A new family of homeobox genes encoding multiple homeodomain and zinc finger motifs
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Homeobox protein Nkx-2.5
Homeobox A1
HNF1B
EMX2
Homeobox genes define a class of genes containing homeobox sequences and encoding proteins, that are identified as transcription regulator controlling cellular development and differentiation, and controlling patterns of gene expression. LIM homeobox genes contain both a homeobox and a conservative sequences (encoded LIM domain). The members of the LIM homeobox genes family which have recently been identified include lin-11, mec-3, apterous(ap), isl-1, LH-2, Rlim, lim-1, lmx-1, Xlim-1 and Xlim-3. Recent findings suggested that products expressed by LIM homeobox genes family play an important role in adjusting differentiation and developmental of the organism. The effects of LIM homeobox genes in the differentiation and development of neurons are currently attracting more and more attention.
Homeobox A1
Homeobox protein Nkx-2.5
HNF1B
DLX5
EMX2
LIM domain
CDX2
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Homeobox A1
HNF1B
Homeobox protein Nkx-2.5
DLX5
EMX2
Hindbrain
CDX2
Diencephalon
Developmental Biology
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Plant homeobox genes are an important class of transcription factor encoding genes which were involved in plant individual development.Plant homeobox genes and its encoding proteins have a highly conservative structure.Homeobox genes can be found in most plants.The homeobox proteins play important roles during plant individual development.The related research will help to reveal the developmental process of plant.The advances in research on plant homeobox genes were reviewed.
Homeobox A1
Homeobox protein Nkx-2.5
HNF1B
EMX2
DLX5
CDX2
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On the basis of the analysis of cDNA of three new homeobox-containing genes from human, chicken, and newt, a new class of homeobox genes Anf is characterized homologous to the Xanf-1 gene from Xenopus laevis, earlier cloned by us. These genes may be largely involved in the specification of embryonic subdivisions in the forebrain region of the embryo. The homeodomains of the proteins encoded by these genes differ greatly in the primary structure from all previously described homeobox genes. The high variability of the homeodomain sequences of the proteins of this class imply their rapid evolution.
Homeobox A1
Homeobox protein Nkx-2.5
HNF1B
EMX2
DLX5
Cloning (programming)
Forebrain
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There was a highly conservative homeobox in nearly all homeobox gene family,which used for encoding transcription regulatory factors(homeobox protein) and generated the accurate regulating action in cells proliferation and differentiation.The mutation of homeobox gene not only resulted in development malformation,but also had a close relationship with the occurrence and development of some tumours.The structural features of homeobox gene and the effect in tumours were summarized.
Homeobox A1
Homeobox protein Nkx-2.5
HNF1B
EMX2
DLX5
CDX2
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BACKGROUND Homeobox genes encode transcription factors involved in the genetic control of normal development and differentiation, as well as in malignant transformation. To begin to assess the possible role of homeobox genes in prostatic cell carcinogenesis, we surveyed initially for expression of homeobox-containing genes in the TSU-PR1 cell line. METHODS This was performed by RT-PCR using degenerate oligodeoxyribonucleotide primers to the homeobox-binding sequence to generate partial cDNAs which were cloned and sequenced. RESULTS Using this method, expression of 14 members of homeobox-containing genes were detected in TSU-PR1 cells. All of these expressed genes correspond to previously identified homeobox genes located within the HOXA, B, C, and D clusters. We further examined the expression of these homeobox genes in different human prostatic cell lines by using whole cDNA slot blot and Northern blot analysis. One of the sequences corresponding to the human GBX2 homeobox gene is overexpressed in TSU-PR1, LNCaP, PC-3, and DU145 metastatic prostate cell lines relative to the normal prostate. CONCLUSIONS Our results suggest that the homeobox gene GBX2 may participate in metastatic progression in prostatic cancer. © 1996 Wiley-Liss, Inc.
Homeobox A1
HNF1B
DU145
Homeobox protein Nkx-2.5
CDX2
EMX2
Northern blot
DLX5
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Homeobox A1
HNF1B
Homeobox protein Nkx-2.5
EMX2
Cloning (programming)
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Citations (27)
Homeobox A1
HNF1B
DLX5
Homeobox protein Nkx-2.5
EMX2
CDX2
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Homeobox A1
Homeobox protein Nkx-2.5
HNF1B
EMX2
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Citations (18)
Homeobox genes are regulatory genes encoding nuclear proteins that act as transcription factors, regulating aspects of morphogenesis and cell differentiation during normal embryonic development of several animals. Vertebrate homeobox genes can be divided in two subfamilies: clustered, or HOX genes, and nonclustered, or divergent, homeobox genes. During the last decades, several homeobox genes, clustered and nonclustered ones, were identified in normal tissue, in malignant cells, and in different diseases and metabolic alterations. Homeobox genes are involved in the normal teeth development and in familial teeth agenesis. Normal development and cancer have a great deal in common, as both processes involve shifts between cell proliferation and differentiation. The literature is accumulating evidences that homeobox genes play an important role in oncogenesis. Many cancers exhibit expression of or alteration in homeobox genes. Those include leukemias, colon, skin, prostate, breast and ovarian cancers, among others. This review is aimed at introducing readers to some of the homeobox family functions in normal tissues and especially in cancer.
Homeobox A1
Homeobox protein Nkx-2.5
HNF1B
DLX5
CDX2
EMX2
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Citations (107)