Fabrication and characterization of monodisperse PLGA–alginate core–shell microspheres with monodisperse size and homogeneous shells for controlled drug release
174
Citation
45
Reference
10
Related Paper
Citation Trend
Keywords:
PLGA
Dispersity
Dispersity
PLGA
Homogenizer
Cite
Citations (4)
Carrier system
Targeted drug delivery
Cite
Citations (61)
Targeted drug delivery
Biomimetic Materials
Biomimetic Synthesis
Biomimetics
Cite
Citations (154)
Erythrocyte, which is also known as red blood cells, has been extensively studied by scientists for their capability as a potential carrier for the delivery of drugs and drug-loaded microspheres. Resealed erythrocytes, as a drug delivery system has excellent capacity to enhance the therapeutic index and patient compliance. It has got tremendous potential to achieve site specific drug delivery with least wastage of drugs and it also prolong the release of drug. For the preparation of such drug-loaded carrier erythrocytes, the blood samples are simply collected from the organism of interest, and then the erythrocytes are separated from plasma. The drug is entrapped in the erythrocytes, and resealing the resultant cellular carriers. And because of this resealing process these carriers are called resealed erythrocytes. Erythrocytes are biocompatible, biodegradable and the most important advantages are that it possesses long circulation half lives. It can be easily prepared by simple technique and can be loaded along with a variety of biologically active compounds. The present review focuses on the potential applications of erythrocytes in drug delivery.
Blood circulation
Targeted drug delivery
Biocompatible material
Cite
Citations (1)
Objective To introduce the current application of poly(lactide-co-glycolide)(PLGA) nanoparticles or microparticles as the carriers of macromolecules.Method To review the related literatures comprehensively.Result PLGA and PLGA-based polymers are biocompatibile and biodegradable, and have been widely explored as carriers for the delivery of macromolecular therapeutics such as proteins, peptides.Conclusion PLGA can be blended with other adjuncts or modified to improve its property as drug carriers.PLGA nanoparticles or microparticles are promising carriers for the delivery of macromolecular therapeutics.
PLGA
Pharmaceutics
Biodegradable polymer
Cite
Citations (1)
Vesicular drug delivery system can be defined as highly ordered assemblies consisting of one or more concentric bilayers formed as a result of self-assembling of amphiphilic building blocks in presence of water. Vesicular drug delivery systems are particularly important for targeted delivery of drugs because of their ability to localize the activity of drug at the site or organ of action thereby lowering its concentration at the other sites in body. Vesicular drug delivery system sustains drug action at a predetermined rate, relatively constant (zero order kinetics), efficient drug level in the body, and simultaneously minimizes the undesirable side effects. It can also localize drug action in the diseased tissue or organ by targeted drug delivery using carriers or chemical derivatization. Different types of pharmaceutical carriers such as polymeric micelles, particulate systems, and macro- and micromolecules are presented in the form of novel drug delivery system for targeted delivery of drugs. Particulate type carrier also known as colloidal carrier system, includes lipid particles, micro- and nanoparticles, micro- and nanospheres, polymeric micelles and vesicular systems like liposomes, sphingosomes, niosomes, transfersomes, aquasomes, ufasomes, and so forth.
Niosome
Targeted drug delivery
Carrier system
Cite
Citations (154)
Chitosan can be used to prepare the carriers, such as nanoparticles (NPs), intelligent gels, microspheres, nano/microencapsulation, and so on. Its applications in the drug delivery are more broad. Dextran can be combined with drugs by non-covalent crosslinking method or covalent modification mode in the course of delivery. The applications of chitosan and dextran as carriers for drug delivery were summed up herein. Keywords: Applications, chitosan, carriers, dextran, drug delivery.
Microparticle
Targeted drug delivery
Cite
Citations (7)
Targeted drug delivery
Cite
Citations (83)