Antioxidative Activity of the Hydrolytic Enzyme Treated Sorbus commixta Hedl. and its Inhibitory Effect on Matrix Metallopro- teinase- 1 in UV Irradiated Human Dermal Fibroblasts
28
Citation
34
Reference
10
Related Paper
Citation Trend
Keywords:
Matrix (chemical analysis)
Human skin
The electrical responses of 25 cells suggested to be hippocampal inhibitory interneurons to stimulation of two afferent fibre systems originated in contralateral hippocampus were investigated in nonanesthetized curarized rabbits. It is stated that the neurons under study have not only high-effective excitatory input but also a weak inhibitory one. The background and evoked activities of the neurons were under predominating influence of the excitatory input which plays a determining role in their behaviour.
Cite
Citations (3)
Human skin
Photoacoustic Spectroscopy
Ex vivo
Cite
Citations (2)
The effect of isoflurane on inhibitory postsynaptic potentials (IPSPs) was studied in rat hippocampal slices by intracellular recordings from pyramidal neurons (n = 34). The amplitude of the IPSP was transiently increased and subsequently reduced in a dose-dependent manner. The duration of the IPSP was increased. The reduction in the IPSP persisted after correction was made for the anesthetic-induced hyperpolarization. The reversal potential for the IPSP was slightly displaced in the depolarizing direction. The depolarizing γ-aminobutyric acid (GABA) response was unaltered, while the hyperpolarizing GABA response was reduced, suggesting a postsynaptic action. The reduction in the IPSP produced by isoflurane is at least partly due to an altered reversal potential for the IPSP (EIPSP).
Cite
Citations (3)
Cite
Citations (0)
Cite
Citations (0)
Human skin
Skin equivalent
Cite
Citations (35)
In computational neural network models, neurons are usually allowed to excite some and inhibit other neurons, depending on the weight of their synaptic connections. The traditional way to transform such networks into networks that obey Dale's law (i.e., a neuron can either excite or inhibit) is to accompany each excitatory neuron with an inhibitory one through which inhibitory signals are mediated. However, this requires an equal number of excitatory and inhibitory neurons, whereas a realistic number of inhibitory neurons is much smaller. In this letter, we propose a model of nonlinear interaction of inhibitory synapses on dendritic compartments of excitatory neurons that allows the excitatory neurons to mediate inhibitory signals through a subset of the inhibitory population. With this construction, the number of required inhibitory neurons can be reduced tremendously.
Cite
Citations (0)
Cite
Citations (9)
P92 steel was irradiated with Ar ion up to 10 dpa at 200, 400, and 700 °C. The effect of Ar ion irradiation on hardness was investigated with nanoindentation tests and microstructure analyses. It was observed that irradiation-induced hardening occurred in the steel after Ar ion irradiation at all three temperatures to 10 dpa. The steel exhibited significant hardening at 200 and 700 °C, and slight hardening at 400 °C under Ar ion irradiation. Difference in the magnitude of irradiation-induced hardening at different temperature in the steel is attributed to different changes in the microstructure of the steel that arose from the irradiation. Irradiation-induced hardening in the P92 steel irradiated at 200 °C is attributed to the occurrence of both dislocation loops and other fine irradiation defects during irradiation. Slight hardening in the steel irradiated at 400 °C mainly arises from the annihilation of defect clusters at this temperature. The occurrence of fine Ar bubbles with high number density during the Ar ion irradiation at 700 °C resulted in the significant hardening in the steel.
Hardening (computing)
Cite
Citations (9)
The most typical and well known inhibitory action in the cortical microcircuit is a strong inhibition on the target neuron by axo-somatic synapses. However, it has become clear that synaptic inhibition in the cortex is much more diverse and complicated. Firstly, at least ten or more inhibitory non-pyramidal cell subtypes engage in diverse inhibitory functions to produce the elaborate activity characteristic of the different cortical states. Each distinct non-pyramidal cell subtype has its own independent inhibitory function. Secondly, the inhibitory synapses innervate different neuronal domains, such as axons, spines, dendrites and soma, and their IPSP size is not uniform. Thus cortical inhibition is highly complex, with a wide variety of anatomical and physiological modes. Moreover, the functional significance of the various inhibitory synapse innervation styles and their unique structural dynamic behaviors differ from those of excitatory synapses. In this review, we summarize our current understanding of the inhibitory mechanisms of the cortical microcircuit.
Pyramidal cell
Dendritic spike
Cite
Citations (161)