Surgery and the Progression of the Occlusive Process in Patients with Peripheral Vascular Disease
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The angiograms and clinical records of 42 patients with arteriosclerosis obliterans who underwent repeat angiography were analyzed in order to correlate the effects of surgery with progression of the occlusive process in native vessels. Occlusive disease progressed significantly faster in operated limbs (77%) than in nonoperated limbs (44%). When progression occurred, it was more likely to take the form of occlusion in operated limbs (85 %) than in nonoperated limbs (61 %). Graft closure was associated with a 93% incidence of disease progression, but even limbs with patent grafts had a more rapid progression than the nonoperated limbs (62% vs. 44%). There was a good correlation between the presence of symptoms and the angiographic progression.Keywords:
Arteriosclerosis obliterans
Arteriosclerosis
Age, arteriosclerosis indices, HDL-cholesterol, hyperlipoproteinemia, lipoproteins In 193 normal persons, 86 patients with arteriosclerosis obliterans of the lower extremities, 170 HLP patients, 87 adiposity patients and 22 chronic alcoholics were determined the arteriosclerosis indices (formula; see text) The arteriosclerosis indices increase in healthy males from the age of 30 and healthy females from the age of 45. In case of peripheral arterial occlusion HLP and adiposity the arteriosclerosis indices are elevated and give diagnostic and prognostic hints as to increased arteriosclerotic risk for these diseases.
Arteriosclerosis
Arteriosclerosis obliterans
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Objective:To explore the MR TRICKS's diagnostic value and technical advantages with arteriosclerosis obliterans of lower extremity.Methods:11 cases of arteriosclerosis obliterans of lower extremity which were proved by test of clinic and imaging in my hospital were included in retrospective analysis,all patients were proceeded with MR TRICKS to scan both lower extremities' blood vessels with TRICKS of successive scanning technique,and then to carry out blood vessel reppeared with original image by MPR and MIP.All patients were undertook Ultrasonography,two of them had DSA examination.Results:In 11 cases,one had common iliac arteriosclerosis;one had internal iliac arterial occlusion;tow cases had femoral arteriosclerosis or/of obliteration;four case had popliteal arteriosclerosis or/of obliteration;tow cases had leg arteriosclerosis;one case with restlessness multiple segment arteriosclerosis.Two cases'examination of the MR TRICKS were similar to the DSA.Conclusions:TRICKS in Magnetic resonance angiography could display its extent and ambit of artery of lower extremity's stenosis and obliteration,which provided accurate diagnosis location and therapy base for clinician.It is more optimization examination for Arteriosclerosis Obliterans of lower extremity.
Arteriosclerosis obliterans
Arteriosclerosis
Magnetic resonance angiography
Popliteal artery
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The most important degenerative lesions concomitant with diabetes mellitus are those of the vascular system. Not only do these vascular lesions give rise to clinically important diseases involving the retina of the eye, coronary arteries, kidneys, nervous system, and all elements of the peripheral vascular tree, but they remain the most common cause of death in diabetics.1Because of the association of diabetes and arteriosclerosis, the observation that the vascular lesions are of secondary causal relationship has been widely accepted. Moschowitz, however, has compared the incidence of hyperplastic arteriosclerosis in the aorta and pulmonary and coronary arteries of diabetics and nondiabetics dying of carcinoma, peptic ulcer, and essential hypertension. There was no significant difference.2Furthermore, he found that in older diabetics 36% of men and 17.5% of women had a simultaneous onset of both diabetes and arteriosclerosis or that the diabetes developed subsequent to arteriosclerotic involvement. Boas has
Arteriosclerosis
Coronary arteries
Arteriosclerotic heart disease
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Clinical data on 50 patients with arteriosclerosis obliterans (ASO) in China (Group A) and Japan (Group B) respectively were studied for better understanding of these changing trends. The results showed that the incidence of ASO peaked in Group A in the 50 to 69 age range (88%) and in Group B in the 55 to 74 age range (78%). Group A had a lower ratio of smokers and cases of diabetes mellitus than Group B but a higher ratio of hypertension and a higher total cholesterol level. Angiography showed that the prevalence of atherosclerotic lesions in the lower extremities as a whole was similar for both groups. They were different in location, extent and severity of the arteries involved between the two groups. We believe that this study has shown various differences between the two groups but that the causes are probably multifactorial.
