The relationship between circulating andorgens, obesity, and hyperinsulinemia on serum insulin-like growth factor binding protein-1 in the polycystic ovarian syndrome
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Basal (medicine)
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Pathogenesis
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Insulin-like growth factors (1GF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) play important roles in cell growth and differentiation. The aim of this work was to investigate the roles of IGF-1 and IGFBP-3 in esophageal cancer.We examined the circulating IGF-1 and IGFBP-3 concentration in 18 healthy controls and 66 esophageal cancer patients by ELISA and a ligand capture immunoassay. Immunohistochemistry for IGF-1 was performed on surgical specimens obtained from 93 patients with esophageal cancer.The serum IGF-1 and IGFBP-3 levels were significantly elevated in patients compared with healthy subjects and there was a positive correlation between IGF-1 and IGFBP-3. There was a significant correlation between IGF-1 level and depth of invasion and pathological stage. Poor prognosis was significantly correlated with increasing IGF-1 levels. The survival rates of high IGF-1 expression immunohistochemical study patients were poorer than those of low expression patients.Elevated serum IGF-1 levels may be an important predictor of risk for esophageal cancer. IGF-1 related to the progression of esophageal cancer may depend on an autocrine function of IGF-1.
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The objective of this study is to explore how hyperinsulinemia and insulin resistance relate to the clinical, endocrine and metabolic factors in the infertile women with polycystic ovary syndrome. This study was conducted on 121 consecutive infertile women with polycystic ovary syndrome attending the Infertility unit from January 2017 to December 2017. They were divided into two groups: insulin resistant and insulin sensitive. There was significant difference in body mass index and waist circumference between the two groups. Serum lipids were not associated with insulin resistance. Hyperinsulinemia was significantly associated with metabolic syndrome. Reducing body mass index and waist circumference may improve insulin resistance in infertile women with polycystic ovary syndrome. Screening the infertile women with polycystic ovary syndrome for hyperinsulinemia and insulin resistance and subsequent counseling is recommended to address the long-term risks of metabolic syndrome.
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Objective To observe the clinical efficacy of diane-35 combined with metformin in the treatment of polycystic ovary syndrome complicated with hyperinsulinemia. Methods According to the different treatments, 135 patients with polycystic ovary syndrome and hyperinsulinemia were divided into diane-35 group, metformin group, diane-35 combined with metformin group and the control group (without treatment). The level of FSH and LH, T, INS, LH/FSH ratio in each groups were observed. Results There were differences between diane-35 combined with metformin group and diane-35 group in level of FSH, LH, T, INS and LH/FSH ratio (P 0.05). Conclusions Diane-35 combined with metformin is more effective than diane-35 alone in the treatment of polycystic ovary syndrome complicated with hyperinsulinemia.
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