Interaction of the putative dopamine autoreceptor agonists 3-PPP and TL-99 with [3H]apomorphine binding sites in rat striatal membranes

The effects of domperidone, a peripheral dopamine receptor blocker which poorly crosses the blood‐brain barrier, on copulatory and exploratory behaviour were studied in apomorphine (oestrogen + progesterone) treated ovariectomized rats. The dose of domperidone (1.0 mg/kg) which clearly prevented the inhibitory action of apomorphine on the lordotic response did not influence the effect of apomorphine in an exploratory test situation. This finding indicates that peripherally (intraperitoneally) administered domperidone influences dopaminergic mechanisms implicated in the copulatory behaviour of the female rat, but not dopaminergic mechanisms involved in exploratory behaviour. The possibility that domperidone reaches the brain region responsible for the lordotic behaviour, e.g. the hypothalamus, is discussed.

Domperidone

Apomorphine

10.1111/bcpt.1985.57.3.160

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Citations (7)

Blockade of apomorphine-induced yawning in rats by the dopamine autoreceptor antagonist (+)-AJ 76

Neuropharmacology (1989)

Colin T. Dourish Erik G. Herbert Susan D. Iversen

Apomorphine

Autoreceptor

Dopamine antagonist

10.1016/0028-3908(89)90021-x

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Citations (13)

S.01.01 Antipsychotic effect of four different compounds — results of the metatrial

European Neuropsychopharmacology (2003)

W. Rein Lisa A. Arvanitis

Apomorphine

Autoreceptor

Dopamine antagonist

10.1016/s0924-977x(03)91598-7

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Citations (6)

Differential action of domperidone to modify emesis and behaviour induced by apomorphine in the ferret

European Journal of Pharmacology (2005)

Angie Lau Man-P. Ngan John A. Rudd David T. Yew

Domperidone

Apomorphine

Licking

10.1016/j.ejphar.2005.05.028

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Citations (16)

Assessment of dopamine autoreceptor agonist properties of apomorphine, (+)-3-PPP and (−)-3-PPP by recording of yawning behaviour in rats

European Journal of Pharmacology (1984)

Lars Ståhle Urban Ungerstedt

Apomorphine

Autoreceptor

Sniffing

Sulpiride

10.1016/0014-2999(84)90608-3

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Citations (71)

Modification by domperidone of dopamine‐ and apomorphine ‐ induced inhibition of extrinsic ruminal contractions in goats

Journal of Veterinary Pharmacology and Therapeutics (1982)

Chris L. Maas C. T. M. van Duin A. S. J. P. A. M. van Miert

Goat ruminal strips reacted with an increase in smooth muscle tone after exposure to apomorphine. This rise in tone could be blocked by domperidone, but not by naltrexone. In vivo , both dopamine and apomorphine caused inhibition of extrinsic ruminal contractions. These effects were completely prevented by domperidone pretreatment, whereas naltrexone was not an effective antagonist. These results suggest that apomorphine‐induced inhibition of rumen motility is due to DA‐receptor activation. The exact location of these DA‐receptors remains to be determined.

Domperidone

Apomorphine

Dopamine antagonist

10.1111/j.1365-2885.1982.tb00430.x

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Citations (22)

Inhibition of Dopa-production in Striatal Synaptosomes by the R(−) and the S(+) Enantiomers of Apomorphine

Palgrave Macmillan UK eBooks (1986)

Matthias Bräutigam B. Kittner Gabriele Laschinski

Apomorphine

Autoreceptor

10.1007/978-1-349-07431-0_64