Involvement of nitric oxide signaling in mammalian Bax-induced terpenoid indole alkaloid production of Catharanthus roseus cells
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Catharanthus roseus
Indole alkaloid
Catharanthus roseus
Indole alkaloid
Apocynaceae
Subculture (biology)
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Catharanthus roseus
Indole alkaloid
Moiety
Apocynaceae
IC50
Monoterpene
Chemical structure
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Catharanthus roseus
Vindoline
Indole alkaloid
Apocynaceae
Secondary metabolism
Vinca
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Catharanthus roseus
Apocynaceae
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A new monoterpenoid indole alkaloid, 15,20-dehydro-3α-(2-oxopropyl) coronaridine (1), along with sixteen analogues (2-17) were isolated from the leaves of Catharanthus roseus cultivated in Yunnan. The new alkaloid was elucidated on the basis of extensive spectroscopic analysis, and the known alkaloids were identified by comparison with the reported spectroscopic data. Among them, alkaloid 16 was isolated from Catharanthus for the first time.
Catharanthus roseus
Apocynaceae
Indole alkaloid
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Catharanthus roseus
Indole alkaloid
Apocynaceae
Drought stress
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Catharanthus roseus
Indole alkaloid
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Using serpentine fluorescence as an indicator of alkaloid production in cultured Catharanthus roseus cells, 6 cell lines producing alkaloid in excess of 300 mg/l were selected from more than 2 × 105 individual colonies and their alkaloid production was monitored over a period of 8 years. Rapid loss of productivity invariably occurred during the first few months of cultivation, and spontaneous recovery of the initial production rates was never observed. Production of the indole alkaloid precursor, secologanin, followed the same pattern. Recovery of high alkaloid yielding strains was, however, possible at any time by repetition of the clonal selection procedure, but these strains were again instable. Clonal selection of high yielding plant cell strains apparently favours an inherent instability.
Catharanthus roseus
Indole alkaloid
Suspension culture
Apocynaceae
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Catharanthus roseus
Indole alkaloid
Zeatin
Apocynaceae
Bioconversion
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Object To investigate the effects of fungal elicitors derived from the fungi Fusarium solani and Aspergillum niger on the accumulation of indole alkaloids in Catharanthus roseus calli. Methods The total indole alkaloid was extracted after the calli were treated with fungal elicitors. Then, the determination of ajmalicine and catharanthine was carried out by RP HPLC. Results The two fungal elicitors stimulate the accumulation not only the total indole alkaloid but the ajmalicine and catharanthine. The optimal exposure time of the two fungal elicitors for different kinds of indole alkaloid was investigated. Conclusion The two fungal elicitors have obvious effect on the accumulation of indole alkaloid in C. roseus calli.
Catharanthus roseus
Indole alkaloid
Apocynaceae
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