Arteriosclerosis obliterans
Arteriosclerosis
Group A
Group B
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Arteriosclerosis obliterans
Arteriosclerosis
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Objective To evaluate the value of 64-slice spiral CT angiography in diagnosing diabetic leg arteriosclerosis obliterans(DLASO).Methods 64-slice spiral CT angiography was done in 90 patients with diabete and suspected vascular disorders of lower limb.Images were analyzed on the basis of the transverse CT source data including the maximum intensity projection(MIP),volume rendering(VR),multiplanar reconstruction(MPR) and curved planar reconstruction(CPR).Results 64-slice spiral CT angiography could exactly show the space relationship and anatomical detail of aortoiliac and lower extremity arteries.Arteriosclerostic obliterans was found in variant degree in 67 cases(67/90),of them,49(56.3%) were slight to medium arteriostenosis,18(20.7%) were obvious arteriostenosis and 7 were complete obstructed with collateral circulation.Conclusion 64-slice spiral CT angiography is of significant value in the assessment of arteriosclerosis obliterans of lower extremity arteries in the patients with diabetes.
Arteriosclerosis obliterans
Maximum intensity projection
Arteriosclerosis
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The background factors and surgical results of 546 patients with arteriosclerosis obliterans (ASO) in an early group (between January 1976 and December 1989) were compared with those of 454 patients in a later group (between January 1990 and July 1998). The later group was older than the early group and had less critical leg ischemia. In the later group, there were more patients with diabetes mellitus and renal failure. There were no significant differences between the two groups in bypass patency rates and hospital deaths. It is necessary to develop a new therapy which prevents intimal hyperplasia and arteriosclerosis.
Arteriosclerosis obliterans
Arteriosclerosis
Intimal hyperplasia
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Earlier specific cell-mediated immune reactions and their modulation by different drugs were reported against human vascular antigens in patients with vascular diseases. Presently the effect of Etofibrate (Lipo-Merz) was studied on cellular immune reactions induced by human aorta with lipid plaques and on serum lipid parameters in 46 men with acute myocardial infarction and in 48 men with arteriosclerosis obliterans compared to 40 healthy controls. Leucocyte migration test and lymphocyte-mediated cytotoxicity were repeatedly investigated in the presence of human aortic extract with or without Etofibrate (2 micrograms/50 microliters). The degree of leucocyte migration inhibition and of lymphocyte-mediated cytotoxicity proved to be similar in hypherlipaemic and in normolipaemic groups. Etofibrate could decrease cellular immune reactions both in hyperlipaemic and normolipaemic patients, but its effect was more expressive in the hyperlipaemic than normolipaemic group. Three months later a reduction of cellular immune reactions was found mainly in normolipaemic patients. Ten patients with myocardial infarction and 10 arteriosclerosis obliterans patients were treated with Etofibrate (900 mg/day) for 12 weeks. After therapy, cholesterol, triglycerides, LDL concentrations were reduced, HDL level was increased and the rate of LDL:HDL decreased. Leucocyte migration inhibition and lymphocyte-mediated cytotoxicity were also diminished. This time the cellular immune reactions of treated patients were only slightly reduced "in vitro" by Etofibrate in contrast with non treated hyper- and normolipaemic patients in whom cellular immune reactions were decreased by Etofibrate similarly to the first determinations. On the basis of our observations Etofibrate may be useful in the therapy of arteriosclerotic vascular diseases with or without hyperlipaemia, because it could decrease the cellular sensitization against aortic tissue.
Arteriosclerosis
Arteriosclerosis obliterans
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Arteriosclerosis
Arteriosclerosis obliterans
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Arteriosclerosis
Arteriosclerosis obliterans
Coronary arteriosclerosis
Cerebral arteriosclerosis
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