ICAM-2 confers a non-metastatic phenotype in neuroblastoma cells by interaction with α-actinin
Joseph M. FeduskaStephen G. AllerPatrick L. GarciaS L CramerLeona N. CouncilRobert C.A.M. van WaardenburgKarina J. Yoon
15
Citation
46
Reference
10
Related Paper
Citation Trend
Keywords:
Actinin
Cite
Citations (9)
Intercellular adhesion molecule
Cite
Citations (0)
Objective: To investigate PYM-regulated expressions of VCAM-1,ICAM-1 and ICAM-3 in primary cultured HVMECs.Methods: Expressions of the adhesion molecules VCAM-1,ICAM-1 and ICAM-3 were studied in PYM-regulated HVMECs in vitro by means of ELISA and RT-PCR.Results: Expressions of VCAM-1 and ICAM-3 were induced,and expression of ICAM-1 was up-regulated,both in a time and concentration-dependent fashion after stimulation with PYM.The expression of VCAM-1 was observed at 2h and ICAM-1 at 6h and ICAM-3 at 12h.The highest expression of VCAM-1,ICAM-1 and ICAM-3 was observed at 8h,18h and 24h.After exposed for the same time interval,expression of adhesion molecules on HVMECs exposed to 1mg/L of PYM was higher than that exposed to other concentration of PYM.mRNA expressions of VCAM-1,ICAM-1 and ICAM-3 started at 2h,6h and 12h respectively.Maximal synthetic activity was observed at 6-8h for VCAM-1,at 12-18h for ICAM-1 and at 18-24h for ICAM-3.Synthesis activity was greatly suppressed at 10mg/L or higher concentration.Conclusion: Expression of Ig-like adhesion molecules in HVMECs can be induced or up-regulated by lower concentration of PYM in a time and concentration-dependent fashion.
VCAM-1
Intercellular adhesion molecule
Cite
Citations (0)
Microangiopathy
Intercellular adhesion molecule
Cite
Citations (0)
Intercellular adhesion molecule
Cite
Citations (2)
Cite
Citations (4)
Intercellular adhesion molecule
Cite
Citations (0)
Intercellular adhesion molecule
Cite
Citations (0)
Renal glomerulus
Glomerular hyperfiltration
Cite
Citations (48)