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    Interrelationship of Purine and Pyrimidine Metabolism
    Handbook of experimental pharmacology (1978)
    Masamiti Tatibana
    Purine metabolism
    Pyrimidine metabolism
    De novo synthesis
    Citations (11)
    The effect of 6-mercaptopurine on nucleic acid biosynthesis in Escherichia coli.
    PubMed (1957)
    Mandel HgInscoe JkMaling HmSmith Pk
    The growth of Escherichia coli was inhibited partially by the carcinostatic purine analog, 6-mercaptopurine (6-MP), at a concentration of 3 mgm. per liter in a glucose-salts medium, without change in viability or gross morphology of the microorganisms. Simultaneous addition of 5 mgm. of guanine per liter of medium partially reversed this inhibition without the added guanine becoming the sole source of bacterial purines. DNA and RNA purines were isolated from bacteria grown with 5 mgm. of guanine-C 14 in the presence and absence of 3 mgm. of 6-MP per liter. The relative specific activities (RSA9s) of both RNA and DNA adenine obtained from cultures grown in the presence of 6-MP were approximately 60 per cent higher than those of control cultures, whereas the corresponding guanine fractions showed only a slight increase. Utilization of exogenous guanine for the same extent of growth was unaffected by 6-MP. The increase in the RSA9s of bacterial purines was due to a lessened dilution of the labeled exogenous purine by endogenous purine since experiments with labeled formate demonstrated a reduction in endogenous purine synthesis produced by 6-MP. Although this curtailment was approximately equal for adenine and guanine, 6-MP affected the RSA9s of the nucleic acid adenine fractions more than those of the guanine fractions because a larger proportion of adenine than guanine is endogenously synthesized when guanine-C 14 is added to the growth medium.
    Purine metabolism
    Hypoxanthine
    Citations (5)
    Methotrexate
    Springer eBooks (2016)
    Yedidia BenturYael Lurie
    Amethopterin
    Aminopterin
    Folic Acid Antagonists
    Citations (2)
    Purines and purine nucleoside analogues as antitumour agents
    Springer eBooks (1990)
    R. K. ROBINSGanesh D. Kini
    Purine metabolism
    Purine analogue
    Nucleoside analogue
    Citations (12)
    Methotrexate U.S.P. (Amethopterin) and Methotrexate Sodium
    American Journal of Health-System Pharmacy (1973)
    Journal Article Methotrexate U.S.P. (Amethopterin) and Methotrexate Sodium Get access American Journal of Hospital Pharmacy, Volume 30, Issue 6, 1 June 1973, Pages 542–548, https://doi.org/10.1093/ajhp/30.6.542 Published: 01 June 1973
    Amethopterin
    Citations (2)
    3′,5′-Ditritiomethotrexate as a Granulocyte Label
    Nature (1965)
    Joseph R. BertinoDavid G. JohnsP. AlmquistJ. W. HollingsworthE. Anthony Evans
    Amethopterin
    Folic Acid Antagonists
    Citations (7)
    Control of purine biosynthesis
    Archives of Biochemistry and Biophysics (1965)
    Michael L. MayArthur L. Koch
    Purine metabolism
    Pyrimidine metabolism
    De novo synthesis
    Citations (9)
    Direct demonstration of the active salvage of preformed purines by murine tumors
    Biochemical and Biophysical Research Communications (1990)
    Dana L. JohnsonRobert J. MullinDavid S. DuchStephen J. Benkovic
    Purine metabolism
    Nucleotide salvage
    De novo synthesis
    Citations (2)
    2 The Biochemical Basis for the Drug Actions of Purines
    Progress in medicinal chemistry (1970)
    John A. Montgomery
    Purine metabolism
    Catabolism
    Purine analogue
    Nucleoside analogue
    Citations (38)
    Purine and pyrimidine metabolism
    Proceedings of The Nutrition Society (1982)
    N. Zöllner
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    Pyrimidine metabolism
    Content (measure theory)
    Citations (57)