BNP and NT-proBNP as prognostic markers in persons with chronic stable heart failure
Mark OremusAndrew Don-WauchopeRobert S. McKelviePasqualina SantaguidaStephen HillCynthia BalionRonald A. BoothJudy BrownUsman AliAmy BustamamNazmul SohelParminder Raina
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Objective To evaluate diagnostic value of plasma brain natriuretic peptide(BNP) in patients with congestive heart failure(CHF).Methods 85 patients with acute dyspnea and whose B-type natriuretic peptide was measured with ELISA assay.The clinical diagnosis of congestive heart failure was adjudicated by two independent cardiologists,who were blinded to the results of the B-type natriuretic peptide assay.Thirty patients with normal ventricular function served as control group.Results The plasma BNP concentrations of CHF were significantly higher than that of non-CHF(P0.001 respectively),A plasma BNP concentration exceeding mean of the controls(x+1.96s) had a sensitivity of 96% and a specificity of 93% for diagnosis of congestive heart failure in patients with acute dyspnea.Conclusions Used in conjunction with other clinical information, measurement of B-type natriuretic peptide is useful in establishing or excluding the diagnosis of congestive heart failure in patients with acute dyspnea.
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Introduction Information retrieval for systematic reviews (SRs) should include sensitive searches in several bibliographic databases. In addition to standard databases (i.e., MEDLINE, Embase and CENTRAL), researchers might consider subject-specific ones. In the fields of nursing and midwifery, a SR would typically include CINAHL as a subject-specific database. The aim of this study was to analyze the number and relevance of references retrieved from CINAHL in six SRs on maternal care. Methods We conducted a retrospective analysis of six SRs (e.g., benefit of intrapartum ultrasound or one-to-one care during labor). The study type was limited to randomized controlled trials (RCTs) in all but three SRs. In all cases, MEDLINE, Embase, CENTRAL and CINAHL were searched for primary studies. Further information sources (e.g., study registries and reference lists of SRs) were also considered. The proportion of the additional number of hits and studies included from CINAHL as well as the corresponding number of participants were calculated. Results Overall, the reviewers screened 12,013 references from bibliographic databases and identified forty relevant studies. CINAHL contained 2,643 (22 percent) of the references. In five out of six SRs, no additional studies were identified in CINAHL. In the remaining SR on birthing positions, the reviewers included thirteen RCTs of which one was a feasibility study with 68 participants indexed only in CINAHL. This corresponds to 0.9 percent of the women participating in all thirteen RCTs (n = 7,861). However, this study was cited in a journal article on a subsequent RCT that was identified and included via MEDLINE and ClinicalTrials.gov. Conclusions It is not necessary to search CINAHL in SRs on maternal care if standard databases and further information sources are considered. An additional study from CINAHL was included in one out of six SRs, a small feasibility study that could have been identified without CINAHL via a subsequent RCT.
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What is heart failure? what causes heart failure? the public health problem of heart failure pathophysiology of the heart failure syndrome the symptoms and signs of heart failure investigation of the patient with heart failure treatment of heart failure - diuretics treatment for heart failure - ace inhibitors treatment of heart failure - digoxin management of heart failure - non-pharmacological therapy management of concomitant problems in patients with heart failure patients who do not respond to treatment preventions of heart failure.
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B-type natriuretic peptide is released from the cardiac ventricles in response to increased wall tension.
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Congestive Heart Failure: Trends in Epidemiology and Therapy Heart Failure and Sudden Cardiac Death Resuscitation Issues in Patients with Severe Congestive Heart Failure Pulmonary Abnormalities in Congestive Heart Failure: A Therapeutic Opportunity? Exercise Gas Exchange in Heart Failure: A Brief Review Exercise Capacity and Prognosis in Congestive Heart Failure Assessment of Physical Activity in the Patient with Heart Failure Pharmacological Enhancement of the Exercise Performance of Patients with Heart Failure Evaluating Quality of Life in Congestive Heart Failure: Issues, Progress and Recommendations Social Support and Congestive Heart Failure Patients Depression in Heart Failure Patients Sexual Functioning in Congestive Heart Failure Patients Clinical Practice Guidelines for Outpatient Management of Patients with Left Ventricular Systolic Dysfunction
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The cumulative index to Nursing and Allied Health Literature (CINAHL) is a useful research tool for accessing articles of interest to nurses and health care professionals. More than 2,800 journals are indexed by CINAHL and can be searched easily using assigned subject headings. Detailed instructions about conducting, combining, and saving searches in CINAHL are provided in this article. Establishing an account at EBSCO further allows a nurse to save references and searches and to receive e-mail alerts when new articles on a topic of interest are published.
