P714 LIVER GENE EXPRESSION OF VISFATIN, OMENTIN, CHEMERIN AND CHEMERIN RECEPTOR IN CHRONIC HEPATITIS C
Michał KuklaBrygida AdamekMarek HartlebMarzena Zalewska−ZiobBarbara Sobala‐SzczygiełL KępaMarek WalugaRafał Jakub BułdakJanusz KasperczykAndrzej WiczkowskiAna GabrielK Zwirska-Korczala
0
Citation
0
Reference
10
Related Paper
Keywords:
Chemerin
Background and aim Adipokines and hepatokines are proteins secreted by adipose tissue and the liver. To date, the levels of adipokines and hepatokines in cholelithiasis have only been evaluated in studies in adult patients. The purpose of our research was to assess the levels of circulating adipokines: chemerin, vaspin, progranulin, retinol‐binding protein 4 (RBP‐4) and hepatokine: fibroblast growth factor 21 (FGF‐21) and to compare their concentrations in paediatric patients with and without cholelithiasis. Methods The prospective study included 54 children and adolescents diagnosed with gallstones and 26 controls. Fasting serum levels of adipokines and hepatokine were determined by enzyme‐linked immunosorbent assays. Results The serum levels of chemerin, FGF‐21 and RBP‐4 were significantly higher in children and adolescents with gallstones compared to the control group. Elevated levels of triglycerides, RBP‐4, and a homeostatic model for assessing insulin resistance (HOMA‐IR) were observed in overweight or obese patients compared to patients with normal weight and cholelithiasis. Chemerin concentrations were increased in the normal‐weight children and adolescents with cholelithiasis compared to the control group. Children and adolescents with gallstones and abnormal weight had significantly higher levels of chemerin, FGF‐21 and RBP‐4 than healthy controls. Conclusion Elevated serum chemerin levels were significantly higher in non‐obese patients with cholelithiasis than in non‐obese controls, suggesting a potential role of chemerin in the development of cholelithiasis in children and adolescents.
Chemerin
Cite
Citations (10)
Chemerin is a new chemotactic protein that recently joined the adipokines family.It has been shown to play a role in adipogenesis and energy metabolism, including its role on obesity, Type 2 Diabetes Mellitus (T2DM), metabolic syndrome and cardiovascular diseases.Probiotics may play role in the prevention of obesity by various mechanisms and treatment of many diseases such as T2DM.In this study, we aimed to evaluate the effects of probiotic supplementation of chemerin adipokines on serum levels and obesity markers in obese animal models.For this purpose 3 groups of experimental animals were formed.In the obtained serum samples, the effects of probiotic supplementation on chemerin and leptin level which are indicators of obesity will be examined.Weights of all the rats in the groups were weighed each week to monitor the obesity.The weight gain in the group fed with probiotic supplementation was 10,00±27,2 g for 4 weeks and the weight gain for the group fed with high fat diet was 26,200±7,085 g (p<0.05).After 8 weeks of feding the changes of BMI values of the rats were found to be statistically significant (p<0.05).There was no significant difference between the leptin values of the groups, but the difference between the mean values of the chemerin values after 12 weeks of feeding was found to be statistically significant (p <0.05).As a result; this study showed that obese rats reduced the weight gain of probiotic supplementation without calorie restriction, positive effects on BMI and chemerin adipokine serum levels.
Chemerin
Cite
Citations (2)
Abstract Adipose tissue communicates with other central and peripheral organs by the synthesis and release of substances called adipokines. The most studied adipokine is leptin but others have been recently identified including resistin, adiponectin, chemerin, omentin and visfatin. These adipokines have a critical role in the development of obesity-related complications and inflammatory conditions. However, they are also involved in other functions in the organism including reproductive functions. Indeed, many groups have demonstrated that adipokine receptors, such as adiponectin and chemerin, but also adipokines themselves (adiponectin, chemerin, resistin, visfatin and omentin) are expressed in human peripheral reproductive tissues and that these adipokines are likely to exert direct effects on these tissues. After a brief description of these new adipokines, an overview of their actions in different human reproductive organs (hypothalamus, pituitary, ovary, testis, uterus and placenta) will be presented. Finally, comments will be made on the eventual alterations of these adipokines in reproductive disorders, with special attention to polycystic ovary syndrome, a disease characterized by dysfunction of gonadal axis and systemic nerve endocrine metabolic network with a prevalence of up to 10% in women of reproductive age.
