Cytological Diagnosis of Penicillium marneffei Infection
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Penicillium marneffei
Objective To discuss the clinical features of immunocompetent patients with Penicilliosis marneffei.Methods To analyze and summarize the clinical data of 4 immunocompetent patients with Penicilliosis marneffei.Results Clinical manifestation of patients centered on intermittent slight or mild fever,lymphadenectasis,skin eruptions,osteolytic destruction,anaemia,and leukocytosis.The cultural Penicillium marneffei in specimen such as blood,pus showed a higher positive rate.Amphotericin B and itraconazole was available in treatment.Conclusion Immunocompetent people can be infected by Penicillium marneffei,and they appear nonspecific in clinical manifestation after infection.A timely and effective antifungal therapy can improve the prognosis of patients.
Key words:
Penicillium marneffei; Infect; Treatment outcome
Penicillium marneffei
Leukocytosis
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Penicillium marneffei
Opportunistic infection
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Penicillium marneffei, a dimorphic fungus is a rare opportunistic pathogen. It is known to cause infection in immunocompromised patients and recently its occurrence in AIDS patients has been well-documented. Disease with Penicillium marneffei is even rarer among previously healthy individuals. The disease is endemic in Southeast Asia and China. Recognition of this rare disease is important because it is amenable to treatment. We report a case of P. marneffei infection in a previously healthy individual.
Penicillium marneffei
Dimorphic fungus
Opportunistic infection
Fungal pathogen
Rare disease
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Penicillium marneffei
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Disseminated penicilliosis (non-Penicillium marneffei) in an immuno-competent individual in Malaysia
Penicilliosis infection caused by Penicillium marneffei is the third most common opportunistic infection in Human Immunodeficiency Virus patients in South-east Asia; however, Penicillium infection caused by non- P. marneffei is uncommon. We present a case of an immunocompetent male with disseminated penicilliosis (non- P. marneffei) presenting with recurrent empyema. The case described illustrates the challenges in managing a complicated systemic infection and the outcomes of a delayed presentation, in a potentially treatable disease.
Penicillium marneffei
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Background: Penicillium marneffei infection is the emerging fun gal infection in the present day global scenario of HIV pandemic. P. marneffei is a dimorphic fungi with mycelial growth at 37 o C. Suspicion of P.marneffei infection arises when a immunocompromised individuals especially HIV positive persons present with Molluscum contagiosum like skin lesions. But p ulmonary manifestations are not characteristic of P.marneffei infection unless we t est the sputum for fungal growth in individuals wit h low CD 4 counts ,we may miss P.marneffei respiratory infection. Material and methods: 100 sputum samples from HIV patients with cough were examined for fungal pathogens by inoculating the samples on SDA and incubated at 28 o C. The samples with greenish yellow mycelial growt h with diffusible red pigment were inoculated on blood agar and SDA and incubates at 37 o C for conversion to yeast. Results: We isolated two cases of P.marneffei out of 100 samples. The CD 4 counts of the cases were 33 and 84. Conclusions: Early diagnosis and treatment reduces the mortality P.marneffei HIV patients. Streszczenie Wstep: Infekcja Penicillium marneffei jest pojawiającym sie zakaŜeniem grzybiczym w obecnym, globalnym scenariuszu pandemii HIV. P. marneffei jest dymorficznym grzybem ze wzrostem grzybni w 37 o C. Podejrzenie zakaŜenia P.marneffei powstaje, gdy u osob z
Penicillium marneffei
Dimorphic fungus
Opportunistic infection
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Penicillium marneffei is a dimorphic fungus causing infection mainly in immunocompromised individuals, especially those with HIV infection. Penicillium marneffei is an important opportunistic pathogen of HIV infection in South East Asia including Manipur. Common clinical manifestations are fever, cough, weight loss, generalised lymphadenopathy, and papulonodular eruptions. We report an unusual case of HIV patient with Penicillium marneffei infection presenting as hoarseness.
Penicillium marneffei
Dimorphic fungus
Fungal pathogen
Presentation (obstetrics)
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Penicillium marneffei
Opportunistic infection
AIDS-Related Opportunistic Infections
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Penicillium marneffei is an opportunistic pathogenic fungus emerged in recent year, which may develop serious disseminated infection in immunocompromised patients, especially HIV infected patients. At present, penicilliosis marneffei has become third common disease following tuberculosis and cryptococcosis in AIDS patients in Southeast Asia. Its mortality rate is as high as 91.3% if penicilliosis marneffei fails to be early diagnosed and treated pooperly. Therefore, early diagnosis and treatment of this disease is very important.
Penicillium marneffei
AIDS-Related Opportunistic Infections
Opportunistic infection
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Objective To evaluate the method of blood culture to isolate Penicillium marneffei from HIV patients.Methods Blood from two different parts of patients were put into two BD aerobic blood culture bottles,cultured by BD 9240 instrument.If fungal spores or hypha on the smear were found,the instrument would alarm and blood samples were initially cultured with Sabouraud agar medium and blood plate respectively at 35℃ and 25℃ When filamentous colonies formed in due course,they were cultured in two kinds of Sabouraud agar medium,and observed daily on colony morphology changes with lactic acid phenolic cotton blue staining.Results There were 6 strains of Penicillium marneffei isolated from 63 cases of HIV patients with blood culture.Conclusion HIV Patients were easily infected with Penicillium marneffei and bacteriology laboratory should be alert to run for the timely detection of Penicillium marneffe.
Penicillium marneffei
Blood Culture
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