Serum matrix metalloproteinase‐3 concentration is influenced by MMP‐3 −1612 5A/6A promoter genotype and associated with myocardial infarction
Ann SamnegårdAngela SilveiraPia LundmanSusanna BoquistJacob OdebergJ. HultheWilliam L. McPheatPer TornvallL. BergstrandChrister EricssonAnders HamstenPer Eriksson
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Abstract. Objectives. Matrix metalloproteinase‐3 (MMP‐3) is implicated in the formation of atherosclerotic plaques, and the MMP‐3 −1612 5A/6A polymorphism is associated with myocardial infarction (MI) and stable coronary artery disease (CAD). The present study examined whether the −1612 5A/6A polymorphism in the promoter region of the MMP‐3 gene influences serum concentrations of MMP‐3 and whether serum concentrations of MMP‐3 are related to extent of coronary atherosclerosis and risk of MI. Design and subjects. This case–control study was conducted in three hospitals in the northern part of Stockholm. A total of 755 MI patients aged below 60 were screened, 433 entered and 387 completed the study. Three hundred and eighty‐seven sex‐ and age‐matched control subjects were recruited from the general population of the same county. Methods. The MMP‐3 genotype was determined by Pyrosequencing TM and the serum MMP‐3 concentration was quantified with an immunoassay. Severity and extension of CAD was assessed by quantitative coronary angiography in a subgroup of patients ( n = 243). Results. Patients had lower serum MMP‐3 concentration than controls. There was a strong association between MMP‐3 −1612 5A/6A genotype and serum concentrations of MMP‐3. The presence of one or two copies of the 6A‐allele was associated with a graded increase in serum MMP‐3. In female patients there was an inverse correlation ( r = −0.39, P < 0.05) between serum MMP‐3 concentration and plaque area. Conclusion. In conclusion, the serum concentration of MMP‐3 is influenced by MMP‐3 −1612 5A/6A genotype and associated with MI.Keywords:
Coronary atherosclerosis
Matrix metalloproteinase 9
Matrix metalloproteinases (MMPs) are also known as matrixins.Many diseases,such as osteoarthritis,multiple sclerosis,and cancer,are accompanied by changes of activity of MMPs.MMPs play roles in invasion and metastasis of malignant tumors.This article reviews the status and development on relationship between MMP-2,MMP-9 and the occurrence and metastasis of lung cancer.
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Matrix metalloproteinases; Lung cancer; Matrix metalloproteinase-2; Matrix metalloproteinase-9
Matrix metalloproteinase 9
Matrix (chemical analysis)
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The aim of the research. To assess the influence of polymorphisms of the matrix metalloproteinase genes — 2 (rs2285053), — 3 (rs3025058) , and — 13 (rs2252070) on the development of coronary atherosclerosis in patients with primary osteoarthritis. Materials and methods. The polymorphisms of the Thе pоlymоrphisms оf thе matrix metalloproteinase genes — 2 (rs2285053), — 3 (rs3025058) , and — 13 (rs2252070) and their connection with development of atherosclerosis in patients with osteoarthritis were determined. Results. In the process of studying the polymorphism (rs2252070 T/C) of the MMP — 13 gene, it was revealed that the carriage of the homozygous T allele of the MMP-13 gene polymorphism is 1,8 times higher in the group of patients without verified coronary atherosclerosis in comparison with a group of patients with verified coronary atherosclerosis. This fact shows that this genotypic variant is protective in relation to the development of atherosclerotic lesions of the coronary vessels. The heterozygous variant of the T/C genotype was more common in the group of patients with verified coronay atherosclerosis — 59%. The calculation of the odds ratio shows that the possibility of developing coronary atherosclerosis in patients with this genotype is 2,7 times higher than in patients with a homozygous grnotypic variant. Conclusion. It is shown that the heterozygous variant of rs2252070 T/C matrix metalloproteinase 13 increases the chance of developing coronary atherosclerosis in patients with osteoarthritis.
Coronary atherosclerosis
Matrix metalloproteinase 9
Matrix Metalloproteinase 3
Gene polymorphism
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Membrane-type matrix metalloproteinases (MT-MMPs) form a subgroup of the matrix metalloproteinase (MMP) family, and there are 6 MT-MMPs in humans. MT-MMPs are further sub-classified into type I transmembrane-type (MT1, − MT2-, MT3- and MT5-MMPs) and glycosylphosphatidylinositol (GPI)-anchored type (MT4- and MT6-MMPs). In either case MT-MMPs are tethered to the plasma membrane, and this cell surface expression provides those enzymes with unique functionalities affecting various cellular behaviours. Among the 6 MT-MMPs, MT1-MMP is the most investigated enzyme and many of its roles and regulations have been revealed to date, but the potential roles and regulatory mechanisms of other MT-MMPs are gradually getting clearer as well. Further investigations of MT-MMPs are likely to reveal novel pathophysiological mechanisms and potential therapeutic strategies for different diseases in the future.
Matrix (chemical analysis)
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Matrix metalloproteinase 9
Matrix metalloproteinase inhibitor
Matrix Metalloproteinase 3
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The aim of the research. To assess the influence of polymorphisms of the matrix metalloproteinase genes — 2 (rs2285053), — 3 (rs3025058) , and — 13 (rs2252070) on the development of coronary atherosclerosis in patients with primary osteoarthritis. Materials and methods. The polymorphisms of the Thе pоlymоrphisms оf thе matrix metalloproteinase genes — 2 (rs2285053), — 3 (rs3025058) , and — 13 (rs2252070) and their connection with development of atherosclerosis in patients with osteoarthritis were determined. Results. In the process of studying the polymorphism (rs2252070 T/C) of the MMP — 13 gene, it was revealed that the carriage of the homozygous T allele of the MMP-13 gene polymorphism is 1,8 times higher in the group of patients without verified coronary atherosclerosis in comparison with a group of patients with verified coronary atherosclerosis. This fact shows that this genotypic variant is protective in relation to the development of atherosclerotic lesions of the coronary vessels. The heterozygous variant of the T/C genotype was more common in the group of patients with verified coronay atherosclerosis — 59%. The calculation of the odds ratio shows that the possibility of developing coronary atherosclerosis in patients with this genotype is 2,7 times higher than in patients with a homozygous grnotypic variant. Conclusion. It is shown that the heterozygous variant of rs2252070 T/C matrix metalloproteinase 13 increases the chance of developing coronary atherosclerosis in patients with osteoarthritis.
Coronary atherosclerosis
Matrix metalloproteinase 9
Matrix Metalloproteinase 3
Gene polymorphism
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Matrix (chemical analysis)
Type IV collagen
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Matrix metalloproteinases (MMPs) are a group of zinc-dependent proteolytic enzymes able to cleave all major protein components in the extracellular matrix during the processes of wound healing and tumor formation. Tissue inhibitors of MMPs (TIMPs) , which exist in the human body, can regulate the activity of MMPs. According to different sources, MMP inhibitors are divided into TIMPs, natural MMP inhibitors and synthetic inhibitors. The classification and functional features of MMPs and MMP inhibitors are summarized and the relationship between MMPs, MMP inhibitors and posterior capsular opacification (PCO) are reviewed.
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Matrix metalloproteinases; Matrix metalloproteinase inhibitors; Cataract, secondary
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Proteolytic enzymes
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Coronary atherosclerosis
Coronary arteries
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