Model Experiments Directed towards the Synthesis of N-Aminopeptides
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Since modified peptides embodying a 1,1-disubstituted hydrazide (II) have not been described previously, model experiments were carried out to determine suitable reaction conditions for their preparation. The synthesis of model compounds of type II is the subject of this paper.This article presents an efficient method for the synthesis of 3,5-dinitrosalicyl hydrazide-15N2,with salicylic acid as the common substrate. Nitration of salicylic acid with KNO3-15N provided 3,5-dinitrosalicylic acid-15N2 and then we got 3,5-dinitrosalicyl hydrazide-15N2 by the esterification and hydrazinolysis reaction. The yield of 3,5-dinitrosalicyl hydrazide-15N2was 55. 5% based on K15NO3.The product was confirmed by NMR and LC-MS to be the target compound. Its chemical purity was 97. 3% and isotopic enrichment of15N was 99. 2%. It could be used as internal standard in the field of food safety testing.
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Isonicotinic acid
Hydrazine (antidepressant)
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The first organometallic clusters of mixed hydrazide/hydroxylamide clusters of zinc, [Zn(MeZn)(4)(HNNMe(2))(2)(ONEt(2))(4)] and {Zn(EtZn)(4)[HNN(CH(2))(5)](2)(ONEt(2))(4)} were synthesized in one-pot synthesis protocols from dialkylzinc solutions, substituted hydrazines and N,N-diethylhydroxylamine; competing for the Zn atoms, the different binding properties of hydrazide and hydroxylamide ligands in these heteroleptic clusters are discussed.
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Three steps of two novel ligands of Indomethacin hydrazide based Schiff bases ligands were synthesized. For our targeted ligands, first we synthesized Indomethacin Ethyl Ester (RCOOC 2 H 5 ), This ester was further reacted with hydrazine hydrate to produce Indomethacin acid hydrazide (RCONHNH 2 ). Finally, this hydrazide condensed with o -Vanillin and p -Vanillin to get targeted compounds. Structure confirmation was characterized based on IR, 1 H-NMR and 13 C-NMR spectroscopy. Keywords: NSIADs, Indomethacin, o -Vanillin, p- Vanillin, acid hydrazide, Hydrazone, transition metal complexes, Hydrazide Base Schiff Bases.
Hydrazone
Hydrazine (antidepressant)
Proton NMR
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Chelate formation by Cu(II) and isonicotinic acid hydrazide has been postulated as an important step in the antitubercular activity of isonicotinic hydrazide (Isoniazid). Reevaluation of the copper-isonicotinic hydrazide system gives evidence for the formation of a Cu(I) species rather than a Cu(II) species. The reduction of Cu(II) to Cu(I) and the subsequent formation of an isonicotinic hydrazide complex with the latter ion, therefore, may be the critical reaction responsible for the efficacy of isonicotinic hydrazide against Mycobacterium tuberculosis.
Isonicotinic acid
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Phthalazine
Ethyl ester
Amide
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The main aim of this research was the synthesis, spectral identification and in vitro antimicrobial evaluation of new hydrazides and hydrazide-hydrazones of 2,3-dihalogen substituted propionic acids. New hydrazides were obtained by the substitution reaction of appropriate ethyl esters of 2,3-dihalogen substituted propionic acids with hydrazine hydrate. Then obtained hydrazides were subjected to condensation reaction with various aldehydes which yielded with new hydrazide-hydrazone derivatives. All obtained compounds were identified on the basis of spectral methods (1 H-NMR, 13 C-NMR) and in vitro screened against a panel of bacterial and fungal strains according to EUCAST and CLSI guidelines.
Hydrazone
Hydrazine (antidepressant)
Proton NMR
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