Ultra-performance liquid chromatography–tandem mass spectrometry determination and depletion profile of flunixin residues in tissues after single oral administration in rabbits

The presence of the nucleoside antitumor antibiotic toyocamycin in the fermentation broth was determined by a combination of negative and positive ion fast atom bombardment (FAB) mass spectrometry, high resolution FAB mass spectrometry and mass-analysed ion kinetic energy spectrometry (MIKES). A reasonable limit of detection for toyocamycin in the whole broth was obtained by combining the specificity of mass spectrometry/mass spectrometry (also called tandem mass spectrometry) to FAB. The role played by the fermentation matrix upon the production and the observation of characteristic ions by FAB using xenon atoms was examined. High-performance liquid chromatography (HPLC) and FAB mass spectrometry were used to monitor toyocamycin at all stages of strain development, fermentation and recovery.

Fast atom bombardment

10.1002/bms.1200111206

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Citations (9)

Preparative high-performance liquid chromatographic separation and isolation of bacitracin components and their relationship to microbiological activity

Journal of Chromatography A (1992)

Robert G. Bell

Bacitracin

Chromatographic Separation

10.1016/0021-9673(92)87018-4

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Citations (22)

Identification of phase I metabolites of cardiovascular and anti-ulcer drugs in surface water samples with liquid-chromatography–mass spectrometry methods

Talanta (2011)

Renáta Varga Zsuzsanna Eke Kornél Torkos

10.1016/j.talanta.2011.07.020

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Citations (7)

Multiple stage mass spectrometry: the next generation tandem mass spectrometry experiment

The Analyst (1994)

Gary L. Glish

Tandem mass spectrometry has become a powerful tool for basic and applied mass spectrometry studies. Mass spectrometers based on ion trapping techniques, such as the quadrupole ion trap, have some unique capabilities as tandem mass spectrometers. Of particular note are the high MS–MS efficiency, the ability to perform multiple stages of tandem spectrometry (MSn), and the ability to effect ion–molecule reactions as part of the experimental sequence. This paper discusses the MSn experiment in a quadrupole ion trap and provides several examples of MSn experiments in which ion–molecule reactions are incorporated as one or more steps in the experiment. Examples include one in which MSn is used to determine the structure of an ion–molecule reaction product, one that involves multiple stages of collision-induced dissociation to generate a 13C containing reactant ion for an isotopic study, and one in which ion–molecule reactions are used to differentiate isomeric ion structures.

Top-down proteomics

Collision-induced dissociation

Tandem

Hybrid mass spectrometer

Quadrupole ion trap

Ion-mobility spectrometry–mass spectrometry

10.1039/an9941900533

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Citations (14)