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Objective To discuss the clinical effect of heart failure mixture in congestive heart failure.Methods Retrospective analysed clinical data of 30 cases patients with congestive heart failure accepted the treatment of heart failure mixture,and evaluated its efficacy.Results The original Western Medicine following the service on 21 cases of heart failure count not control,plus service with heart failure mixture,all effective;Nine cases with Western,the simple used of heart failure mixture,effective 7 cases,invalid 2 cases.Conclusion Heart failure mixture in congestive heart failure has significant clinical effect,without obvious adverse reaction.
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Abstract Background Results of new studies should be interpreted in the context of what is already known to compare results and build the state of the science. This systematic review and meta-analysis aimed to identify and synthesise results from meta-research studies examining if original studies within health use systematic reviews to place their results in the context of earlier, similar studies. Methods We searched MEDLINE (OVID), EMBASE (OVID), and the Cochrane Methodology Register for meta-research studies reporting the use of systematic reviews to place results of original clinical studies in the context of existing studies. The primary outcome was the percentage of original studies included in the meta-research studies using systematic reviews or meta-analyses placing new results in the context of existing studies. Two reviewers independently performed screening and data extraction. Data were synthesised using narrative synthesis and a random-effects meta-analysis was performed to estimate the mean proportion of original studies placing their results in the context of earlier studies. The protocol was registered in Open Science Framework. Results We included 15 meta-research studies, representing 1724 original studies. The mean percentage of original studies within these meta-research studies placing their results in the context of existing studies was 30.7% (95% CI [23.8%, 37.6%], I 2 =87.4%). Only one of the meta-research studies integrated results in a meta-analysis, while four integrated their results within a systematic review; the remaining cited or referred to a systematic review. The results of this systematic review are characterised by a high degree of heterogeneity and should be interpreted cautiously. Conclusion Our systematic review demonstrates a low rate of and great variability in using systematic reviews to place new results in the context of existing studies. On average, one third of the original studies contextualised their results. Improvement is still needed in researchers’ use of prior research systematically and transparently—also known as the use of an evidence-based research approach, to contribute to the accumulation of new evidence on which future studies should be based. Systematic review registration Open Science registration number https://osf.io/8gkzu/
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This paper compares the journal coverage of the British Nursing Index (BNI) and the Cumulative Index to Nursing and Allied Health Literature (CINAHL). The main objectives are to assess whether BNI is a useful source of UK publications and to consider the implications for information professionals.Lists of the journals indexed in BNI and CINAHL, CINAHL Plus and CINAHL Complete were compared. The date coverage and article entry date of a selection of UK nursing journals were also compared.One hundred and fifty-nine journals are uniquely indexed in BNI compared with the basic version of CINAHL. Eighty-one journals are uniquely indexed in BNI compared with all versions of CINAHL. Fifty-one of these journals are UK publications. Most of the selected UK nursing journals have earlier start and entry dates in CINAHL than BNI.BNI is smaller than CINAHL, and BNI indexes a relatively small number of unique journals. An information professional with access to CINAHL Plus or CINAHL Complete could reasonably not search BNI for a nursing topic, particularly if the topic is not UK specific. UK nursing research is more likely to benefit from using BNI, although the acquisition of BNI by ProQuest could impact this finding.
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Background: Pediatric acute heart failure is now being increasingly recognized as an important source of healthcare resource utilization. B-type natriuretic peptide (BNP) continues to be the dominant biomarker in pediatric heart failure. This study aimed to prove the role of BNP in diagnosis and prognosis of congestive heart failure in children. Method: This case control study was performed in Zagazig University Hospitals and include 60 infants and children who divided into 2 groups, group 1 consists of 30 children diagnosed by congestive heart failure and group 2 consists of 30 age and sex-matched apparently healthy children. Serum BNP level measured for both groups with assessment to the cardiac function, CBC, CRP and serum creatin level. Result: BNP and is significantly higher among CHF patients compared to controls. BNP is found to be higher in patients with sever heart failure compared to moderate and mild HF patients with significance correlation. BNP is found to be higher among congestive heart disease patients with sensitivity 93.3% and specificity 76%. BNP is a significant independent diagnostic parameter for CHF. BNP is found to be non-significant prognostic factors for children with CHF. Conclusion: BNP continues to be the dominant biomarker in pediatric heart failure. BNP is a significant diagnostic marker in diagnosis of heart failure, while it found to be non-significant prognostic factor in CHF.
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