In vitro characterization of a solvent-controlled nitroglycerin transdermal system
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Nitroglycerin (drug)
Transdermal drug delivery system was presented to overcome the difficulties of drug delivery especially oral route. A transdermal patch is a medicated adhesive patch that is placed on the skin to deliver a specific dose of medication through the skin and into the bloodstream. It promotes healing to an injured area of the body. Transdermal drugs are self-contained, discrete dosage form. It also provides controlled release of the drug for extended period of the time. Drug delivery through the skin to achieve a systemic effect without producing any fluctuations in plasma concentration of the drug. This review article covers introduction, outline advantages, disadvantages, skin pathways for transdermal drug delivery systems, various components of transdermal patches, preparation of transdermal patches, factor affecting transdermal patches, evaluation of transdermal system.
Transdermal patch
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Nitroglycerin (drug)
Methemoglobin
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乳房切断術において, 出血量減少と良好な手術視野確保の目的で, 低血圧麻酔は広く併用されている. その低血圧の導入, 維持に, ニトログリセリン (以下TNG) が多く使用されている. TNGは, in vitro で血小板凝集能を下げ, in vivo で出血時間を延長するという報告もみられる. そこで我々は, TNGによる低血圧麻酔の凝固系への影響を検討するために, 出血時間, 凝固時間, 血小板凝集能, 血小板容積分布曲線を検索した. 結果は, TNG低血圧麻酔は, これらに何の影響も与えず, 血液凝固学的にも安全であることが判明した.
Nitroglycerin (drug)
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Nitroglycerin (drug)
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Nitroglycerin (drug)
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Nitroglycerin (drug)
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Nitroglycerin (drug)
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Transdermal drug delivery system was presented to overcome the difficulties of drug delivery especially oral route. A transdermal patch is a medicated adhesive patch that is placed on the skin to deliver a specific dose of medication through the skin and into the bloodstream. It promotes healing to an injured area of the body. An advantage of a transdermal drug delivery route over other types of delivery system such as oral, topical, i.v., i.m., etc. is that the patch provides a controlled release of the medication into the patient, usually through either a porous membrane covering a reservoir of medication or through body heat melting thin layers of medication embedded in the adhesive. The main disadvantage to transdermal delivery systems stems from the fact that the skin is a very effective barrier, as a result, only medications whose molecules are small can easily penetrate the skin, so it can be delivered by this method. This review article describes the overall introduction of transdermal patches including type of transdermal patches, method of preparation of transdermal patches and factor affecting etc.
Transdermal patch
Delivery system
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