Chemerin
Resistin
Kisspeptin
Cite
Citations (82)
Chemerin
Cite
Citations (2)
Objective: The hormones of adipose tissue, so called adipokines, possess either anti-inflammatory (apelin) or pro-inflammatory (chemerin) properties affecting local and systemic inflammation. Nonetheless, statins have potent anti-inflammatory effects in tissues and organs contributing to favorable outcomes. The aim of this study was to calculate apelin and chemerin adipokines plasma levels in patients with impaired lipid levels receiving statins exploring another potential pleotropic impact of statin therapy. Design and method: Overall, 127 patients were studied. Of them, 66 were treated with statins and 61 were not. Apelin and chemerin plasma levels were measured by the Elisa method. Results: Apelin levels were higher in patients treated with statins while chemerin levels were lower. No significant differences in demographic characteristics, arterial hypertension and diabetes mellitus were observed between the two groups (Table). Conclusions: The anti-inflammatory adipokine apelin was increased in patients receiving statins whereas the pro-inflammatory adipokine chemerin was decreased underlining an alternative anti-inflammatory effect of statin therapy.
Chemerin
Apelin
Cite
Citations (0)
Chemerin
Cite
Citations (10)
There are a large number of adipokines secreted by adipose tissue such as adiponectin,leptin,resistin etc,all these adipokines are involved in the development of the metabolic syndrome. In recent years,an adipokine named chemerin has been reported in the pathogenesis of this disease,such as insulin resistance,lipid disorders.
Chemerin
Resistin
Pathogenesis
Cite
Citations (0)
Gestational diabetes mellitus (GDM) is one of the most common medical disorders in pregnancy. Adipokines, predominantly secreted by adipose tissue, are involved in numerous metabolic processes. The exact role of adipokines in the pathogenesis of GDM is still not well known, and numerous adipokines have been analysed throughout pregnancy and proposed as biomarkers of GDM. This study aimed to evaluate serum adiponectin, chemerin, lipocalin and apelin levels in GDM and non-GDM women, to assess them as clinically useful biomarkers of the occurrence of GDM and to demonstrate the correlation between the levels of the above adipokines in the blood serum and the increased risk of the development of GDM. The role of these adipokines in the pathogenesis of GDM was also analysed. The statistically significant differences between the levels of adiponectin (7234.6 vs. 9837.5 ng/mL, p < 0.0001), chemerin (264.0 vs. 206.7 ng/mL, p < 0.0001) and lipocalin (39.5 vs. 19.4 ng/mL, p < 0.0001) were observed between pregnant women with GDM and healthy ones. The diagnostic usefulness of the tested adipokines in detecting GDM was also assessed. The research results confirm the hypothesis on the significance of adiponectin, chemerin, lipocalin and apelin in the pathophysiological mechanisms of GDM. We speculate that these adipokines could potentially be established as novel biomarkers for the prediction and early diagnosis of GDM.
Chemerin
Apelin
Cite
Citations (4)
Abstract Objective: Several adipose tissue bioactive factors (adipokines) have been linked to atherosclerosis, namely adiponectin, apelin and omentin-1 prevent atherosclerosis whereas resistin, visfatin and chemerin predispose to the development of coronary atherosclerotic plaques. The aim of this study was to calculate adipokines plasma levels in patients with and without angiographically established coronary artery disease (CAD) investigating any potential corellation between them and CAD. Design and method: Overall, 80 patients (40 with significant CAD and 40 without significant CAD) were studied. Adiponectin, apelin, omentin-1, resistin, visfatin and chemerin plasma levels were measured by the Elisa method. Results: Adiponectin, apelin and omentin-1 plasma levels were significantly lower in patients with CAD whereas visfatin, resistin and chemerin levels were significantly higher compared to those without CAD (Figure). No significant differences in demographic characteristics were observed between the two groups (Table). Conclusions: In patients with angiographically established CAD cardioprotective adipokines were lower while non-cardioprotective adipokines were higher indicating a direct relationship of these factors with the progression of atherosclerosis.
Chemerin
Resistin
Apelin
Coronary atherosclerosis
Cite
Citations (0)
Chemerin was identified as a new adipokine in 2007.Recent investigations revealed that both chemerin and chemerin receptor(chemerinR)genes were highly expressed in white adipose tissues.Chemerin was a novel adipokine involved in the regulation of adipocyte differentiation and metabolism,which was also a novel adipokine correlated with obesity and aspects of metabolic syndrome.Further research on of the function of chemerin may lead to novel approaches for the treatment of obesity and its related diseases.
Chemerin
Cite
Citations (0)