Interferon-αα treatment decreases serum cross-linked C-terminal telopeptide of type I collagen in haematological diseases
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Interferon-α (IFN-α) is used in the treatment of many haematological diseases and it is known that IFN-α may affect bone turnover. The effect of IFN-α on bone metabolism was studied in 10 haematological patients. The mean duration of the treatment was 4 (range: 2.8–7.2) months. Besides the usual markers of bone metabolism, levels of the cross-linked C-terminal telopeptide of type I collagen (ICTP), the N-terminal propeptide of type I procollagen (PINP) and the bone-specific alkaline phosphatase were measured. The bone mineral density was measured by computed tomography. During IFN-α treatment, serum ICTP decreased from a mean of 5.4 (range: 1.8–12.4) to 3.6 (range: 1.4–8.8) μg/l (P= 0.017). All other variables reflecting bone metabolism remained unaltered during IFN-α treatment. The bone mineral density remained unchanged. It was concluded that the observed decrease in ICTP may be an indicator of a beneficial therapeutic effect of IFN-α on bone turnover, resulting in decreased bone resorption. However, it is possible that elevated pretreatment ICTP values reflected disease of the bone marrow.Keywords:
N-terminal telopeptide
Type I collagen
Hematology
Type I collagen is the main type found in mineralized bone. Specific radioimmunoassay for the cross-linked carboxyterminal telopeptide of type I collagen allows assessing the degradation of type I collagen in serum samples. The aim of the present investigation was to determine the concentration of cross-linked carboxyterminal telopeptide of type I collagen in serum of dietary calcium and vitamin D-deficient rats, a good model disease of decreased formation and mineralization of bone matrix and excessive bone resorption. The studies were carried out on 20 young growing Wistar rats. Serum concentration of the cross-linked carboxyterminal telopeptide of type I collagen was analyzed by the Rat Telopeptide [125I]ICTP Radioimmunoassay Kit obtained from Orion Diagnostica (Finland). The data obtained from biochemical analysis showed increased concentration of the cross-linked carboxyterminal telopeptide of type I collagen in the serum of rats fed a low calcium and vitamin D-deficient diet after 14 days of the experiment. At the end of the experiment (day 21), the concentration of carboxyterminal telopeptide of type I collagen in serum was still elevated in these animals. In conclusion, dietary calcium and vitamin D-deficiency in rats produces hypocalcaemia together with the increased concentration of the cross-linked carboxyterminal telopeptide of type I collagen in serum.
N-terminal telopeptide
Type I collagen
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Carboxyterminal propeptide of type I collagen (P1CP) and cross-linked carboxyterminal telopeptide of type I collagen (1CTP) are known as parameters of bone metastasis in patients with prostate cancer (PCa). We measured the serum P1CP and 1CTP levels in 52 PCa patients and evaluated the clinical usefulness of these serum markers. Both serum levels of P1CP and 1CTP were significantly higher in patients with extent of disease (EOD) grade 2 or 3 bone metastases than in patients without bone metastasis. Thus, P1CP and 1CTP are not as useful at first detection of bone metastases as bone scintigram. On the other hand, in the patients who indicated high serum levels of P1CP or 1CTP before initial treatment, the changes in the concentrations of these markers may be helpful in evaluating the response to treatment or the progression of disease. Our results suggest that P1CP and 1CTP are useful markers for monitoring the metastatic burden in the bone of PCa patients, but the efficacy is limited in high EOD grade cases.
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Type I collagen
Protein precursor
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To reassess the clinical utility of serum pyridinoline cross-linked carboxyterminal telopeptide of type I collagen (ICTP), a promising but controversial indicator of bone resorption, we evaluated its performance as a biochemical marker in a 6-month study of a strictly selected population of 76 Japanese postmenopausal and healthy women, 33 recipients of hormone replacement therapy and 43 nonrecipients. We measured bone mineral density (BMD) of the lumbar spine (L2-L4), and serum ICTP, carboxyterminal propeptide of type I procollagen (PICP) and other conventional serum biochemical markers, e.g. bone gla protein (BGP), alkaline phosphatase, calcium and phosphate at the entry and 6 months later. We calculated the percent change between the baseline and 6-month values (delta%) in lumbar BMD and the biochemical markers, individually, and compared the degree of correlations between delta% in BMD and that in the biochemical markers. Delta% in ICTP and delta% in BGP correlated with delta% in BMD negatively and significantly. Especially delta% in ICTP correlated with that in BMD to a high degree (P<0.0001). No significant correlation was observed in other biochemical markers. We concluded that serum ICTP is a sensitive and useful bone resorption marker in the postmenopausal population, which strongly correlates with the change in BMD.
N-terminal telopeptide
Pyridinoline
Type I collagen
Bone remodeling
Procollagen peptidase
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Serum levels of carboxyterminal telopeptide of type I collagen (ICTP), a marker of matrix degradation, were measured by RIA test, on 184 samples of healthy newborns and children aging from 1 (cord blood) to 90 days of life. We found ICTP values about tenfold higher than the adults', with highly significant variations (P < 0.001) in the whole period studied. During the first three months of life serum levels of the bone marker show a progressive increase from 0 to 7 days, they remain unchanged until the 30th day and then decrease until the 45th day, maintaining similar values from the 45th to the 90th day of life. The authors think that the pattern of ICTP in the first week of life is under the influence of the adapting phenomena following delivery, in which catabolic processes are predominant, while in the second period ICTP modifications are related to growing processes and then to bone turnover.
N-terminal telopeptide
Type I collagen
Bone remodeling
Catabolism
Cord blood
Bone matrix
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N-terminal telopeptide
Type I collagen
Bone remodeling
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N-terminal telopeptide
Type I collagen
Procollagen peptidase
Bone remodeling
Pyridinoline
Osteolysis
Bone disease
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Diagnostic ability of type I collagen cross-linked N-telopeptide (NTx) against bone metastasis or bone invasion of breast cancer was evaluated in comparison with type I collagen cross-linked C-telopeptide (I CTP). Subjects were 30 female patients with breast cancer having bone metastasis or bone invasion. As the number of bone lesions increased, both NTx and I CTP levels increased. Levels of I CTP correlated better to the number of bone metastatic foci than those of NTx. Each biochemical marker showed higher levels in patients with bone metastasis than in those without bone lesions. Ratios of the patients with above the cut-off level of the biochemical marker were 16.7% in NTx and 56.7% in I CTP. Patients with poorly controlled bone metastasis showed twice the levels than those with well controlled lesions in I CTP, and 1.7-fold the levels in NTx. However, the average of the NTx was smaller than the cut off level even in patients with progressive bone metastasis. In conclusion, I CTP is a more useful biochemical marker than NTx in the diagnosis of bone metastasis in breast cancer.
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Article Accelerated Bone Degradation in Thyroid Carcinoma Patients during Thyroxine Treatment, Measured by Determination of the Carboxyterminal Telopeptide Region of Type I Collagen in Serum was published on January 1, 1994 in the journal Clinical Chemistry and Laboratory Medicine (CCLM) (volume 32, issue 11).
N-terminal telopeptide
Type I collagen
Procollagen peptidase
Protein precursor
Bone remodeling
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N-terminal telopeptide
Type I collagen
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N-terminal telopeptide
Type I collagen
Deoxypyridinoline
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