Cytokines: interleukin and interferon therapy in dermatology
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Journal Article Cytokines: interleukin and interferon therapy in dermatology Get access K. Asadullah, K. Asadullah Schering AG, Berlin, Germany, and K. Asadullah, Schering AG, D‐13342 Berlin, Germany. E‐mail: khusru.asadullah@schering.de Search for other works by this author on: Oxford Academic Google Scholar W. Sterry, W. Sterry Department of Dermatology and Allergy, University Hospital Charité, Berlin Humboldt University, Germany Search for other works by this author on: Oxford Academic Google Scholar U. Trefzer U. Trefzer Department of Dermatology and Allergy, University Hospital Charité, Berlin Humboldt University, Germany Search for other works by this author on: Oxford Academic Google Scholar Clinical and Experimental Dermatology, Volume 27, Issue 7, 1 October 2002, Pages 578–584, https://doi.org/10.1046/j.1365-2230.2002.01144.x Published: 01 October 2002 Article history Accepted: 17 June 2002 Published: 01 October 2002STAT1
Interferon alfa
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Drug ingestion may play an important role in the induction and exacerbation of psoriasis. Drugs may directly induce the occurrence of psoriasis in susceptible individuals, or cause the recurrence or exacerbation of preexisting psoriasis. In view of their relationship with psoriasis, drugs can be classified as follows: drugs that are definitely able to induce or exacerbate psoriasis (e.g., lithium), and drugs that are possible to induce or exacerbate psoriasis (e.g., interferon). Clinical and histological studies on drug-induced or-exacerbated psoriasis are helpful to investigate into the pathogenesis of psoriasis. Further studies are still needed for drugs that are possible to induce or exacerbate psoriasis, which may be of great importance for the prevention of psoriasis in susceptible individuals.
Key words:
Psoriasis; Pharmaceutical preparations; Lithium compounds; Antimalarials; Biological agents; Provoke; Exacerbate
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Objective To Investigate whether the PDEs activities is abnormal or not in psoriasis patients by detecting the PDEs activities of both psoriasis patients and healthy controls, and explore the potential role of PDEs activities changes in the pathogenesis of psoriasis. Methods PDEs activities were detected by using high performance liquid chromatography(HPLC) in 50 patients with psoriasis and 60 healthy controls. Results The PDEs activities is 10.40%±3.54% in psoriasis patients,and 8.60%±2.25% in the healthy controls. The PDEs activities in patients with psoriasis is significant higher than that in the controls (P0.05). Conclusions The PDEs activities may be a risk factor for psoriasis.
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【Objectives】 To test the expression levels of soluble CD147(sCD147) in plasma of psoriasis vulgaris(PV) patients and normal controls. Describe disease severity of PV with psoriasis lesion degree score(PASI) and analyze the correlation between the expression levels of sCD147 in psoriasis patients and disease severity. To test the expression levels of sCD147 in plasma of different subtypes of psoriasis patients, and study the roles of sCD147 play in the psoriasis classification. 【Methods】 Detect the expression levels of sCD147 in 74 PV patients and 41 normal controls by enzyme-linked immunosorbent assay(ELISA). Analyze the correlation between sCD147 expression levels and PASI score. Detect the expression levels of sCD147 of plasma in 10 patients with psoriasis pustulose(PP), 12 patients with arthritis psoriasis(PsA) and 7 patients with psoriasis erythrodermic(PE). Statistical analyze the difference of sCD147 expression levels in patients with different subtypes of psoriasis. 【Results】 The sCD147 expression levels in plasma of PV patients were significantly higher than those in normal controls(Ctrl)(P 0.01). Statistical analysis showed that there was no correlation between sCD147 expression level and PASI score(r =0.123, P =0.298). There was significant difference of sCD147 expression levels in different subtypes of psoriasis patients(PV PP PsA PE)(P 0.001). 【Conclusion】The expression levels of sCD147 is significantly increased in psoriasis patients. There is statistical significance of sCD147 expression levels in four subtypes of psoriasis. Thus, sCD147 may become a new target for psoriasis drug treatment.
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The interferon-specific cellular receptors in human cells cultures differing in sensitivity to alpha-interferon have been studied. The J-41 cells resistant to alpha-interferon are practically devoid of receptors highly specific to alpha-interferon. The coefficient of equilibrium and the number of receptors analyzed after Scatchard for J-96 culture of cells are 15.6 x 10(11) M-1 and 210 +/- 90, respectively. Evidently, resistance of J-41 cells to alpha-interferon is connected with the absence of interferon receptors and, as a consequence, inability to interferon-receptor interaction.
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Interferon type I
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Introduction: T-helper 1 (Th1), Th17 cells, and their related cytokines are implicated in psoriasis pathogenesis although the contribution of each group of cytokines in psoriasis activity has not been fully clarified. Objectives: To investigate whether Th17-related cytokines are associated with psoriasis activity. Methods: The serum levels of interleukin (IL)-1β, 6, 8, 17Α, 22, 23, and tumor necrosis factor-α (TNFα) were measured with flow cytometry in 35 patients with plaque psoriasis (21 with stable and 14 with active disease) and in 20 healthy controls. Results: Interleukin-6, 8, 17A, 22, 23, and TNFα were significantly elevated in psoriasis patients compared with controls. In the sensitivity analyses, patients with active disease showed significantly increased levels of IL-17A, IL-23, and IL-22 as compared to the group of patients with stable psoriasis. Conclusions: Our study highlights a possible crucial role of IL-17A, IL-22, and IL-23 in the activity of psoriasis and the early stages of the disease.
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Interleukin-23
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This chapter contains sections titled: Introduction History of psoriasis Who gets psoriasis? Biology of psoriasis Comorbidities associated with psoriasis Clinical variants of psoriasis Physical symptoms that accompany psoriasis Trigger factors in psoriasis Treatments for psoriasis Measuring quality of life Conclusion References
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