of in-struction-service mechanism priority together with administration-scheme mechanism;On function mechanism,we need a dynamic mechanism of prompting and guarantee mechanism priority together with restriction mechan-ism.
Cite
Citations (0)
The paper proposes the course model of management synergy mechanism(MSM) on the basis of determining the meaning of MSM and divides the MSM into forming mechanism and realizing mechanism.It gives the definition and the mechanism of the assessment mechanism and interests mechanism in the forming mechanism,and discusses the mechanism of the synergy opportunity discerning,the pre-assessing of synergy value,communicating,combining,controlling and feedbacking and so on in the realizing mechanism.
Value (mathematics)
Cite
Citations (3)
The original meaning of refers to the interaction among different components of the machine and the way of its operation.Social mechanism means the interaction among every parts of the society and the way of its operation,which consists of social level mechanism,social form mechanism and social functional mechanism.The social level mechanism mainly includes macro-level mechanism,meso-level mechanism and micro-level mechanism.The administrative-planned mechanism,guided-service mechanism and supervised-service mechanism are the basic categories of the social form mechanism.The promotion mechanism,guarantee mechanism and restriction mechanism compose the social function mechanism.The three kinds of mechanisms and their sub-categories have different connotations,but there are some internal and inevitable relations among them.The social mechanism,social Tizhi,social system and social principle are different categories but with internal and inevitable relations.It is helpful to make clear of the mechanism,understand the contents and regulations of mechanism reform and clarify the train of though of mechanism reform by exploring the theory of social mechanism.
Cite
Citations (0)